Eric J Nestler - Psychiatry | Mount Sinai

About Me

Dr. Nestler is the Nash Family Professor of Neuroscience, Director of the Friedman Brain Institute, and Dean for Academic Affairs at the Icahn School of Medicine at Mount Sinai and Chief Scientific Officer of the Mount Sinai Health System. His laboratory studies the molecular mechanisms of drug addiction and depression in animal models.

Visit Eric Nestler's Laboratory of Molecular Psychiatry and NIDA Program Project Grant for more information.

Language

English

Position

DEAN FOR ACADEMIC AFFAIRS, DIRECTOR FRIEDMAN BRAIN INSTITUTE, PROFESSOR | Neuroscience, PROFESSOR | Pharmacological Sciences, PROFESSOR | Psychiatry, CHIEF SCIENTIFIC OFFICER

Hospital Affiliations

Mount Sinai Queens
The Mount Sinai Hospital

Research Topics

Addiction, Behavioral Health, Depression, Epigenetics, Molecular Biology, Neuroscience, Stress, Synapses, Synaptic Plasticity, Synaptogenesis

Multi-Disciplinary Training Areas

Disease Mechanisms and Therapeutics (DMT), Neuroscience [NEU]

Education

MD, Yale University School of Medicine

PhD, Yale University

Internship, Psychiatry

McLean Hospital

Residency, Psychiatry

Yale University School of Medicine

Fellowship, Clinical Pharmacology

Yale University School of Medicine

Fellowship, Psychiatry

Yale University School of Medicine

Awards

2019

Redelsheimer Distinguished Research Award, Society of Biological Psychiatry

2017

Wilbur Cross Distinguished Alumnus Medal, Yale University

2017

Paul Hoch Distinguished Service Award

2010

Sarnat Prize, Institute of Medicine

2005

American Academy of Arts and Science

1998

Institute of Medicine (National Academy of Medicine)

Research

Nestler Lab, Laboratory of Molecular Psychiatry

Specific Clinical/Research Interest: Molecular neurobiology of drug addiction and depression; transcriptional and epigenetic regulation in the brain.

Our research focuses on identifying the neurobiological basis of drug addiction and depression in rodent models. We study the molecular and cellular changes that occur in regions of the brain important for reward and motivation in response to chronic administration of a drug of abuse or chronic exposure to stress. We are particularly interested in long-lasting changes that are mediated via alterations in gene expression and chromatin remodeling. The result of the research will guide future efforts toward the development of more effective treatments for addiction and depression.

Current Team

For a complete list of publications, please visit Selected Publications.

For more, please visit the Nestler Lab.

Insurance Information

Physicians who provide services at hospitals and facilities in the Mount Sinai Health System might not participate in the same health plans as those Mount Sinai hospitals and facilities (even if the physicians are employed or contracted by those hospitals or facilities).

Information regarding insurance participation and billing by this physician may be found on this page, and can also be obtained by contacting this provider directly. Because physicians insurance participation can change, the insurance information on this page may not always be up-to-date. Please contact this physician directly to obtain the most up-to-date insurance information.

Insurance and health plan networks that the various Mount Sinai Health System hospitals and facilities participate in can be found on the Mount Sinai Health System website.

Publications

Publications:738

Selected Publications

View All Publications

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.

Below are financial relationships with industry reported by Dr. Nestler during 2024 and/or 2025. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Consulting or Other Professional Services Examples include, but are not limited to, committee participation, data safety monitoring board (DSMB) membership

Sparian Biosciences
Ellipsis Health
BPGbio
PSYLO
PsychoGenics, Inc.
EpiVario

Equity (Stock or stock options valued at greater than 5% ownership of a publicly traded company or equity of any value in a privately held company)

BPGbio
PsychoGenics, Inc.

Founder/Co-Founder/Partner

PsychoGenics, Inc.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.

Eric J Nestler, MD, PhD

Psychiatry

About Me

Language

Position

Hospital Affiliations

Research Topics

Multi-Disciplinary Training Areas

About Me

Language

Position

Hospital Affiliations

Research Topics

Multi-Disciplinary Training Areas

Video

Education

MD, Yale University School of Medicine

PhD, Yale University

Internship, Psychiatry

Residency, Psychiatry

Fellowship, Clinical Pharmacology

Fellowship, Psychiatry

Awards

Research

Insurance Information

Publications

Selected Publications

Industry Relationships