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Mount Sinai DoctorsEric J Nestler, MD, PhD
Psychiatry
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About Me
Dr. Nestler is the Nash Family Professor of Neuroscience, Director of the Friedman Brain Institute, and Dean for Academic Affairs at the Icahn School of Medicine at Mount Sinai and Chief Scientific Officer of the Mount Sinai Health System. His laboratory studies the molecular mechanisms of drug addiction and depression in animal models.
Visit Eric Nestler's Laboratory of Molecular Psychiatry and NIDA Program Project Grant for more information.
Language
Position
Hospital Affiliations
- Mount Sinai Queens
- The Mount Sinai Hospital
Research Topics
Addiction, Behavioral Health, Depression, Epigenetics, Molecular Biology, Neuroscience, Stress, Synapses, Synaptic Plasticity, Synaptogenesis
Multi-Disciplinary Training Areas
Disease Mechanisms and Therapeutics (DMT), Neuroscience [NEU]
About Me
Dr. Nestler is the Nash Family Professor of Neuroscience, Director of the Friedman Brain Institute, and Dean for Academic Affairs at the Icahn School of Medicine at Mount Sinai and Chief Scientific Officer of the Mount Sinai Health System. His laboratory studies the molecular mechanisms of drug addiction and depression in animal models.
Visit Eric Nestler's Laboratory of Molecular Psychiatry and NIDA Program Project Grant for more information.
Language
Position
Hospital Affiliations
- Mount Sinai Queens
- The Mount Sinai Hospital
Research Topics
Addiction, Behavioral Health, Depression, Epigenetics, Molecular Biology, Neuroscience, Stress, Synapses, Synaptic Plasticity, Synaptogenesis
Multi-Disciplinary Training Areas
Disease Mechanisms and Therapeutics (DMT), Neuroscience [NEU]
About Me
Dr. Nestler is the Nash Family Professor of Neuroscience, Director of the Friedman Brain Institute, and Dean for Academic Affairs at the Icahn School of Medicine at Mount Sinai and Chief Scientific Officer of the Mount Sinai Health System. His laboratory studies the molecular mechanisms of drug addiction and depression in animal models.
Visit Eric Nestler's Laboratory of Molecular Psychiatry and NIDA Program Project Grant for more information.
Language
Position
Hospital Affiliations
- Mount Sinai Queens
- The Mount Sinai Hospital
Research Topics
Addiction, Behavioral Health, Depression, Epigenetics, Molecular Biology, Neuroscience, Stress, Synapses, Synaptic Plasticity, Synaptogenesis
Multi-Disciplinary Training Areas
Disease Mechanisms and Therapeutics (DMT), Neuroscience [NEU]
Video
Education
MD, Yale University School of Medicine
PhD, Yale University
Internship, Psychiatry
McLean Hospital
Residency, Psychiatry
Yale University School of Medicine
Fellowship, Clinical Pharmacology
Yale University School of Medicine
Fellowship, Psychiatry
Yale University School of Medicine
Awards
2019
Redelsheimer Distinguished Research Award, Society of Biological Psychiatry
2017
Wilbur Cross Distinguished Alumnus Medal, Yale University
2017
Paul Hoch Distinguished Service Award
2010
Sarnat Prize, Institute of Medicine
2005
American Academy of Arts and Science
1998
Institute of Medicine (National Academy of Medicine)
Research
Nestler Lab, Laboratory of Molecular Psychiatry
Specific Clinical/Research Interest: Molecular neurobiology of drug addiction and depression; transcriptional and epigenetic regulation in the brain.
Our research focuses on identifying the neurobiological basis of drug addiction and depression in rodent models. We study the molecular and cellular changes that occur in regions of the brain important for reward and motivation in response to chronic administration of a drug of abuse or chronic exposure to stress. We are particularly interested in long-lasting changes that are mediated via alterations in gene expression and chromatin remodeling. The result of the research will guide future efforts toward the development of more effective treatments for addiction and depression.
Current Team
For a complete list of publications, please visit Selected Publications.
For more, please visit the Nestler Lab.
Specific Clinical/Research Interest: Molecular neurobiology of drug addiction and depression; transcriptional and epigenetic regulation in the brain.
Our research focuses on identifying the neurobiological basis of drug addiction and depression in rodent models. We study the molecular and cellular changes that occur in regions of the brain important for reward and motivation in response to chronic administration of a drug of abuse or chronic exposure to stress. We are particularly interested in long-lasting changes that are mediated via alterations in gene expression and chromatin remodeling. The result of the research will guide future efforts toward the development of more effective treatments for addiction and depression.
Current Team
For a complete list of publications, please visit Selected Publications.
For more, please visit the Nestler Lab.
Insurance Information
Physicians who provide services at hospitals and facilities in the Mount Sinai Health System might not participate in the same health plans as those Mount Sinai hospitals and facilities (even if the physicians are employed or contracted by those hospitals or facilities).
Information regarding insurance participation and billing by this physician may be found on this page, and can also be obtained by contacting this provider directly. Because physicians insurance participation can change, the insurance information on this page may not always be up-to-date. Please contact this physician directly to obtain the most up-to-date insurance information.
Insurance and health plan networks that the various Mount Sinai Health System hospitals and facilities participate in can be found on the Mount Sinai Health System website.
Publications
Selected Publications
- Cell Type–Specific Whole-Genome Landscape of ΔFOSB Binding in the Nucleus Accumbens After Chronic Cocaine Exposure. Szu Ying Yeh, Molly Estill, Casey K. Lardner, Caleb J. Browne, Angelica Minier-Toribio, Rita Futamura, Katherine Beach, Catherine A. McManus, Song jun Xu, Shuo Zhang, Elizabeth A. Heller, Li Shen, Eric J. Nestler. Biological Psychiatry
- Cell-Type-Specific Neuroproteomics of Synapses. Yun Young Yim, Eric J. Nestler. Biomolecules
- Transcriptional control of nucleus accumbens neuronal excitability by retinoid X receptor alpha tunes sensitivity to drug rewards. Arthur Godino, Marine Salery, Caleb J. Browne, Philipp Mews, Peter J. Hamilton, Li Shen, Scott J. Russo, Eric J. Nestler. Neuron
Industry Relationships
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.
Below are financial relationships with industry reported by Dr. Nestler during 2022 and/or 2023. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
Company Founder:
- PsychoGenics, Inc.
Consulting:
- Society of Biological Psychiatry
- PSYLO
- PsychoGenics, Inc.
- Biohaven Pharmaceuticals
Equity (Stock or stock options valued at greater than 5% ownership of a publicly traded company or equity of any value in a privately held company)
- Berg Pharma (Berg Biosystems)
- PsychoGenics, Inc.
Scientific Advisory Board:
- Berg Pharma (Berg Biosystems)
Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.