Brandon L Dale
About Me
Brandon Dale, PhD is a current MD/PhD student in the Pharmacology, Therapuetics and Discovery multidisciplinary training area at the Graduate School of Biomedical Sciences at Icahn School of Medicine at Mount Sinai. Brandon Dale graduated from Brown University in 2017 with a BA degree in Chemistry and Anthropology. His hometown is Lafayette, Louisiana, and he enjoys the outdoors, fly fishing, conservation, cooking and building community.
Abstracts, Articles and Posters
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Wen, H., Xue, Z., Qin, L., Xuan, H., Luo, K., Huang, M., Xie, L., Su, Y., Xu, L., Harsh, J., Dale, B., Shi, X., Chen, X., Kaniskan, H. Ü., and Jin, J. (2024). A potent and selective ENL degrader suppresses oncogenic gene expression and leukemia progression. Science Advances, In Press.
Velez, J., Dale, B., Park, K. S., Kaniskan, H. Ü., Yu, X., & Jin, J. (2024). Discovery of a novel, highly potent EZH2 PROTAC degrader for targeting non-canonical oncogenic functions of EZH2. European Journal of Medicinal Chemistry, 116154.
Park, K. S., Qin, L., Kabir, M., Luo, K., Dale, B., Zhong, Y., ... & Jin, J. (2023). Targeted degradation of PRC1 components, BMI1 and RING1B, via a novel protein complex degrader strategy. Advanced Science, 10(10), 2205573.
Powell, S. K., Serafini, R. A., Frere, J. J., De Pins, A., Saali, A., Sultana, S. A., Ali, M., Dale, B., Datta, D., Aaronson, C.,.. & Gluhoski, V. (2023). Provision of Cognitive Behavior Therapy for Depression and Anxiety Disorders by Medical Student Trainees. Academic Psychiatry, 1-8.
Balmuth, E. A., & Scammell, T. E. (2023). Harriet Tubman’s Hypersomnia: Insights from Historical and Medical Perspectives. Journal of general internal medicine, 1-7. Acknowledgement Dale, B.
Dale, B., Anderson, C., Park, K. S., Kaniskan, H. Ü., Yu, X., & Jin, J. (2022). Targeting triple negative breast cancer with a VHL recruiting EZH2 protein degrader. Cancer Research (AACR), 82(12_Supplement), 2922-2922.
Dale, B., Anderson, C., Park, K. S., Kaniskan, H. U., Ma, A., Shen, Y., ... & Jin, J. (2022). Targeting triple-negative breast cancer by a novel proteolysis targeting chimera degrader of enhancer of zeste homolog 2. ACS Pharmacology & Translational Science, 5(7), 491-507.
Yu, X., Xu, J., Shen, Y., Cahuzac, K. M., Park, K. S., Dale, B., ... & Jin, J. (2022). Discovery of potent, selective, and in vivo efficacious AKT kinase protein degraders via structure–activity relationship studies. Journal of Medicinal Chemistry, 65(4), 3644-3666.
Hoshing, R., Leeber III, B. W., Kuhn, H., Caianiello, D., Dale, B., Saladino, M., ... & Basu, A. (2022). Cover Feature: The Chirality of Aggregated Yariv Reagents Correlates with Their AGP‐Binding Ability (ChemBioChem 6/2022). ChemBioChem, 23(6), e202100613.
Powell, S. K., Saali, A., Frere, J., Magill, E., Krystal, H., Serafini, R. A., Sultana, S. Dale, B., Muhammed, A., Kumar, V., Datta, D., ... & Katz, C. L. (2022). Design of and outcomes in a student-run free mental health clinic serving the uninsured in East Harlem. BMC psychiatry, 22(1), 1-13.
Dale B, Cheng M, Park K, Xiong Y, Jin J. Advancing Targeted Protein Degradation for Cancer Therapy. Nature Reviews Cancer.Oct;21(10):638-654. doi: 10.1038/s41568-021-00365-x. PubMed PMID: 34131295; PubMed Central PMCID: PMC8463487.
Ma A, Stratikopoulos E, Park KS, Wei J, Martin TC, Yang X, Schwarz M, Leshchenko V, Rialdi A, Dale B, Lagana A, Guccione E, Parekh S, Parsons R, Jin J. Discovery of a first-in-class EZH2 selective degrader. Nat Chem Biol. 2020 Feb;16(2):214-222. doi: 10.1038/s41589-019-0421-4. Epub 2019 Dec 9. PubMed PMID: 31819273; PubMed Central PMCID: PMC6982609.
