Publications:48
Cameron S Mcalpine, PhD
About Me
Dr. Cameron McAlpine is an Associate Professor in the Department of Medicine, Cardiology, and the Nash Family Department of Neuroscience. He is a Principal Investigator in the Cardiovascular Research Institute and is a faculty member of the Friedman Brain Institute, the Lipschultz Precision Immunology Institute, and the Brain-Body Research Institute.
Dr. McAlpine completed his PhD at McMaster University in Canada and his postdoctoral training at the Massachusetts General Hospital and Harvard Medical School. The overarching theme of the McAlpine lab is to investigate brain-body communication circuits in chronic inflammatory disorders. We have specific focuses on (1) the neural output and interoceptive mechanisms associating sleep and inflammation in cardiovascular disease, and (2) the involvement of hematopoietic growth factors in glial-peripheral immune crosstalk during neurodegenerative diseases and neurodevelopmental disorders. We use mouse models and human trials to study how lifestyle factors, including sleep and exercise, modulate these interactions. The McAlpine lab incorporates innovative tools and approaches at the interface of immunology, cardiology, and neuroscience to study the neuro-immune and brain-body interactions that maintain heart and brain health.
The McAlpine lab website can be found here: https://labs.icahn.mssm.edu/mcalpinelab/
Language
English
Position
ASSOCIATE PROFESSOR | Medicine, Cardiology, ASSOCIATE PROFESSOR | Neuroscience
Research Topics
Alzheimer's Disease, Atherosclerosis, Brain, Cardiovascular, Hematopoiesis, Immunology, Inflammation, Macrophage, Sleep Medicine
Multi-Disciplinary Training Areas
Immunology [IMM], Neuroscience [NEU]
Education
BSc, Acadia University
PhD, McMaster University
Postdoctoral Fellowship, Massachusetts General Hospital and Harvard Medical School
Publications
Selected Publications
- Tet2 and Jak2 clonal hematopoiesis do not modify murine tauopathy. Lena Gaebel, Teresa Gerhardt, Annie Khamhoung, Pacific Huynh, Merlin Heiser, Niki F. Brisnovali, Walter Jacob, Abi G. Yates, Aaron Douglas, Trevor Fidler, Leigh Goedeke, Cameron S. McAlpine. Journal of Alzheimer's Disease
- Mutation-dependent responses to sleep and exercise in clonal haematopoiesis. Teresa Gerhardt, Walter Jacob, Lena Gaebel, Merlin Heiser, Christopher Wolfram, Pacific Huynh, Tetsushi Nakao, Bernardo Gindri Dos Santos, Pamela Toh, Aaron Douglas, Niki F. Brisnovali, Emir Radkevich, Md Mesbah Uddin, Abi G. Yates, Annie Khamhoung, Nader Yatim, Matteo Gianeselli, Máté G. Kiss, Sukanya Goswami, Daniella Nelson, Rachel Chen, Darwin D’Souza, Zhihong Chen, Seunghee Kim-Schulze, Trevor Fidler, Daniel Ezzat, Shaan Khurshid, Alexander G. Bick, Pradeep Natarajan, Patrick T. Ellinor, Abha K. Rajbhandari, Miriam Merad, Filip K. Swirski, Oren Cohen, Leigh Goedeke, Michael C. Honigberg, Cameron S. McAlpine. Nature
- A controlled-release mitochondrial protonophore attenuates early- and late-stage atheroprogression in mice. Bernardo Gindri Dos Santos, Niki F. Brisnovali, Connor Haney, Myles Coven, Homa Linda Sebzevari, Lena Gaebel, Xinbo Zhang, Jonathan Sun, Alberto Canfrán-Duque, Noemi Rotllan, Ali Nasiri, Mario Kahn, Cameron S. Mcalpine, Gerald I. Shulman, Leigh Goedeke. Science Translational Medicine
Industry Relationships
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.
Dr. McAlpine has not yet completed reporting of industry relationships or has no industry relationships to report.
Mount Sinai’s faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.