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Profile image of Denise Cai

    Denise Cai, PhD

    Education

    PhD, University of California, San Diego

    Awards

    2023

    Friedman Brain Institute Scholar Award

    2022

    American College of Neuropsychopharmacology Member

    2021

    Irma T. Hirschl/Monique Weill-Caulier Research Award

    2020

    Optogenetics GRC, Vice Chair, 2020 and Chair, 2022

    2020

    Mount Sinai Distinguished Scholar Award

    Icahn School of Medicine at Mount Sinai

    2019

    NIMH Research Grant (R01)

    NIMH

    2019

    NIH Director’s New Innovator Award (DP2)

    2019

    McKnight Memory and Cognitive Disorder Award

    2019

    NARSAD Young Investigator Award

    2018

    Botanical Center Pilot Award

    2018

    Brain Research Foundation Award

    2018

    Klingenstein-Simons Fellowship Award

    2018

    Friedman Brain Scholar Award

    2018

    Outstanding Teaching Award

    Icahn School of Medicince at Mount Sinai

    2017

    Allen Institute Next Generation Leader

    2016

    One Mind Otsuka Rising Star Award

    Research

    If we live long enough, will our brains one day simply “max out” and run out of room, and if not, why not? Are memories formed and stored differently in the brain as we age? How does the way in which memories are linked over time affect what we remember? What role does sleep play in linking memories across time?

    These are some of the captivating—and complex— questions about learning and memory we’re exploring in our lab. We use a multi-level approach integrating molecular, cellular, circuit-level, and behavioral techniques to investigate the dynamic nature of memory. Our primary research themes include memory capacity, temporal memory-linking, and sleep and memory. We’re studying the strategies the brain uses to optimize its capacity for storage; how prior learning influences future behavior; and why emotions may alter memories while we sleep. Building and sharing novel tools and technologies to help answer these and evolving questions in neuroscience is an exciting part of our lab’s work. We’re passionate about the open-source movement and committed to building a collaborative and generous neuroscience community.
    Behavior, In Vivo Imaging, Learning & Memory, Cognitive Disorders, Hippocampus, Age-related Cognitive Deficits, Anxiety-related Disorders, Optogenetics, Chemogenetics, Activity-dependent Tagging