Publications:50
Elena Ezhkova, PhD
About Me
Dr. Elena Ezhkova is a Professor of Stem Cell Biology and Regenerative Medicine and Dermatology. She is Director of the Skin Biology and Diseases Resource-based Center (SBDRC) at Mount Sinai. She is a member of the Tisch Cancer Center.
The Ezhkova Lab studies how skin stem cells maintain healthy tissue, regenerate after injury, and contribute to aging and disease. Our research spans hair growth and regeneration, wound healing, skin aging, touch and chronic itch, and skin cancer. We investigate how epigenetic mechanisms control stem cell behavior, how communication between skin cells and nerves regulates sensation and itch, and how these processes become disrupted in cancer. Our cancer research focuses on squamous cell carcinoma and Merkel cell carcinoma, including the development of new disease models and therapeutic approaches. Ultimately, our goal is to translate discoveries about basic skin biology into new strategies for regeneration and treatment of skin diseases.
We are recruiting graduate students and postdoctoral fellows!
For more information, please visit our website: https://www.ezhkova-lab.com/
Folow us on Twitter : https://twitter.com/EzhkovaLab
Language
English
Position
PROFESSOR | Stem Cell Biology And Regenerative Medicine, PROFESSOR | Dermatology
Research Topics
Cancer, Cellular Differentiation, Chromatin, Developmental Biology, Epigenetics, Epithelial Cells, Neuronal Regeneration, Skin Cancer, Stem Cells
Multi-Disciplinary Training Areas
Cancer Biology [CAB], Development Regeneration and Stem Cells [DRS], Genetics and Genomic Sciences [GGS], Neuroscience [NEU]
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Ph.D., Cold Spring Harbor Laboratory
Postdoc, Rockefeller University
Publications
Selected Publications
- Oncogenic Ras drives EED degradation and PRC2 dysfunction to promote aggressive squamous cell carcinoma. Meng Yen Li, Aubrey Houser, Pradeep Cheema, Xiang Yu Zheng, Paula Restrepo, Pooja Flora, Yudong Zhou, Gil Segal-Dalal, Eldad Silberstein, Xiaotao Zhang, Markus Schober, Deyou Zheng, Idan Cohen, Andrew L. Ji, Elena Ezhkova. Nature Communications
- Transcription and potential functions of a novel XIST isoform in male peripheral glia. Kevin S. O’Leary, Meng Yen Li, Kevyn Jackson, Lijie Shi, Elena Ezhkova, Bernice E. Morrow, Deyou Zheng. Genome Research
- H2AK119ub dynamics control hair follicle stem cell quiescence. Pooja Flora, Meng Yen Li, Yudong Zhou, Maria Mercédes, Xiang Yu Zheng, Phillip M. Galbo, Deyou Zheng, Elena Ezhkova. Nature Communications
Industry Relationships
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.
Dr. Ezhkova has not yet completed reporting of industry relationships or has no industry relationships to report.
Mount Sinai’s faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.