Publications:50
Diego Chowell, PhD
About Me
Dr. Chowell is a scientist working on problems at the intersection of cancer genomics, immunology, and computational biology. His lab applies approaches from computational biology and machine learning to unravel the molecular determinants of response to immune checkpoint blockade therapy, understand the co-evolution of tumor cells and the human immune system during cancer evolution, and learn the complex rules that govern T cell epitope recognition and immune escape.
He earned his PhD in applied mathematics from Arizona State University and a Master Class Fellowship from Utrecht University, The Netherlands, where he worked on dynamical systems and chaos theory. Dr. Chowell spent a year as a visiting graduate student at the Moe Win Laboratory for Information and Decision Systems at MIT. He was a postdoctoral research fellow in the Timothy Chan Lab at Memorial Sloan Kettering Cancer Center.
Visit the Chowell Laboratory
Language
English
Position
ASSISTANT PROFESSOR | Artificial Intelligence and Human Health, ASSISTANT PROFESSOR | Immunology & Immunotherapy, ASSISTANT PROFESSOR | Oncological Sciences
Research Topics
Cancer, Computational Biology, Immunology
Multi-Disciplinary Training Areas
Artificial Intelligence and Emerging Technologies in Medicine [AIET], Genetics and Genomic Sciences [GGS], Immunology [IMM]
Publications
Selected Publications
- Higher HLA-DRB1 Evolutionary Divergence Is Associated with Reduced Relapse and Improved Survival after Matched Unrelated Hematopoietic Cell Transplantation. Jennifer N. Saultz, Yung Tsi Bolon, Tao Wang, Stephen R. Spellman, Stephanie J. Lee, Meilun He, Christine Camacho-Bydume, Chirag Krishna, Diego Chowell, Brian C. Shaffer, Katharine C. Hsu, Sophie Paczesny, Shahinaz M. Gadalla, Steven G.E. Marsh, Brian C. Betts, Esteban Arrieta-Bolaños. Transplantation and Cellular Therapy
- Monitoring of plasma and urine tumor-derived DNA to inform bladder-sparing approaches for patients with muscle-invasive bladder cancer. Matthew D. Galsky, Sudeh Izadmehr, Menggang Yu, Samuel D. Curtis, Christopher Douville, Maria Popoli, Janine Ptak, Lisa Dobbyn, Natalie Silliman, Kevin G. Chan, Tanya B. Dorff, Jeremy P. Cetnar, Brock O’Neil, Anishka D’Souza, Ronac Mamtani, Christos E. Kyriakopoulos, Rachel Brody, Evita Sadimin, Reza Mehrazin, Diego Chowell, John Sfakianos, Siamak Daneshmand, Sumanta K. Pal, Chetan Bettegowda, Kenneth W. Kinzler, Nickolas Papadopoulos, Bert Vogelstein, Yuxuan Wang. Proceedings of the National Academy of Sciences of the United States of America
- T cell epitope mapping reveals immunodominance of evolutionarily conserved regions within SARS-CoV-2 proteome. Cansu Cimen Bozkus, Matthew Brown, Leandra Velazquez, Marcus Thomas, Eric A. Wilson, Timothy O'Donnell, Anna Kaminska, Denis Ruchnewitz, Douglas Geertz, Yonina Bykov, Julia Kodysh, Kasopefoluwa Y. Oguntuyo, Vladimir Roudko, David Hoyos, Komal D. Srivastava, Giulio Kleiner, Hala Alshammary, Neha Karekar, Christopher McClain, Ramya Gopal, Kai Nie, Diane Del Valle, Daniela Delbeau-Zagelbaum, Denise Rodriguez, Jessica Setal, Emily Carroll, Margrit Wiesendanger, Percio S. Gulko, Alexander Charney, Miriam Merad, Seunghee Kim-Schulze, Benhur Lee, Ania Wajnberg, Viviana Simon, Benjamin D. Greenbaum, Diego Chowell, Nicolas Vabret, Marta Luksza, Nina Bhardwaj. iScience
Industry Relationships
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.
Dr. Chowell has not yet completed reporting of Industry relationships.
Mount Sinai’s faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.