
Daria V Lizneva, MD, PhD
About Me
Dr. Daria V. Lizneva, MD, PhD, is an Associate Professor at the Center for Translational Medicine and Pharmacology at the Icahn School of Medicine at Mount Sinai. Dr. Lizneva directs the Reproductive Biology Group within the Center. She is a clinician-scientist specializing in reproductive endocrinology, with a focus on understanding the phenotypes of disorders related to altered luteinizing hormone (LH) secretion, such as polycystic ovarian syndrome (PCOS), across diverse age and ethnic groups. Dr. Lizneva also engages in translational research on the non-traditional actions of LH and oxytocin.
Her research crosses international borders, bringing valuable insights into women's health on a global scale. Over the years, Dr. Lizneva has built a substantial research portfolio featuring investigations into the complex epidemiology and pathophysiology of PCOS across various age groups, ethnic backgrounds, and referral types—from clinical settings to general populations. Her approach utilizes epidemiological data, systematic reviews, and meta-analysis techniques.
Beyond her contributions to PCOS research, Dr. Lizneva has expanded her scope to explore the broader physiological implications of gonadotropin hormones. She has increasingly focused on the non-traditional roles of these hormones, particularly LH, and their effects on adipose tissue, neurocognition, and mood. This innovative work includes groundbreaking discoveries related to the action of the luteinizing hormone/chorionic gonadotropin receptor (LHCGR) in adipocytes, highlighting its potential as a therapeutic target for obesity. Her recent findings demonstrate that ORG43553, a small-molecule agonist for the LHCGR, can effectively prevent diet-induced obesity in wild-type mice while enhancing energy expenditure and oxygen consumption rates. She has filed for a U.S. patent for a method of treating obesity with an LHCGR agonist, underscoring her role at the forefront of translational medicine.
In addition to her research, Dr. Lizneva is a committed educator and mentor. She has guided many postdoctoral fellows, clinical fellows, medical students, and graduate students toward successful careers in biomedicine. Dr. Lizneva's contributions to medical science continually push the boundaries of knowledge and treatment strategies for complex endocrine disorders related to reproductive biology.
Language
English
Position
ASSOCIATE PROFESSOR | Pharmacological Sciences
Publications
Selected Publications
- Gene–dose-dependent reduction of Fshr expression improves spatial memory deficits in Alzheimer’s mice. Funda Korkmaz, Steven Sims, Fazilet Sen, Farhath Sultana, Victoria Laurencin, Liam Cullen, Anusha Pallapati, Avi Liu, Ronald Chen, Satish Rojekar, Georgii Pevnev, Uliana Cheliadinova, Darya Vasilyeva, Guzel Burganova, Anne Macdonald, Mansi Saxena, Ki Goosens, Clifford J. Rosen, Orly Barak, Daria Lizneva, Anisa Gumerova, Keqiang Ye, Vitaly Ryu, Tony Yuen, Tal Frolinger, Mone Zaidi. Molecular Psychiatry
- Ethnicity and the Prevalence of Polycystic Ovary Syndrome: The Eastern Siberia PCOS Epidemiology and Phenotype Study. Larisa Suturina, Daria Lizneva, Ludmila Lazareva, Irina Danusevich, Iana Nadeliaeva, Lilia Belenkaya, Alina Atalyan, Alexey Belskikh, Tatyana Bairova, Leonid Sholokhov, Maria Rashidova, Olga Krusko, Zorikto Darzhaev, Marina Rinchindorzhieva, Ayuna Malanova, Lilia Alekseeva, Eldar Sharifulin, Mikhail Kuzmin, Ilia Igumnov, Natalia Babaeva, Daria Tyumentseva, Ludmila Grebenkina, Nadezhda Kurashova, Marina Darenskaya, Elena Belyaeva, Natalia Belkova, Irina Egorova, Madinabonu Salimova, Ludmila Damdinova, Alexandra Sambyalova, Elena Radnaeva, Olesya Dyachenko, Karina Antsupova, Tatyana Trofimova, Anastasia Khomyakova, Kseniia Ievleva, Frank Z. Stanczyk, Richard S. Legro, Bulent O. Yildiz, Ricardo Azziz. Journal of Clinical Endocrinology and Metabolism
- Targeting FSH for osteoporosis, obesity, and Alzheimer's disease. Funda Korkmaz, Judit Gimenez-Roig, Farhath Sultana, Victoria Laurencin, Fasilet Sen, Liam Cullen, Steven Sims, Anusha Pallapati, Satish Rojekar, Guzel Burganova, Georgii Pevnev, Uliana Cheliadinova, Darya Vasilyeva, Ofer Moldavski, Tal Frolinger, Anisa Gumerova, Orly Barak, Vitaly Ryu, Daria Lizneva, Keqiang Ye, Anne Schafer, Clifford J. Rosen, Tony Yuen, Se Min Kim, Mone Zaidi. Trends in Molecular Medicine