Publications:91
Donghoon Lee, PhD
About Me
Donghoon Lee is an Assistant Professor of the Department of Genetics and Genomic Sciences and the Department of Psychiatry at the Icahn School of Medicine at Mount Sinai. He currently serves as the Director of Single Cell Neurogenomics Group at the Center for Disease Neurogenomics (CDN).
His research is focused on computational psychiatric genomics. Leveraging the wealth of single-nucleus and functional genomic data, he is developing new methodologies for understanding the genetic basis of neuropsychiatric and neurodegenerative disorders.
Prior to joining the Icahn School of Medicine at Mount Sinai, Dr. Lee received his doctorate degree and postdoctoral training from Yale University.
Language
English
Position
ASSISTANT PROFESSOR | Genetics and Genomic Sciences, ASSISTANT PROFESSOR | Psychiatry
Research Topics
Alzheimer's Disease, Bioinformatics, Brain, Computational Biology, Epigenomics, Genetics, Genomics, Microglia, Neural Networks, Neuroscience, Psychiatry
Education
PhD, Yale University
Postdoc, Yale University
BS, Washington University
Publications
Selected Publications
- SECmeres outperform extracellular vesicles as potential blood RNA biomarkers for Alzheimer’s disease. Edgar Gonzalez-Kozlova, Swapnil Tichkule, Yohei Nose, Tzu Yi Chen, Eduard Reznik, Juliet V. Santiago, Anish Korrapati, Taliah Soleymani, Roman Kosoy, Igor Figueiredo, Donghoon Lee, Gabriel E. Hoffman, Natasha Kyprianou, Ronald E. Gordon, Carlos Cordon-Cardo, Srikant Rangaraju, Nicholas T. Seyfried, Vahram Haroutunian, John F. Fullard, Panos Roussos, Navneet Dogra. Nature Communications
- Cholesterol dysregulation in APOE4 astrocytes promotes α-synuclein pathology in miBrains. Louise A. Mesentier-Louro, Camille Goldman, Sebastian Gaese, Alice Buonfiglioli, Dimitrios Kyriakis, Ashley Harlock, Alain Ndayisaba, Emily R. Sartori, Abigail Uchitelev, John F. Fullard, Evelyn Hennigan, Donghoon Lee, Braxton R. Schuldt, Rikki B. Rooklin, Jonathan Barra, Jose Javier Bravo-Cordero, Panos Roussos, Vikram Khurana, Joel W. Blanchard. Cell Stem Cell
- Plasticity of human microglia and brain perivascular macrophages in aging and Alzheimer’s disease. Donghoon Lee, James M. Vicari, Christian Porras, Collin Spencer, Milos Pjanic, Xinyi Wang, Seon Kinrot, Philipp Weiler, Roman Kosoy, Jaroslav Bendl, Prashant N M, Konstantina Psychogyiou, Periklis Malakates, Evelyn Hennigan, Jennifer Monteiro Fortes, Shiwei Zheng, Karen Therrien, Deepika Mathur, Steven P. Kleopoulos, Zhiping Shao, Stathis Argyriou, Marcela Alvia, Clara Casey, Aram Hong, Kristin G. Beaumont, Robert Sebra, Christopher P. Kellner, David A. Bennett, Guo Cheng Yuan, Georgios Voloudakis, Fabian J. Theis, Vahram Haroutunian, Gabriel E. Hoffman, John F. Fullard, Panos Roussos. Nature Genetics
Industry Relationships
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.
Dr. Lee has not yet completed reporting of industry relationships or has no industry relationships to report.
Mount Sinai’s faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.