Publications:172
Aneel K Aggarwal, PhD
About Me
Dr. Aggarwal is an internationally recognized structural biologist, who earned his PhD in biophysics at Kings College, University of London, in 1984. From 1985 to 1987, Dr. Aggarwal participated in a NATO research fellowship and was also a postdoctoral fellow in the Department of Biochemistry and Molecular Biology at Harvard University. He then became an Assistant Professor at Columbia University before joining the Mount Sinai Medical School. He is currently a Professor in the Department of Structural & Chemical Biology and holds an Endowed Chair as the Mount Sinai Professor in Structural Biology.
Dr. Aggarwal is a member of the Cancer Mechanisms Program at The Tisch Cancer Institute.
Language
English
Position
PROFESSOR | Pharmacological Sciences, PROFESSOR | Oncological Sciences
Research Topics
DNA Repair, DNA Replication, Structural Biology, Transcription Factors, Translation
Multi-Disciplinary Training Areas
Cancer Biology [CAB], Disease Mechanisms and Therapeutics (DMT), Genetics and Genomic Sciences [GGS]
Education
PhD, Kings College, University of London
, Harvard University
Awards
2012
Dean’s Award for Excellence in Basic Science Research
2010
Faculty Council Award for Academic Excellence
2007
Mount Sinai Professor in Structural Biology (Endowed Chair)
1995
The Doctor Harold and Golden Lamport Award for Excellence in Basic Science Research
1990
Irma T. Hirschl Career Scientist Award
1990
Basil O'Connor Starter Scholar Research Award
1985
The North Atlantic Treaty Organization (NATO) Research Fellowship
1985
EMBO Long-term Fellowship (Declined)
1981
Science and Engineering Research Council (SERC) of Great Britain Studentship
Research
We use a variety of structural tools to uncover how enzymes, and transcription and translation regulators interact with nucleic acids to affect cellular development and disease outcome. We study how such proteins locate, bind, and move on their DNA or RNA sites, and, then use that knowledge to create enzymes with new specificities and obtain a molecular understanding for how genes are regulated. We are also interested in learning how cells cope with the effects of DNA damage. In particular, we investigate how a set of specialized DNA polymerases can bypass DNA damage during replication and how mutations in them can lead to cancer.
Publications
Selected Publications
- Mechanism of DNA degradation by CBASS Cap5 endonuclease immune effector. Olga Rechkoblit, Daniela Sciaky, Mi Ni, Yangmei Li, Jithesh Kottur, Gang Fang, Aneel K. Aggarwal. Nature Communications
- An eRNA transcription checkpoint for diverse signal-dependent enhancer activation programs. Lishuan Wang, Wei Yuan, Amir Gamliel, Wubin Ma, Seowon Lee, Yuliang Tan, Zeyu Chen, Havilah Taylor, Kenneth Ohgi, Soohwan Oh, Aneel K. Aggarwal, Michael G. Rosenfeld. Nature Genetics
- Burkholderia cenocepacia epigenetic regulator M.BceJIV simultaneously engages two DNA recognition sequences for methylation. Richard Quintana-Feliciano, Jithesh Kottur, Mi Ni, Rikhia Ghosh, Leslie Salas-Estrada, Goran Ahlsen, Olga Rechkoblit, Lawrence Shapiro, Marta Filizola, Gang Fang, Aneel K. Aggarwal. Nature Communications