![Alexander Charney](https://www.mountsinai.org/files/fad_img_new/213/0000076810097664476791/0000072500004334845991.jpg)
Alexander Charney, MD, PhD
About Me
Alex Charney is an Associate Professor with primary appointments in the Departments of Psychiatry and Genetics & Genomic Sciences, as well as secondary appointments in the Departments of Neuroscience and Neurosurgery. He is also Director of the Charles Bronfman Institute for Personalized Medicine
As a physician-scientist specializing in the neurobiology of neuropsychiatric illness, his work is focused on translating genomic discoveries to experimental therapeutics. He received his MD and PhD under the mentorship of Pamela Sklar, MD, PhD, and Eric Schadt, PhD, two of the world's foremost experts on large-scale genomics and multiscale biology. Within his field, Alex is best known for using multiple types of genomic data to dissect the clinical features of schizophrenia and bipolar disorder, developing a novel framework for human brain research with the Living Brain Project, and advocating for the rapid translation of genomic findings to early-phase clinical trials of experimental therapeutics. His expertise is in the genetic architecture of neuropsychiatric disease and integrative approaches to analyzing multiscale datasets. He has been the lead data scientist on genetic studies of schizophrenia and bipolar disorder, including genome-wide association studies, copy number variant studies and rare sequencing variant studies. Currently, he plays a lead role in several of the largest studies in the field of psychiatric genomics. Alex has established a unique approach to human brain research as the founder and primary investigator of the Living Brain Project, a multiscale, data-driven investigation of the human brain wherein a single living population is being studied using all of the tools available for human-subject neuroscience, including the tools of molecular and cellular neurobiology that to date have been applied primarily in the post-mortem setting. In the setting of the COVID-19 pandemic, Alex utilized his training as a clinician and scientist to lead the research response at the epicenter of New York City.
Language
Position
Hospital Affiliations
- Mount Sinai Beth Israel
- Mount Sinai Morningside
- Mount Sinai Brooklyn
- Mount Sinai Queens
- The Mount Sinai Hospital
- Mount Sinai West
Research Topics
Bioinformatics, Computational Neuroscience, Genetics, Genetics of Movement disorders, Genomics, Human Genetics and Genetic Disorders, Neuro-degeneration/protection, Neurobiology, Neuroscience, Parkinson's Disease, Personalized Medicine, Pharmacogenomics, Psychiatry, Schizophrenia
Multi-Disciplinary Training Areas
Artificial Intelligence and Emerging Technologies in Medicine [AIET], Genetics and Genomic Sciences [GGS], Neuroscience [NEU]
About Me
Alex Charney is an Associate Professor with primary appointments in the Departments of Psychiatry and Genetics & Genomic Sciences, as well as secondary appointments in the Departments of Neuroscience and Neurosurgery. He is also Director of the Charles Bronfman Institute for Personalized Medicine
As a physician-scientist specializing in the neurobiology of neuropsychiatric illness, his work is focused on translating genomic discoveries to experimental therapeutics. He received his MD and PhD under the mentorship of Pamela Sklar, MD, PhD, and Eric Schadt, PhD, two of the world's foremost experts on large-scale genomics and multiscale biology. Within his field, Alex is best known for using multiple types of genomic data to dissect the clinical features of schizophrenia and bipolar disorder, developing a novel framework for human brain research with the Living Brain Project, and advocating for the rapid translation of genomic findings to early-phase clinical trials of experimental therapeutics. His expertise is in the genetic architecture of neuropsychiatric disease and integrative approaches to analyzing multiscale datasets. He has been the lead data scientist on genetic studies of schizophrenia and bipolar disorder, including genome-wide association studies, copy number variant studies and rare sequencing variant studies. Currently, he plays a lead role in several of the largest studies in the field of psychiatric genomics. Alex has established a unique approach to human brain research as the founder and primary investigator of the Living Brain Project, a multiscale, data-driven investigation of the human brain wherein a single living population is being studied using all of the tools available for human-subject neuroscience, including the tools of molecular and cellular neurobiology that to date have been applied primarily in the post-mortem setting. In the setting of the COVID-19 pandemic, Alex utilized his training as a clinician and scientist to lead the research response at the epicenter of New York City.
