Daniel Puleston, PhD

Daniel Puleston, PhD is an Assistant Professor of Oncological Sciences and a member of the Precision Immunology Institute and the Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai. Dr. Puleston received his doctorate and degrees in immunology from the University of Oxford followed by post-doctoral training at the Max Planck Institute for Immunology in Germany and Johns Hopkins University on a Sir Henry Wellcome Award. Dr. Puleston’s past work has elucidated how immune memory is formed and how poor long-lasting immunity in older individuals can be overcome by targeting cellular metabolism. His recent studies revealed how certain metabolic modalities are pivotal for the ability of T cells and macrophages to differentiate into distinct functional subsets – a key feature of immune cells facilitating their capacity to respond flexibly to numerous environmental threats. The Puleston Lab seeks to understand how metabolic factors shape immune cell function in healthy tissues and disease. Major research themes center around metabolic factors in tumor microenvironments including metabolic control of immune cell differentiation and acquisition of tissue-specific identities.