Publications:103
Chiara Giannarelli, MD, PhD
About Me
Dr. Chiara Giannarelli received her MD the University of Pisa, Italy. She completed her training in Internal Medicine and received her PhD in pharmacological sciences and pathophysiological mechanisms of cardiovascular disease at the University of Pisa, Italy. After completing her research fellowship at the Icahn School of Medicine at Mount Sinai she was recruited as Instructor in 2012 and then promoted to Assistant Professor in 2013. Her current research focuses into the identification of new molecular targets responsible for phenotypic switch of atherosclerotic plaques towards and advanced phenotype. She is now conducting translational and patient-oriented research using a Systems Biology approach to define new mechanisms and molecular targets for plaque instability in human samples from patients with clinically stable and unstable carotid and coronary disease.
Language
English
Position
ADJUNCT ASSOCIATE PROFESSOR | Medicine, Cardiology
Education
MD, University of Pisa
PhD, University of Pisa (Dept. of Pharmacology)
Post-Doctoral Fellow, Mount Sinai School of Medicine
Residency, University of Pisa
Awards
2017
The Role of P2X7 in HIV-Infected Individuals with Atherosclerotic Cardiovascular, Multidisciplinary Research Development Initiative
Department of Medicine, Icahn School of Medicine at Mount Sinai
2016
Dissecting the cellular and molecular immune interactions in human atherosclerosis
NIH-NHLBI
2016
NETWORK-DRIVEN DRUG REPURPOSING APPROACHES TO TREAT CORONARY ARTERY DISEASE
NIH-NCATS
2015
Multidisciplinary Research Development Initiative
Department of Medicine, Icahn School of Medicine at Mount Sinai
2013
Career Development Award
NIH-NHLBI
Research
We investigate the contribution of circulating monocyte subsets as a source of a new isoform of tissue factor with angiogenic activity to the growth of intimal neovessel in atherosclerosis as a potential mechanism of lesion instability culminating in the onset of ischemic cardiovascular events (i.e. stroke and myocardial infarction).
Publications
Selected Publications
- A Road Map to Understanding Cardiovascular Disease in Diabetes: From the AHA Strategically Focused Research Network in Cardiometabolic Health and Type 2 Diabetes. E. Dale Abel, Rexford S. Ahima, Ethan J. Anderson, David D. Berg, Jeffrey S. Berger, Saumya Das, Mark W. Feinberg, Edward A. Fisher, Michael S. Garshick, Chiara Giannarelli, Ira J. Goldberg, Naomi M. Hamburg, Sangwon F. Kim, Filipe A. Moura, Chiadi E. Ndumele, Jonathan D. Newman, Marc S. Sabatine, Elizabeth Selvin, Ravi Shah. Circulation Research
- Platelets impair the resolution of inflammation in atherosclerotic plaques in insulin-resistant mice after lipid lowering. Maria Laskou, Sofie Delbare, Michael Gildea, Ada Weinstock, Vitor De Moura Virginio, Maxwell La Forest, Franziska Krautter, Casey Donahoe, Letizia Amadori, Natalia Eberhardt, Tessa J. Barrett, Chiara Giannarelli, Jeffrey S. Berger, Edward A. Fisher. JCI insight
- A macrophage gene-regulatory network linked to clinical severity of coronary artery disease: The STARNET and NGS-PREDICT primary blood macrophage studies. Lijiang Ma, Jacqueline E. Tamis‑Holland, Giuseppe Mocci, Kathryn Wolhuter, Nicole S. Bryce, Swathy Sajja, Letizia Amadori, Payal Pradhan, Peik Sean Chong, Katyayani Sukhavasi, Haoxiang Cheng, Ling Li, Shichao Pang, Eric E. Schadt, Heribert Schunkert, Moritz von Scheidt, Arno Ruusalepp, Pedro R. Moreno, Ke Hao, Chiara Giannarelli, Clint L. Miller, Jason C. Kovacic, Johan L.M. Björkegren. Basic Research in Cardiology
Industry Relationships
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.
Dr. Giannarelli has not yet completed reporting of Industry relationships.
Mount Sinai’s faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.