Dettweiler M, Lyles JT, Nelson K, Dale B, Reddinger RM, Zurawski DV, Quave CL. American Civil War plant medicines inhibit growth, biofilm formation, and quorum sensing by multidrug-resistant bacteria. Sci Rep. 2019 May 22;9(1):7692. doi: 10.1038/s41598-019-44242-y. PubMed PMID: 31118466; PubMed Central PMCID: PMC6531439.
Lavoie S, Sweeney-Jones AM, Mojib N, Dale B, Gagaring K, McNamara CW, Quave CL, Soapi K, Kubanek J. Antibacterial Oligomeric Polyphenols from the Green Alga Cladophora socialis. J Org Chem. 2019 May 3;84(9):5035-5045. doi: 10.1021/acs.joc.8b03218. Epub 2019 Apr 3. PubMed PMID: 30908914; PubMed Central PMCID: PMC6503470.
Richwagen N, Lyles JT, Dale BLF, Quave CL. Antibacterial Activity of Kalanchoe mortagei and K. fedtschenkoi Against ESKAPE Pathogens. Front Pharmacol. 2019;10:67. doi: 10.3389/fphar.2019.00067. eCollection 2019. PubMed PMID: 30792655; PubMed Central PMCID: PMC6374630.
Gurnee E, Lehman K, Nelson K, Dale BL, Swerlick R, Quave C. 950 Severity of pediatric atopic dermatitis correlates to hemolytic potential of S. aureus isolates from atopic lesions. Journal of Investigative Dermatology. 2018 May; 138(5):S161.
B. Dale, B. Leeber, A. Basu. Elucidating the Binding Mechanism of Arabinogalactan and Yariv Phenylglycosides through Radial Diffusion Assays and Circular Dichroism Spectroscopy. Brown University Chemistry Honors Poster Presentation. May 2017.
B. Leeber, D. Caianiello, H. Kuhn, S. Weingarten, B. Dale, R. Lusi, A. Basu. Investigating the Self-Assembly of Yariv reagents using circular dichroism spectroscopy. American Chemical Society. August, 2016.
Language
Position
Research Topics
Breast Cancer, Cancer, Cancer Genetics, Pharmacology, Protein Degradation, Protein Structure/Function
Multi-Disciplinary Training Areas
Disease Mechanisms and Therapeutics (DMT)
Download the CV
About Me
Brandon Dale, PhD is a current MD/PhD student in the Pharmacology, Therapuetics and Discovery multidisciplinary training area at the Graduate School of Biomedical Sciences at Icahn School of Medicine at Mount Sinai. Brandon Dale graduated from Brown University in 2017 with a BA degree in Chemistry and Anthropology. His hometown is Lafayette, Louisiana, and he enjoys the outdoors, fly fishing, conservation, cooking and building community.
Abstracts, Articles and Posters
_________________________________________________________________________________________________________________
Wen, H., Xue, Z., Qin, L., Xuan, H., Luo, K., Huang, M., Xie, L., Su, Y., Xu, L., Harsh, J., Dale, B., Shi, X., Chen, X., Kaniskan, H. Ü., and Jin, J. (2024). A potent and selective ENL degrader suppresses oncogenic gene expression and leukemia progression. Science Advances, In Press.
Velez, J., Dale, B., Park, K. S., Kaniskan, H. Ü., Yu, X., & Jin, J. (2024). Discovery of a novel, highly potent EZH2 PROTAC degrader for targeting non-canonical oncogenic functions of EZH2. European Journal of Medicinal Chemistry, 116154.
Park, K. S., Qin, L., Kabir, M., Luo, K., Dale, B., Zhong, Y., ... & Jin, J. (2023). Targeted degradation of PRC1 components, BMI1 and RING1B, via a novel protein complex degrader strategy. Advanced Science, 10(10), 2205573.
Powell, S. K., Serafini, R. A., Frere, J. J., De Pins, A., Saali, A., Sultana, S. A., Ali, M., Dale, B., Datta, D., Aaronson, C.,.. & Gluhoski, V. (2023). Provision of Cognitive Behavior Therapy for Depression and Anxiety Disorders by Medical Student Trainees. Academic Psychiatry, 1-8.
Balmuth, E. A., & Scammell, T. E. (2023). Harriet Tubman’s Hypersomnia: Insights from Historical and Medical Perspectives. Journal of general internal medicine, 1-7. Acknowledgement Dale, B.
Dale, B., Anderson, C., Park, K. S., Kaniskan, H. Ü., Yu, X., & Jin, J. (2022). Targeting triple negative breast cancer with a VHL recruiting EZH2 protein degrader. Cancer Research (AACR), 82(12_Supplement), 2922-2922.