Language
Position
Hospital Affiliations
- Mount Sinai Beth Israel
- Mount Sinai Morningside
- Mount Sinai Brooklyn
- Mount Sinai Queens
- The Mount Sinai Hospital
- Mount Sinai West
Research Topics
Bioinformatics, Computational Neuroscience, Genetics, Genetics of Movement disorders, Genomics, Human Genetics and Genetic Disorders, Neuro-degeneration/protection, Neurobiology, Neuroscience, Parkinson's Disease, Personalized Medicine, Pharmacogenomics, Psychiatry, Schizophrenia
Multi-Disciplinary Training Areas
Artificial Intelligence and Emerging Technologies in Medicine [AIET], Genetics and Genomic Sciences [GGS], Neuroscience [NEU]
Video
Education
BA, New York University
MD, Icahn School of Medicine at Mount Sinai
Postdoc, Icahn School of Medicine at Mount Sinai
PhD, Icahn School of Medicine at Mount Sinai
Resident, Icahn School of Medicine at Mount Sinai
Awards
2020
Friedman Brain Institute Scholar
Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
2018
Chief Resident for Research
Icahn School of Medicine at Mount Sinai
2018
Travel Award
Pathways to Drugs Meeting
2018
Young Investigator Award
NARSAD
2017
Fellow
Leon Levy Foundation
2016
Outstanding Resident Award Program Awardee
National Institute of Mental Health
2016
Friedman Brain Institute Scholars Awardee
Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
Publications
Selected Publications
- Evaluation of imputation performance of multiple reference panels in a Pakistani population. Jiayi Xu, Dongjing Liu, Arsalan Hassan, Giulio Genovese, Alanna C. Cote, Brian Fennessy, Esther Cheng, Alexander W. Charney, James A. Knowles, Muhammad Ayub, Roseann E. Peterson, Tim B. Bigdeli, Laura M. Huckins. Human Genetics and Genomics Advances
- Sex Differences in Long COVID. Dimpy P. Shah, Tanayott Thaweethai, Elizabeth W. Karlson, Hector Bonilla, Benjamin D. Horne, Janet M. Mullington, Juan P. Wisnivesky, Mady Hornig, Daniel J. Shinnick, Jonathan D. Klein, Nathaniel B. Erdmann, Shari B. Brosnahan, Joyce K. Lee-Iannotti, Torri D. Metz, Christine Maughan, Ighovwerha Ofotokun, Harrison T. Reeder, Lauren E. Stiles, Aasma Shaukat, Rachel Hess, Hassan Ashktorab, Logan Bartram, Ingrid V. Bassett, Jacqueline H. Becker, Hassan Brim, Alexander W. Charney, Tananshi Chopra, Rebecca G. Clifton, Steven G. Deeks, Kristine M. Erlandson, Daniel S. Fierer, Valerie J. Flaherman, Vivian Fonseca, Jennifer C. Gander, Sally L. Hodder, Vanessa L. Jacoby, Pavitra Kotini-Shah, Jerry A. Krishnan, Andre Kumar, Bruce D. Levy, David Lieberman, Jenny J. Lin, Jeffrey N. Martin, Grace A. McComsey, Talal Moukabary, Megumi J. Okumura, Michael J. Peluso, Clifford J. Rosen, George Saade, Pankil K. Shah. JAMA network open
- Extracting social support and social isolation information from clinical psychiatry notes: comparing a rule-based natural language processing system and a large language model. Braja Gopal Patra, Lauren A. Lepow, Praneet Kasi Reddy Jagadeesh Kumar, Veer Vekaria, Mohit Manoj Sharma, Prakash Adekkanattu, Brian Fennessy, Gavin Hynes, Isotta Landi, Jorge A. Sanchez-Ruiz, Euijung Ryu, Joanna M. Biernacka, Girish N. Nadkarni, Ardesheer Talati, Myrna Weissman, Mark Olfson, J. John Mann, Yiye Zhang, Alexander W. Charney, Jyotishman Pathak. Journal of the American Medical Informatics Association : JAMIA