
Diego Chowell, PhD
About Me
Dr. Chowell is a scientist working on problems at the intersection of cancer genomics, immunology, and computational biology. His lab applies approaches from computational biology and machine learning to unravel the molecular determinants of response to immune checkpoint blockade therapy, understand the co-evolution of tumor cells and the human immune system during cancer evolution, and learn the complex rules that govern T cell epitope recognition and immune escape.
He earned his PhD in applied mathematics from Arizona State University and a Master Class Fellowship from Utrecht University, The Netherlands, where he worked on dynamical systems and chaos theory. Dr. Chowell spent a year as a visiting graduate student at the Moe Win Laboratory for Information and Decision Systems at MIT. He was a postdoctoral research fellow in the Timothy Chan Lab at Memorial Sloan Kettering Cancer Center.
Visit the Chowell Laboratory
Language
English
Position
ASSISTANT PROFESSOR | Artificial Intelligence and Human Health, ASSISTANT PROFESSOR | Immunology & Immunotherapy, ASSISTANT PROFESSOR | Oncological Sciences
Research Topics
Cancer, Computational Biology, Immunology
Multi-Disciplinary Training Areas
Artificial Intelligence and Emerging Technologies in Medicine [AIET], Genetics and Genomic Sciences [GGS], Immunology [IMM]
Publications
Selected Publications
- T cell epitope mapping reveals immunodominance of evolutionarily conserved regions within SARS-CoV-2 proteome. Cansu Cimen Bozkus, Matthew Brown, Leandra Velazquez, Marcus Thomas, Eric A. Wilson, Timothy O'Donnell, Anna Kaminska, Denis Ruchnewitz, Douglas Geertz, Yonina Bykov, Julia Kodysh, Kasopefoluwa Y. Oguntuyo, Vladimir Roudko, David Hoyos, Komal D. Srivastava, Giulio Kleiner, Hala Alshammary, Neha Karekar, Christopher McClain, Ramya Gopal, Kai Nie, Diane Del Valle, Daniela Delbeau-Zagelbaum, Denise Rodriguez, Jessica Setal, Emily Carroll, Margrit Wiesendanger, Percio S. Gulko, Alexander Charney, Miriam Merad, Seunghee Kim-Schulze, Benhur Lee, Ania Wajnberg, Viviana Simon, Benjamin D. Greenbaum, Diego Chowell, Nicolas Vabret, Marta Luksza, Nina Bhardwaj. iScience
- Restoring resident tissue macrophages to combat aging and cancer. Matthew D. Park, Nader Yatim, Jing Zhang, Byuri Angela Cho, Seong Keun Yoo, Maximilian M. Schaefer, Diego Chowell, Daniel J. Puleston, Miriam Merad. Nature Aging
- Genetic immune escape in cancer: timing and implications for treatment. Francisco Martínez-Jiménez, Diego Chowell. Trends in Cancer