Dale, B., Anderson, C., Park, K. S., Kaniskan, H. U., Ma, A., Shen, Y., ... & Jin, J. (2022). Targeting triple-negative breast cancer by a novel proteolysis targeting chimera degrader of enhancer of zeste homolog 2. ACS Pharmacology & Translational Science, 5(7), 491-507.
Yu, X., Xu, J., Shen, Y., Cahuzac, K. M., Park, K. S., Dale, B., ... & Jin, J. (2022). Discovery of potent, selective, and in vivo efficacious AKT kinase protein degraders via structure–activity relationship studies. Journal of Medicinal Chemistry, 65(4), 3644-3666.
Hoshing, R., Leeber III, B. W., Kuhn, H., Caianiello, D., Dale, B., Saladino, M., ... & Basu, A. (2022). Cover Feature: The Chirality of Aggregated Yariv Reagents Correlates with Their AGP‐Binding Ability (ChemBioChem 6/2022). ChemBioChem, 23(6), e202100613.
Powell, S. K., Saali, A., Frere, J., Magill, E., Krystal, H., Serafini, R. A., Sultana, S. Dale, B., Muhammed, A., Kumar, V., Datta, D., ... & Katz, C. L. (2022). Design of and outcomes in a student-run free mental health clinic serving the uninsured in East Harlem. BMC psychiatry, 22(1), 1-13.
Dale B, Cheng M, Park K, Xiong Y, Jin J. Advancing Targeted Protein Degradation for Cancer Therapy. Nature Reviews Cancer.Oct;21(10):638-654. doi: 10.1038/s41568-021-00365-x. PubMed PMID: 34131295; PubMed Central PMCID: PMC8463487.
Ma A, Stratikopoulos E, Park KS, Wei J, Martin TC, Yang X, Schwarz M, Leshchenko V, Rialdi A, Dale B, Lagana A, Guccione E, Parekh S, Parsons R, Jin J. Discovery of a first-in-class EZH2 selective degrader. Nat Chem Biol. 2020 Feb;16(2):214-222. doi: 10.1038/s41589-019-0421-4. Epub 2019 Dec 9. PubMed PMID: 31819273; PubMed Central PMCID: PMC6982609.
Dettweiler M, Lyles JT, Nelson K, Dale B, Reddinger RM, Zurawski DV, Quave CL. American Civil War plant medicines inhibit growth, biofilm formation, and quorum sensing by multidrug-resistant bacteria. Sci Rep. 2019 May 22;9(1):7692. doi: 10.1038/s41598-019-44242-y. PubMed PMID: 31118466; PubMed Central PMCID: PMC6531439.
Lavoie S, Sweeney-Jones AM, Mojib N, Dale B, Gagaring K, McNamara CW, Quave CL, Soapi K, Kubanek J. Antibacterial Oligomeric Polyphenols from the Green Alga Cladophora socialis. J Org Chem. 2019 May 3;84(9):5035-5045. doi: 10.1021/acs.joc.8b03218. Epub 2019 Apr 3. PubMed PMID: 30908914; PubMed Central PMCID: PMC6503470.
Richwagen N, Lyles JT, Dale BLF, Quave CL. Antibacterial Activity of Kalanchoe mortagei and K. fedtschenkoi Against ESKAPE Pathogens. Front Pharmacol. 2019;10:67. doi: 10.3389/fphar.2019.00067. eCollection 2019. PubMed PMID: 30792655; PubMed Central PMCID: PMC6374630.
Gurnee E, Lehman K, Nelson K, Dale BL, Swerlick R, Quave C. 950 Severity of pediatric atopic dermatitis correlates to hemolytic potential of S. aureus isolates from atopic lesions. Journal of Investigative Dermatology. 2018 May; 138(5):S161.
B. Dale, B. Leeber, A. Basu. Elucidating the Binding Mechanism of Arabinogalactan and Yariv Phenylglycosides through Radial Diffusion Assays and Circular Dichroism Spectroscopy. Brown University Chemistry Honors Poster Presentation. May 2017.
B. Leeber, D. Caianiello, H. Kuhn, S. Weingarten, B. Dale, R. Lusi, A. Basu. Investigating the Self-Assembly of Yariv reagents using circular dichroism spectroscopy. American Chemical Society. August, 2016.
Language
Position
Research Topics
Breast Cancer, Cancer, Cancer Genetics, Pharmacology, Protein Degradation, Protein Structure/Function
Multi-Disciplinary Training Areas
Disease Mechanisms and Therapeutics (DMT)
Download the CV