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Profile image of Christian Forst

    Christian Forst, PhD

    Education

    BS, University of Vienna

    MS, University of Vienna

    PhD, University of Vienna

    Awards

    2012

    Haberecht Wildhare-Idea Research Award

    UT Southwestern Medical Center

    2006

    Distinguished Performance Award

    Los Alamos National Laboratory

    1990

    Distinguished Performance Scholarship

    University of Vienna

    1989

    Elected student participant of 1989 Nobel Laureate Conference

    Research

    Unlike traditional biological research that focuses on a small set of  components, systems biology studies the complex interactions among a large number of genes, proteins and other elements of biological networks and systems. Host-Pathogen Systems Biology examines the interactions between the components of two distinct organisms: a microbial or viral pathogen and its animal host. With the availability of complete genomic sequences of a variety of hosts and pathogens, together with breakthroughs in proteomics, metabolomics and other experimental areas, the investigation of host-pathogen systems on a multitude of levels of detail has come within reach. 
     
    We are particularly interested the role of biochemical networks for the study of complex relationships across species boundaries. Although the research area of host-pathogen systems biology spans multiple spatial and temporal scales, we are focusing on the molecular and cellular aspect of pathogen-host interactions. Our research covers the construction of biochemical networks, the identification of functional response sub-networks and their comparative network analysis. These methods find application in the identification of host markers and drug targets for further drug development and therapeutic interventions.