Publications:24
Alessia Baccarini, PhD
About Me
Dr. Alessia Baccarini is an Associate Professor in the Department of Genetics and Genomic Sciences. She trained in molecular biology and biotechnology at the University of Rome and Harvard Medical School; where she focused on the role of YAP in DNA damage and cancer. She joined Mount Sinai in 2008, and led studies that uncovered one of the first known factors to control microRNA turnover and decay. She subsequently helped lead work on the first microRNA decoy and sensor vector libraries, and developed a new high-throughput approach, called Sensor-seq, which enables genome-wide measure of microRNA activity. She used the microRNA sensor library to determine the quantitative relationship between a microRNA’s concentration and its capacity for target suppression. These studies led to the finding that microRNAs only function above a threshold concentration, and that there is widespread post-transcriptional regulation of microRNA activity. She is now investigating the functions of non-coding RNAs in cancer biology.
Language
English
Position
ASSOCIATE PROFESSOR | Immunology & Immunotherapy
Research Topics
Cancer, Gene Regulation, Molecular Biology, Oncogenes, RNA
Education
BSc, La Sapienza di Roma
PhD, La Sapienza di Roma
Awards
Paola Campese Award for Leukemia Research
Italian Scientists and Scholars Foundation (ISSNAF)
Publications
Selected Publications
- Armored macrophage-targeted CAR-T cells reset and reprogram the tumor microenvironment and control metastatic cancer growth. Jaime Mateus-Tique, Ashwitha Lakshmi, Bhavya Singh, Rhea Iyer, Alfonso R. Sánchez-Paulete, Chiara Falcomatà, Matthew Lin, Gvantsa Pantsulaia, Alexander Tepper, Trung Nguyen, Angelo Amabile, Gurkan Mollaoglu, Luisanna Pia, Divya Chhamalwan, Jessica Le Berichel, Hunter Potak, Marco Colonna, Alessia Baccarini, Joshua Brody, Miriam Merad, Brian D. Brown. Cancer Cell
- mRNA vaccine immunity is enhanced by hepatocyte detargeting and not dependent on dendritic cell expression. Adam Marks, Sophia Siu, Filippo Bianchini, Chunxi Wang, Ashwitha Lakshmi, Matthew Phelan, Andrew Zhu, Chang Moon, Judit Morla-Folch, Abraham J.P. Teunissen, Angelo Amabile, Alessia Baccarini, Miriam Merad, Joshua D. Brody, Yizhou Dong, Brian D. Brown. Nature Biotechnology
- Ovarian cancer-derived IL-4 promotes immunotherapy resistance. Gurkan Mollaoglu, Alexander Tepper, Chiara Falcomatà, Hunter T. Potak, Luisanna Pia, Angelo Amabile, Jaime Mateus-Tique, Noam Rabinovich, Matthew D. Park, Nelson M. LaMarche, Rachel Brody, Lindsay Browning, Jia Ren Lin, Dmitriy Zamarin, Peter K. Sorger, Sandro Santagata, Miriam Merad, Alessia Baccarini, Brian D. Brown. Cell
Industry Relationships
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.
Dr. Baccarini has not yet completed reporting of industry relationships or has no industry relationships to report.
Mount Sinai’s faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.