Alice O Silva(kamphorst) | Mount Sinai

About Me

Alice O. Kamphorst, PhD is an Assistant Professor of Oncological Sciences at the Precision Immunology Institute. She is also a member of the Cancer Immunology Research Program at the Tisch Cancer Institute.

The Kamphorst lab focuses on T cell differentiation with a specific interest on situations of chronic antigen stimulation, such as in cancer. The research program aims to determine how inflammation, costimulation and other factors in the microenvironment influence CD8 T cell differentiation, dysfunction and rescue by immunotherapy. We study the interplay of different signaling pathways with the PD-1 (programmed cell death-1) pathway. To address those questions the lab uses mouse models of chronic viral infection and tumor, as well as analysis of samples from cancer patients.

https://kamphorstlab.org/

Language

English

Position

ASSISTANT PROFESSOR | Immunology & Immunotherapy, ASSISTANT PROFESSOR | Oncological Sciences

Research Topics

Anti-Tumor Therapy, Immunology, Infectious Disease, Inflammation, Liver, Lymphocytes, T Cells, Translational Research, Viruses and Virology

Multi-Disciplinary Training Areas

Cancer Biology [CAB], Immunology [IMM]

Education

PhD, Rockefeller University

Postdoc, Emory University

Research

The Kamphorst lab focuses on T cell differentiation with a specific interest on situations of chronic antigen stimulation, such as in cancer. The research program aims to determine how inflammation, costimulation and other factors in the microenvironment influence CD8 T cell differentiation, dysfunction and rescue by immunotherapy. We study the interplay of different signaling pathways with the PD-1 (programmed cell death-1) pathway. To address those questions the lab uses mouse models of chronic viral infection and tumor, as well as analysis of samples from cancer patients. The lab has a deep interest on how adaptive immune responses are modulated and on interventional strategies that can be used to improve human health. Understanding the factors that govern T cell differentiation and function will enable the identification of targetable molecules and pathways to improve the efficacy of immunotherapy.