
Denise Cai, PhD
About Me
Dr. Denise Cai joined the Department of Neuroscience at the Friedman Brain Institute in 2017 and has been an Associate Professor since 2022. Her lab combines cellular, circuit, and behavioral techniques to study how memories are stably stored and flexibly updated across time and experience. By studying memory-linking, or how events are connected when they occur closely in the time, she hopes to understand memory disorders such as post-traumatic stress disorder. Dr. Cai is also a leader in the development of open-source neuroscience recording and analysis tools, such as Miniscope – a miniature microscope for calcium imaging in freely behaving rodents.
Prior to joining the faculty at Icahn School of Medicine, Dr. Cai was a postdoctoral fellow at the University of California Los Angeles, where she originally began her work on Miniscope. She completed her PhD in Experimental Psychology & Behavioral Neuroscience at the University of California, San Diego, where she studied the role of sleep in memory in humans and mice. Her work has been recognized with several awards and honors including Allen Institute Next Generation Leaders Council, One Mind Rising Star Award, NARSAD Young Investigator Award, Brain and Behavior Research Foundation Young Investigator Award, among others. For more information about Dr. Cai, visit https://www.denisecailab.com/.
Language
English
Position
ASSOCIATE PROFESSOR | Neuroscience
Multi-Disciplinary Training Areas
Neuroscience [NEU]
Education
PhD, University of California, San Diego
Awards
2023
Friedman Brain Institute Scholar Award
2022
American College of Neuropsychopharmacology Member
2021
Irma T. Hirschl/Monique Weill-Caulier Research Award
2020
Optogenetics GRC, Vice Chair, 2020 and Chair, 2022
2020
Mount Sinai Distinguished Scholar Award
Icahn School of Medicine at Mount Sinai
2019
NIMH Research Grant (R01)
NIMH
2019
NIH Director’s New Innovator Award (DP2)
2019
McKnight Memory and Cognitive Disorder Award
2019
NARSAD Young Investigator Award
2018
Botanical Center Pilot Award
2018
Brain Research Foundation Award
2018
Klingenstein-Simons Fellowship Award
2018
Friedman Brain Scholar Award
2018
Outstanding Teaching Award
Icahn School of Medicince at Mount Sinai
2017
Allen Institute Next Generation Leader
2016
One Mind Otsuka Rising Star Award
Research
These are some of the captivating—and complex— questions about learning and memory we’re exploring in our lab. We use a multi-level approach integrating molecular, cellular, circuit-level, and behavioral techniques to investigate the dynamic nature of memory. Our primary research themes include memory capacity, temporal memory-linking, and sleep and memory. We’re studying the strategies the brain uses to optimize its capacity for storage; how prior learning influences future behavior; and why emotions may alter memories while we sleep. Building and sharing novel tools and technologies to help answer these and evolving questions in neuroscience is an exciting part of our lab’s work. We’re passionate about the open-source movement and committed to building a collaborative and generous neuroscience community.
Behavior, In Vivo Imaging, Learning & Memory, Cognitive Disorders, Hippocampus, Age-related Cognitive Deficits, Anxiety-related Disorders, Optogenetics, Chemogenetics, Activity-dependent Tagging
Publications
Selected Publications
- A comprehensive suite for extracting neuron signals across multiple sessions in one-photon calcium imaging. Pablo Vergara, Yuteng Wang, Sakthivel Srinivasan, Zhe Dong, Yu Feng, Iyo Koyanagi, Deependra Kumar, Yoan Chérasse, Toshie Naoi, Yuki Sugaya, Takeshi Sakurai, Masanobu Kano, Tristan Shuman, Denise Cai, Masashi Yanagisawa, Masanori Sakaguchi. Nature Communications
- Simultaneous two-color imaging with a dual-channel miniscope in freely behaving mice. Zhe Dong, Yu Feng, Keziah Diego, Austin M. Baggetta, Brian M. Sweis, Zachary T. Pennington, Sophia I. Lamsifer, Yosif Zaki, Federico Sangiuliano, Paul A. Philipsberg, Denisse Morales-Rodriguez, Daniel Kircher, Paul Slesinger, Tristan Shuman, Daniel Aharoni, Denise J. Cai. Science advances
- Neuron-Specific Glycine Metabolism Links Transfer RNA Epitranscriptomic Regulation to Complex Behaviors. Jennifer Blaze, Viviana Dolores Evans, Jessica Abigail Feria Pliego, Petr Unichenko, Behnam Javidfar, Soeren Heissel, Hanan Alwaseem, Zachary Pennington, Denise Cai, Henrik Molina, Christian Henneberger, Schahram Akbarian. Biological Psychiatry Global Open Science