Publications:67
Dara L Dickstein, PhD
About Me
Dr. Dickstein is currently an Assistant Professor in the Department of Neuroscience at Mount Sinai School of Medicine. Her educational background is in molecular genetics and immunology. Her PhD work was focused on the role of inflammation in Alzheimer’s disease (AD) pathogenesis and utilized transgenic animal models along with various biochemical and anatomical techniques. Dr. Dickstein continued in the field of AD in her postdoctoral fellowship, exploring the structural changes in neurons and synapses with disease progression. Currently, Dr. Dickstein's research is directed towards the study of selective neuronal vulnerability in ageing, dementia, and other neurodegenerative disorders using classical neuropathological as well as modern quantitative methods. Dr. Dickstein has established much national and international collaboration, and has become an expert in the techniques of intracellular injections, fluorescence quantification, confocal and electron microscopy. Dr. Dickstein is a co-PL in the Alzheimer’s Disease Research Center at Mount Sinai and a member of the Computational Neurobiology and Imaging Center (CNIC) at Mount Sinai. As a member of CNIC, she has contributed to the creation of an automated quantitative software tool (NeuronStudio) that enables accurate 3D analysis of individual neurons in the brain at very high resolution.
Websites:
Language
English
Position
ADJUNCT ASSISTANT PROFESSOR | Neuroscience
Research Topics
Aging, Alzheimer's Disease, Blood-Brain Barrier, Cancer, Synapses, Transgenic Mice
Multi-Disciplinary Training Areas
Disease Mechanisms and Therapeutics (DMT), Neuroscience [NEU]
Education
PhD, University of British Columbia
Awards
2007
The Microcirculatory Society Wiederhelm Award
Research
Neurobiology of Ageing and Neurodegeneration
Research in the Dickstein lab focuses on the structural changes on neurons with ageing and disease. Our main research interests focus on Alzheimer’s disease and Parkinson’s disease, specifically targeting cells of the hippocampus and prefrontal cortex, areas crucial for cognition. We also investigate the effects of cancers and chemotherapy on neuronal and synapse integrity. We use a combination of transgenic mouse models, neuroanatomy, and confocal and electron microscopy to analyze the changes that neurons and synapses undergo during disease.
Research in the Dickstein lab focuses on the structural changes on neurons with ageing and disease. Our main research interests focus on Alzheimer’s disease and Parkinson’s disease, specifically targeting cells of the hippocampus and prefrontal cortex, areas crucial for cognition. We also investigate the effects of cancers and chemotherapy on neuronal and synapse integrity. We use a combination of transgenic mouse models, neuroanatomy, and confocal and electron microscopy to analyze the changes that neurons and synapses undergo during disease.
Publications
Selected Publications
- Structural plasticity of pyramidal cell neurons measured after FLASH and conventional dose-rate irradiation. Dara L. Dickstein, Richard Zhang, Ning Ru, Marie Catherine Vozenin, Bayley C. Perry, Juan Wang, Janet E. Baulch, Munjal M. Acharya, Charles L. Limoli. Brain Structure and Function
- Basic Science and Pathogenesis. Sam E. Gandy, Emilie L. Castranio, Merina Varghese, Elentina K. Argyrousi, Kuldeep Tripathi, Linda Söderberg, Erin Bresnahan, David Lerner, Francesca Garretti, Hong Zhang, Jonathan Van de Loo, Ronan Talty, Charles G. Glabe, Efrat Levy, Minghui Wang, Bin Zhang, Lars Lannfelt, William D. Lubell, Brigitte Guerin, Shai Rahimipour, Dara Dickstein, Ottavio Arancio, Michelle E. Ehrlich. Alzheimer's and Dementia
- The role of microglia in neuronal and cognitive function during high altitude acclimatization. Kathleen Hatch, Fritz Lischka, Mengfan Wang, Xiufen Xu, Cheryl D. Stimpson, Tara Barvir, Nathan P. Cramer, Daniel P. Perl, Guoqiang Yu, Caroline A. Browne, Dara L. Dickstein, Zygmunt Galdzicki. Scientific Reports
Industry Relationships
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.
Dr. Dickstein has not yet completed reporting of Industry relationships.
Mount Sinai’s faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.