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    Emily Bernstein, PhD

    Education

    PhD, SUNY Stony Brook/Cold Spring Harbor Laboratory

    , The Rockefeller University

    Awards

    2020

    Faculty Council Award for Academic Excellence by a Senior Faculty member

    Icahn School of Medicine at Mount Sinai

    2019

    4D Technology Development Program

    Mount Sinai Innovation Award

    2017

    Commencement 2017 Honoree, Graduate Student Marshal

    Icahn School of Medicine at Mount Sinai

    2015

    Established Investigator Award

    Melanoma Research Alliance

    2014

    Young Investigators in Cancer Research

    Pershing Square Sohn Prize

    2012

    Outstanding Mentorship Award

    Mount Sinai Graduate School

    2012

    Young Cancer Scientist Research Award

    JJR Foundation

    2012

    Developmental Fund Award

    The Tisch Cancer Institute at Mount Sinai

    2011

    The Dr. Harold and Golden Lamport Research Award

    Icahn School of Medicine at Mount Sinai

    2010

    Tisch Cancer Institute Developmental Funds Award

    Icahn School of Medicine at Mount Sinai

    2008

    Scholar Award

    American Skin Association Research

    2008

    New Scholar Award

    Ellison Medical Foundation

    2004

    Postdoctoral Fellowship

    National Science Foundation

    Research Award

    Irma T. Hirschl Charitable Trust

    Research


    Summary of Current Research

    Our focus is on epigenetic regulation of gene expression in multiple biological pathways including cancer (melanoma, breast cancer, neuroblastoma), cellular senescence and stem cell biology. We have a strong research focus on histone variants and their dedicated chaperones, chromatin remodelers, and histone modifying enzymes, which are all frequently altered in cancer.

    Chromatin is the complex of DNA and its intimately associated proteins - with histones constituting the major component. This template is an attractive candidate for shaping the features of a cell's epigenetic landscape. Disruption of a cell's epigenetic balance can perturb chromatin structure and gene regulation, contributing to disease states. There is a growing interest both in academia and industry to target the machinery that regulate chromatin dynamics, and this burgeoning field is of great interest to our laboratory.

    Our laboratory collaborates with numerous investigators at ISMMS and other institutes to translate our basic mechanistic findings towards pre-clinical or clinical trials. We work closely with medicinal chemists, immunologists, and external partners towards this goal.

    Visit the Bernstein Laboratory