Publications:87
Emily Bernstein, PhD
About Me
Emily Bernstein, PhD, is Professor and Vice Chair of the Department of Oncological Sciences at the Icahn School of Medicine at Mount Sinai. Dr. Bernstein is also Co-leader of the Cancer Mechanisms Research Program at The Tisch Cancer Institute. As such, Dr. Bernstein facilitates basic research on genetic, epigenetic, biochemical, and developmental pathways that drive cancer initiation and progression, and fosters intra- and inter-program collaborations that accelerate the development of novel, targeted therapies for cancer.
Dr. Bernstein’s laboratory studies the epigenetic regulation of gene expression in cancer and development, with the long-term goal of understanding the chromatin changes that take place at the molecular level during the transformation process of normal cells to cancer cells. Her team studies melanoma skin cancer, and pediatric cancers such as neuroblastoma.
Dr. Bernstein teaches courses on cancer biology and serves on numerous PhD thesis committees at the Icahn School of Medicine at Mount Sinai. She served as a member of the Cancer Genetics Study Section of the NIH Center for Scientific Review, serves as a standing reviewer for multiple research grant foundations and is an Associate Editor for the journal Science Advances.
Language
English
Position
PROFESSOR | Oncological Sciences, PROFESSOR | Dermatology
Research Topics
Cancer, Chromatin, Epigenetics, Gene Regulation, Molecular Biology, Stem Cells
Multi-Disciplinary Training Areas
Cancer Biology [CAB], Development Regeneration and Stem Cells [DRS]
Education
PhD, SUNY Stony Brook/Cold Spring Harbor Laboratory
, The Rockefeller University
Awards
2020
Faculty Council Award for Academic Excellence by a Senior Faculty member
Icahn School of Medicine at Mount Sinai
2019
4D Technology Development Program
Mount Sinai Innovation Award
2017
Commencement 2017 Honoree, Graduate Student Marshal
Icahn School of Medicine at Mount Sinai
2015
Established Investigator Award
Melanoma Research Alliance
2014
Young Investigators in Cancer Research
Pershing Square Sohn Prize
2012
Outstanding Mentorship Award
Mount Sinai Graduate School
2012
Young Cancer Scientist Research Award
JJR Foundation
2012
Developmental Fund Award
The Tisch Cancer Institute at Mount Sinai
2011
The Dr. Harold and Golden Lamport Research Award
Icahn School of Medicine at Mount Sinai
2010
Tisch Cancer Institute Developmental Funds Award
Icahn School of Medicine at Mount Sinai
2008
Scholar Award
American Skin Association Research
2008
New Scholar Award
Ellison Medical Foundation
2004
Postdoctoral Fellowship
National Science Foundation
Research Award
Irma T. Hirschl Charitable Trust
Research
Summary of Current Research
Our focus is on epigenetic regulation of gene expression in multiple biological pathways including cancer (melanoma, breast cancer, neuroblastoma), cellular senescence and stem cell biology. We have a strong research focus on histone variants and their dedicated chaperones, chromatin remodelers, and histone modifying enzymes, which are all frequently altered in cancer.
Chromatin is the complex of DNA and its intimately associated proteins - with histones constituting the major component. This template is an attractive candidate for shaping the features of a cell's epigenetic landscape. Disruption of a cell's epigenetic balance can perturb chromatin structure and gene regulation, contributing to disease states. There is a growing interest both in academia and industry to target the machinery that regulate chromatin dynamics, and this burgeoning field is of great interest to our laboratory.
Our laboratory collaborates with numerous investigators at ISMMS and other institutes to translate our basic mechanistic findings towards pre-clinical or clinical trials. We work closely with medicinal chemists, immunologists, and external partners towards this goal.
Publications
Selected Publications
- SETDB1 is critically required for uveal melanoma growth and represents a promising therapeutic target. Imène Krossa, Céline Pisibon, Yann Cheli, Karine Bille, Mélanie Dalmasso, Sabah Hamadat, Chrystel Husser, Marie Irondelle, Julien Cherfils-Vicini, Frédéric Soysouvanh, Sacha Nahon-Esteve, Arnaud Martel, Sandra Lassalle, Jean Pierre Caujolle, Célia Maschi, Stéphanie Baillif, Dan Hasson, Saul Carcamo, Andrew E. Aplin, Irwin Davidson, Emily Bernstein, Valeria Naim, Robert Ballotti, Corine Bertolotto, Thomas Strub. Cell Death and Disease
- Loss of histone macroH2A1.1 causes kidney abnormalities secondary to a change in nutrient metabolization. René Winkler, Gemma Comas-Armangué, David Corujo, Adrián Sanz-Moreno, Julia Calzada-Wack, Shubhra Ashish Bhattacharya, Birgit Rathkolb, Nathalia Romanelli Vicente Dragano, Colina X. Qiao, Valentina Chiodi, Dan Filipescu, Dylan H. Park, Maria Rosaria Domenici, Valentina Kirigin Callaú, Raffaele Gerlini, Jan Rozman, Tanja Klein-Rodewald, Antonio Aguilar-Pimentel, Lore Becker, Claudia Seisenberger, Susan Marschall, Helmut Fuchs, Valérie Gailus-Durner, Emily Bernstein, Manlio Vinciguerra, Philipp Oberdoerffer, Martin Hrabě de Angelis, Raffaele Teperino, Marcus Buschbeck. Science advances
- A needed nomenclature for nucleosomes. Michael Christopher Keogh, Genevieve Almouzni, Andrew J. Andrews, Karim Jean Armache, Cheryl H. Arrowsmith, Sung Hee Baek, Mark T. Bedford, Emily Bernstein, Jacques Côté, Yael David, John M. Denu, Beat Fierz, Benjamin A. Garcia, Karen C. Glass, Or Gozani, Kristian Helin, Steven Henikoff, Ole N. Jensen, Steven Z. Josefowicz, Neil L. Kelleher, Tatiana G. Kutateladze, Herbert H. Lindner, Chao Lu, Karolin Luger, Parag Mallick, Catherine A. Musselman, Tom W. Muir, Ljiljana Paša-Tolić, Robert Schneider, Xiaobing Shi, Yang Shi, Simone Sidoli, Lloyd M. Smith, Jessica K. Tyler, Cynthia Wolberger, Jerry L. Workman, Brian D. Strahl, Nicolas L. Young. Molecular Cell