Eileen Kemether, MD

The study of the transcriptome of cells from various thalamic regions in schizophrenia versus non-psychiatric control postmortem samples.   The comparison of the whole human genome transcriptome of cells from one thalamic region in schizophrenia, bipolar mood disorder, depression versus non-psychiatric controls.  These studies employ laser capture microdissection to isolate the cells for high throughput microarray analysis in collaboration with Dr. Tearina Chu.  We will compare transcriptome findings from medial tier thalamic regions that have been implicated in schizophrenia with a lateral tier nucleus in the same subject.  A large scale qPCR validation study is ongoing.