Publications:88
Alessandro Lagana, PhD
About Me
Alessandro is an Assistant Professor of Genetics and Genomic Sciences at the Icahn School of Medicine at Mount Sinai. His main research interests are in the fields of integrative cancer genomics, cancer network biology and precision oncology.
The aim of Alessandro's research is the development and application of computational methods for integrative analysis of multi-omics data to:
- Investigate the role of coding and non-coding alterations on cancer pathogenesis and progression;
- Understand the clinical implications of intra-tumor heterogeneity and of the tumor microenvironment;
- Inform patient risk stratification;
- Develop personalized therapy selection approaches guided by next-generation sequencing technologies.
Alessandro's current research focuses on Multiple Myeloma, a genetically complex and heterogeneous malignancy of bone marrow plasma cells affecting more than 30,000 patients each year in the United States. The causal drivers of Myeloma pathogenesis are still unclear, and treatment is administered empirically on the basis of recurrence risk rather than genetic events.
Alessandro is leading the development of a precision medicine pipeline that has been successfully applied in a clinical trial to guide treatment of relapsed Multiple Myeloma patients. The goal of precision oncology is to devise optimal treatment strategies tailored to the characteristics of the individual patient’s disease. However, the widespread heterogeneity of cancer patients and drug responses pose a significant challenge in the design of effective personalized treatments. Alessandro's research addresses this extremely important challenge and aims to transform the current paradigm of empirical clinical application. The systematic use of integrative genomics, systems biology approaches, big-data analytics and novel sequencing technologies will enable physicians to provide more precise and effective personalized treatment of cancer.
Education
M.Sc. University of Catania, Catania, Italy
Ph.D. University of Catania, Catania, Italy
Language
English
Position
ASSISTANT PROFESSOR | Oncological Sciences, ASSISTANT PROFESSOR | Genetics and Genomic Sciences
Multi-Disciplinary Training Areas
Cancer Biology [CAB], Genetics and Genomic Sciences [GGS]
Publications
Selected Publications
- Longitudinal Profiling of Tumor and Immune Compartments Uncovers Patterns of Dysregulation and Associations with Response in Multiple Myeloma. Denis J. Ohlstrom, William C. Pilcher, Marina E. Michaud, Chaitanya Acharya, Sarthak Satpathy, Edgar Gonzalez-Kozlova, Reyka G. Jayasinghe, Katherine Ferguson, Hope L. Mumme, Shivani Nanda, Yizhe Song, Sowmitri Mantrala, Dimitra Karagkouni, Jessica Schulman, Nick Pabustan, Junia Vieira Dos Santos, Daniel W. Sherbenou, Jonathan J. Keats, Alexander M. Gout, Steven Foltz, Alessandro Lagana, Taxiarchis Kourelis, Ravi Vij, Madhav V. Dhodapkar, David Avigan, Hearn Jay Cho, Linda B. Baughn, Ajay K. Nooka, Sagar Lonial, Shaji Kumar, Mehmet K. Samur, Ioannis S. Vlachos, Li Ding, Sacha Gnjatic, George Mulligan, Manoj K. Bhasin. Blood cancer discovery
- Long-term remission after cilta-cel in multiple myeloma is linked to diverse T cells and low myeloid suppression. Junia Vieira dos Santos, David T. Melnekoff, Adolfo Aleman, Tarek H. Mouhieddine, Rocio Montes de Oca, Feng Wang, Sridevi Rajeeve, Sherry Bhalla, Oliver Van Oekelen, Bhaskar Upadhyaya, Yogita Ghodke-Puranik, Violetta Leshchenko, Seunghee Kim-Schulze, Adeeb Rahman, Shaked Afik, Hadas Lewinsky, Vicki Plaks, Santiago Thibaud, Hearn Jay Cho, Joshua Richter, Cesar Rodriguez, Larysa Sanchez, Adriana Rossi, Shambavi Richard, Ajai Chari, Deepu Madduri, Sundar Jagannath, Samir Parekh, Alessandro Laganà. Blood advances
- A single-cell atlas characterizes dysregulation of the bone marrow immune microenvironment associated with outcomes in multiple myeloma. William C. Pilcher, Lijun Yao, Edgar Gonzalez-Kozlova, Yered Pita-Juarez, Dimitra Karagkouni, Chaitanya R. Acharya, Marina E. Michaud, Mark Hamilton, Shivani Nanda, Yizhe Song, Kazuhito Sato, Julia T. Wang, Sarthak Satpathy, Yuling Ma, Jessica Schulman, Darwin D’Souza, Reyka G. Jayasinghe, Denis Ohlstrom, Katherine E. Ferguson, Giulia Cheloni, Mojtaba Bakhtiari, Nick Pabustan, Kai Nie, Jennifer A. Foltz, Isabella Saldarriaga, Rania Alaaeldin, Eva Lepisto, Rachel Chen, Mark A. Fiala, Beena E. Thomas, April Cook, Junia Vieira Dos Santos, Chiang I-ling, Igor Figueiredo, Julie Fortier, Michael Slade, Stephen T. Oh, Michael P. Rettig, Emilie Anderson, Ying Li, Nicolas F. Fernandez, Geoffrey Kelly, Brian H. Lee, Travis Dawson, Adeeb H. Rahman, Zhihong Chen, Alessandro Lagana, Seunghee Kim-Schulze, Hearn J. Cho, Sacha Gnjatic. Nature Cancer
Industry Relationships
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.
Dr. Lagana has not yet completed reporting of Industry relationships.
Mount Sinai’s faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.