Amir Horowitz, PhD
Central to my studies is how immunogenetic variation of HLA, KIR and CD94:NKG2A genes governs the education of human NK cells and regulates their ability to function within dynamic environments. A central goal of my lab’s research is to investigate the effects of genetic variation on the effector and immunoregulatory roles of NK cells in patients with cancer receiving immunotherapies. In this regard, I am uniquely positioned to undertake these studies. I first obtained expertise in immunology and infectious diseases with Moriya Tsuji, Martin Markowitz and David Ho (Rockefeller University) and with Eleanor Riley (London School of Hygiene and Tropical Medicine). I then pursued post-doctoral expertise in evolutionary and population immunogenetics, structural biology, and epidemiology with Peter Parham (Stanford University). I have cultivated long-standing collaborations with leading scientists in the field of NK cell immunology and HLA genetics and currently have studies focused across settings of hematologic and solid tumor malignancies.
Anti-Tumor Therapy, Autoimmunity, Bioinformatics, Cancer Genetics, Cellular Immunity, Epidemiology, Genetics, HIV/AIDS, Immunology, Infectious Disease, Lymphocytes, Personalized Medicine, Structural Biology, T Cells, Tolerance, Translational Research, Transplantation, Tumorigenesis, Vaccine Development
Multi-Disciplinary Training Areas
Cancer Biology [CAB]