Publications:56
Daria V Lizneva, MD, PhD
About Me
Dr. Daria V. Lizneva, MD, PhD, is an Associate Professor at the Center for Translational Medicine and Pharmacology at the Icahn School of Medicine at Mount Sinai. Dr. Lizneva directs the Reproductive Biology Group within the Center. She is a clinician-scientist specializing in reproductive endocrinology, with a focus on understanding the phenotypes of disorders related to altered luteinizing hormone (LH) secretion, such as polycystic ovarian syndrome (PCOS), across diverse age and ethnic groups. Dr. Lizneva also engages in translational research on the non-traditional actions of LH and oxytocin.
Her research crosses international borders, bringing valuable insights into women's health on a global scale. Over the years, Dr. Lizneva has built a substantial research portfolio featuring investigations into the complex epidemiology and pathophysiology of PCOS across various age groups, ethnic backgrounds, and referral types—from clinical settings to general populations. Her approach utilizes epidemiological data, systematic reviews, and meta-analysis techniques.
Beyond her contributions to PCOS research, Dr. Lizneva has expanded her scope to explore the broader physiological implications of gonadotropin hormones. She has increasingly focused on the non-traditional roles of these hormones, particularly LH, and their effects on adipose tissue, neurocognition, and mood. This innovative work includes groundbreaking discoveries related to the action of the luteinizing hormone/chorionic gonadotropin receptor (LHCGR) in adipocytes, highlighting its potential as a therapeutic target for obesity. Her recent findings demonstrate that ORG43553, a small-molecule agonist for the LHCGR, can effectively prevent diet-induced obesity in wild-type mice while enhancing energy expenditure and oxygen consumption rates. She has filed for a U.S. patent for a method of treating obesity with an LHCGR agonist, underscoring her role at the forefront of translational medicine.
In addition to her research, Dr. Lizneva is a committed educator and mentor. She has guided many postdoctoral fellows, clinical fellows, medical students, and graduate students toward successful careers in biomedicine. Dr. Lizneva's contributions to medical science continually push the boundaries of knowledge and treatment strategies for complex endocrine disorders related to reproductive biology.
Language
English
Position
ASSOCIATE PROFESSOR | Pharmacological Sciences
Publications
Selected Publications
- Neuroendocrine and neural control of bone mass in health and disease. Mone Zaidi, Se Min Kim, Vitaly Ryu, Daria Lizneva, Terry F. Davies, Clifford J. Rosen, Tony Yuen, Andrea Giustina. Journal of Clinical Investigation
- Fshr gene depletion prevents recognition memory loss, fat accrual and bone loss in Alzheimer’s mice. Uliana Cheliadinova, Steven Sims, Funda Korkmaz, Darya Vasilyeva, Victoria Laurencin, Judit Gimenez-Roig, Georgii Pevnev, Guzel Burganova, Zehra Tumoglu, Surabhi Parte, Farhath Sultana, Anusha R. Pallapati, Satish Rojekar, Anne Macdonald, Susan Hutchison, Avi Soussan, Anchine Liu, Yi Wei, Ofer Moldavski, Anisa Gumerova, Weibin Zhou, Orly Barak, Ki A. Goosens, Vitaly Ryu, Daria Lizneva, Clifford J. Rosen, Tony Yuen, Tal Frolinger, Mone Zaidi. Molecular Psychiatry
- Targeting FSH for osteoporosis, obesity, and Alzheimer’s disease. Funda Korkmaz, Judit Gimenez-Roig, Farhath Sultana, Victoria Laurencin, Fasilet Sen, Liam Cullen, Steven Sims, Anusha Pallapati, Satish Rojekar, Guzel Burganova, Georgii Pevnev, Uliana Cheliadinova, Darya Vasilyeva, Ofer Moldavski, Tal Frolinger, Anisa Gumerova, Orly Barak, Vitaly Ryu, Daria Lizneva, Keqiang Ye, Anne Schafer, Clifford J. Rosen, Tony Yuen, Se Min Kim, Mone Zaidi. Trends in Molecular Medicine
Industry Relationships
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.
Dr. Lizneva has not yet completed reporting of industry relationships or has no industry relationships to report.
Mount Sinai’s faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.