Publications:376
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Bruce D Gelb, MD
Pediatrics, Pediatric Cardiology
About Me
Dr. Bruce D. Gelb is the Gogel Family Chair and Director of The Mindich Child Health and Development Institute, Dean for Child Health Research at the Icahn School of Medicine at Mount Sinai, Director of the Center for Molecular Cardiology, and Professor of Pediatrics and Genetics and Genomic Sciences. He is board certified in Pediatric Cardiology by the American Board of Pediatrics.
In his quest to discover what causes congenital heart disease, Dr. Gelb has developed an extensive program in genomics and gene investigation, focusing on traits associated with heart malformations.
An expert in Noonan syndrome, Dr. Gelb has studied the genetic origins of this disease to understand its pathogenesis. Noonan and related syndromes result from mutations in several genes that encode proteins that cells use to signal from the outer membrane to the nucleus. Dr. Gelb and colleagues examine whether stem cells generated from cultured skin cells malfunction, leading to developmental disorders, and whether it is possible to coax cellular development to function normally.
At The Mindich Child Health and Development Institute, Dr. Gelb has created a collaborative multidisciplinary research environment to advance translational research into prevalent diseases of childhood. The emphasis is on the application of genetics and genomics toward elucidating the causes of illness affecting infants, children, and adolescents. To maximize resources and the impact of investigation, four centers of research areas were initially identified: Allergy and Asthma, Cardiovascular Defects, Neurodevelopmental Disorders, and Obesity and Diabetes; more recently, the MCHDI has expanded its focus to include broader topics in children’s health.
Dr. Gelb is a distinguished recipient of the E. Mead Johnson Award from the Society for Pediatric Research and the Norman J. Siegel New Member Outstanding Science Award from the American Pediatric Society. He was elected to the National Academy of Medicine and the American Society of Clinical Investigation. In addition to his research, Dr. Gelb directs the Cardiovascular Genetics Program at Mount Sinai. He is the current President of the International Pediatric Research Foundation and a council member of the American Pediatric Society. After earning a medical degree from the University of Rochester Medical School in Rochester, New York, Dr. Gelb completed a pediatric residency and a pediatric cardiology fellowship at Babies Hospital of Columbia-Presbyterian Medical Center and Texas Children's Hospital at the Baylor College of Medicine, respectively. He joined the faculty at Mount Sinai in 1991.
Areas of Expertise
Cardiovascular Genetics, Heart Transplantation
Language
English
Position
DIRECTOR MINDICH CHILD HEALTH AND DEVELOPMENT INSTITUTE, PROFESSOR | Pediatrics, Cardiology, PROFESSOR | Genetics and Genomic Sciences
Hospital Affiliations
- Mount Sinai Queens
- The Mount Sinai Hospital
Research Topics
Cardiovascular, Gene Discovery, Human Genetics and Genetic Disorders, Pediatrics, Signal Transduction, Stem Cells, Transgenic Mice
Multi-Disciplinary Training Areas
Development Regeneration and Stem Cells [DRS], Genetics and Genomic Sciences [GGS]
Clinical Focus
Video
Education
MD, University of Rochester School of Medicine/Dentistry
Residency, Pediatrics
Columbia Presbyterian Medical Center
Fellowship, Pediatric Cardiology
Texas Children's Hospital
Certifications
American Board of Pediatrics
Awards
2016
Best Doctors
New York Magazine
2015
Best Doctors
New York Magazine
2010
Best Doctors
New York Magazine
Research
Specific Clinical/Research Interests:
Genetics of congenital heart defects; Noonan syndrome and related disorders; Gain-of-function RAS signaling
Genetic Counselor: Meghan Mac Neal
Postdoctoral Fellows: Se-Yeon Lee, Kathryn Manheimer
Predoctoral Students: Felix Richter, Nelson Rodriguez
Research Personnel: Jian Zhang, Simon Ng, Jared Gatto, Tara Keshavarz, Yahaira Mendez
Summary of Research Studies:
The Gelb research group is focused on disease gene discovery using genomic techniques and characterization of the biological roles of such genes in disease pathogenesis. The focus of the laboratory currently is on those traits that are associated with heart malformations. In the past, we have identified disease genes for Char and Noonan syndromes. The former is TFAP2B, which encodes a transcription factor of the AP-2 family, and the latter include PTPN11, KRAS, SOS1, SOS2, RAF1 and SHOC2. We are studying the roles of these disease genes in normal developmental and homeostatic processes as well as in disease pathogenesis. We are actively studying additional human genetic traits, both simple and complex, to identify additional disease genes with a particular focus on traits with cardiovascular abnormalities. This is being done with next generation sequencing approaches, both whole exome and genome sequencing. Ongoing biologic studies focus on disease modeling using induced pluripotent stem cells, including creating mutations or correcting them with CRISPR technology. We are also studying disease genes and performing drug discovery in Drosophila melanogaster.
