Mount Sinai Health System
Search
Profile image of Christian Forst

    Christian Forst, PhD

    Education

    BS, University of Vienna

    MS, University of Vienna

    PhD, University of Vienna

    Awards

    2012

    Haberecht Wildhare-Idea Research Award

    UT Southwestern Medical Center

    2006

    Distinguished Performance Award

    Los Alamos National Laboratory

    1990

    Distinguished Performance Scholarship

    University of Vienna

    1989

    Elected student participant of 1989 Nobel Laureate Conference

    Research

    The overarching hypothesis of our proposed work is that diversity in virus strains, genetic immune epitopes, and responding immune cells contributes to heterogeneous outcomes of viral infection. By integrating existing large-scale single-cell and bulk transcriptomic data in SARS-CoV-2 and influenza infections, we are able to identify determinants of viral infections and key processes underlying viral replication, and immune response using integrative multi-scale network biology approaches. The research highlights the importance of identifying relevant key-immune processes at a single-cell resolution that control the infection and limit the extent of inflammatory damage. Such findings significantly improves therapeutic options in the fight against these threatening infectious diseases.