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Profile image of Catarina E Hioe

    Catarina E Hioe, PhD

    Education

    BS, University of Wisconsin-Madison

    PhD, University of Wisconsin-Madison

    Fellowship, University of North Carolina- Chapel Hill

    Awards

    2012

    Research Career Scientist

    US Department of Veterans Affairs

    1992

    Postdoctoral Fellowship

    American Cancer Society

    Research

    My laboratory has established a research program that focuses on HIV immunology.  The program is supported by research funds from NIH, VA, and non-federal grants.  The laboratory has been pursuing a number of research projects with the common goal of understanding better HIV envelope-mediated immunity and pathogenesis in order to design more effective prophylactic and therapeutic measures against HIV.  The key projects currently active in the lab are as follows:

    1)                  Use of immune complexes as a vaccine strategy to elicit effective antibody and helper CD4 T cell responses against HIV.

    2)                  Evaluation of HIV neutralization by antibodies and biologic parameters influencing virus-neutralizing activities

    3)                  Modulation of HIV-1 envelope antigenicity and immunogenicity by glycosylation and antibodies

    4)                  HIV envelope-induced virological synapse and signaling