Insurance Information
Accepted insurance may vary by the doctor’s office location. Please contact the office directly to obtain the most up-to-date insurance information.
- 1199 SEIU
- AETNA - Commercial
- AETNA - Medicare
- Affinity Medicaid-Medicare-Essential Exchange
- Amidacare Medicaid
- CIGNA Healthcare
- Centivo
- EmblemHealth - GHI-PPO
- EmblemHealth - HIP
- EmblemHealth - HIP-Medicaid
- EmblemHealth - HIP-Medicare
- Empire Blue Cross Blue Shield - Commercial/Exchange
- Empire Blue Cross Blue Shield - HealthPlus Medicaid
- Fidelis Health Care
- HealthFirst Medicaid
- HealthFirst Medicare
- Horizon NJ
- Magnacare-Health Care
- Medicare - NJ
- Medicare - NY
- Metroplus
- Multiplan PHCS
- NJ Medicaid
- NY Medicaid
- Oscar
- Oxford - Freedom and Liberty
- United Health Care - Commercial
- United Health Care - Empire Plan
- United Health Care - Top Tier
- WellCare Health Plan
Physicians who provide services at hospitals and facilities in the Mount Sinai Health System might not participate in the same health plans as those Mount Sinai hospitals and facilities (even if the physicians are employed or contracted by those hospitals or facilities).
Information regarding insurance participation and billing by this physician may be found on this page, and can also be obtained by contacting this provider directly. Because physicians insurance participation can change, the insurance information on this page may not always be up-to-date. Please contact this physician directly to obtain the most up-to-date insurance information.
Insurance and health plan networks that the various Mount Sinai Health System hospitals and facilities participate in can be found on the Mount Sinai Health System website.
Publications
Selected Publications
- Genome sequencing is critical for forecasting outcomes following congenital cardiac surgery. W. Scott Watkins, Edgar J. Hernandez, Thomas A. Miller, Nathan R. Blue, Raquel Mae Zimmerman, Eric R. Griffiths, Erwin Frise, Daniel Bernstein, Marko T. Boskovski, Martina Brueckner, Wendy K. Chung, J. William Gaynor, Bruce D. Gelb, Elizabeth Goldmuntz, Peter J. Gruber, Jane W. Newburger, Amy E. Roberts, Sarah U. Morton, John E. Mayer, Christine E. Seidman, Jonathan G. Seidman, Yufeng Shen, Michael Wagner, H. Joseph Yost, Mark Yandell, Martin Tristani-Firouzi. Nature Communications
- Genomic rare variant mechanisms for congenital cardiac laterality defect: A digenic model approach. Archana Rai, Jonathan Klonowski, Bo Yuan, Karen J. Coveler, Zain Dardas, Iman Egab, Jiaoyang Xu, Philip J. Lupo, A. J. Agopian, Dennis Kostka, Cecilia W. Lo, S. Stephen Yi, Bruce D. Gelb, Christine E. Seidman, Eric Boerwinkle, Jennifer E. Posey, Richard A. Gibbs, James R. Lupski, Shaine A. Morris, Zeynep Coban-Akdemir. American Journal of Human Genetics
- Deficiency of the Fanconi anemia core complex protein FAAP100 results in severe Fanconi anemia. Benjamin A. Harrison, Emma Mizrahi-Powell, John Pappas, Kristen Thomas, Subrahmanya Vasishta, Shripad Hebbar, Anju Shukla, Shalini S. Nayak, Tina K. Truong, Amy Woroch, Yara Kharbutli, Bruce D. Gelb, Cassie S. Mintz, Gilad D. Evrony, Agata Smogorzewska. Journal of Clinical Investigation
Industry Relationships
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.
Below are financial relationships with industry reported by Dr. Gelb during 2024 and/or 2025. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
Board Service
- American Society of Human Genetics
Consulting or Other Professional Services Examples include, but are not limited to, committee participation, data safety monitoring board (DSMB) membership
- Pessin Katz Law, PA
- Garson Jakub & Morris, LLP
- Wilson, elser, Moskowitz, Edelman & Dicker, LLP
- Biomarin Pharmaceutical
- WCG Clinical
- Think Bioscience
- Rendigs, Fry, Kiely & Dennis, LLP
Equity (Stock or stock options valued at greater than 5% ownership of a publicly traded company or equity of any value in a privately held company)
- Think Bioscience
Mount Sinai’s faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.