
Eric Schadt, PhD
About Me
Eric Schadt, PhD, is Dean for Precision Medicine, Professor of Genetics and Genomic Sciences, and Mount Sinai Professor in Predictive Health and Computational Biology. He is also founder and CEO of Sema4, a Mount Sinai Venture
Dr. Schadt is an expert on the generation and integration of very large-scale sequence variation, molecular profiling and clinical data in disease populations for constructing molecular networks that define disease states and link molecular biology to physiology. He is known for calling for a shift in molecular biology toward a network-oriented view of living systems to complement the reductionist, single-gene approaches that currently dominate biology in order to more accurately model the complexity of biological systems. He has published more than 200 peer-reviewed papers in leading scientific journals, and contributed to a number of discoveries relating to the genetic basis of common human diseases such as diabetes, obesity, and Alzheimer’s disease.
Prior to joining Mount Sinai in 2011, he was Chief Scientific Officer at Pacific Biosciences. Previously, Dr. Schadt was Executive Scientific Director of Genetics at Rosetta Inpharmatics, a subsidiary of Merck & Co., and before Rosetta, Dr. Schadt was a Senior Research Scientist at Roche Bioscience. He received his B.A. in applied mathematics and computer science from California Polytechnic State University, his M.A. in pure mathematics from University of California, Davis, and his Ph.D. in bio-mathematics from University of California, Los Angeles (requiring Ph.D. candidacy in molecular biology and mathematics).
Language
English
Position
DEAN FOR PRECISION MEDICINE, PROFESSOR | Artificial Intelligence and Human Health, PROFESSOR | Genetics and Genomic Sciences
Research Topics
Bioinformatics, Computational Neuroscience, Epigenetics, Genetics, Human Genetics and Genetic Disorders
Video
Publications
Selected Publications
- Establishing the relationship between brain cellular senescence and brain structure. Anina N. Lund, Brian H. Kopell, Negar Golestani, Eric Vornholt, Ryan C. Thompson, Lora E. Liharska, Yuyang Luo, Esther Cheng, You Jeong Park, Brian Fennessy, Lilian Wilkins, Deepak A. Kaji, Hannah Silk, Kimia Ziafat, Alice Hashemi, Emily Moya, Claudia Feng, Lisa M. Linares, Ariela Buxbaum Grice, Sabrina Xie, Marysia Kolbe Rieder, Joseph Scarpa, Prashant Kota, Vanessa Cohen, Brendan Sullivan, Punit Shah, Weiping Ma, Jessica S. Johnson, Gregory M. Miller, Richard Searfoss, Nischal Mahaveer Chand, Pei Wang, Girish N. Nadkarni, Niven R. Narain, Eric J. Nestler, Michael A. Kiebish, Eric E. Schadt, Alexander W. Charney, Noam D. Beckmann. Cell
- A Collection of Patient-Derived Intestinal Organoid Lines Reveals Epithelial Phenotypes Associated with Genetic Drivers of Pediatric Inflammatory Bowel Disease. Zahra Shojaei Jeshvaghani, Carmen Argmann, Maaike H. De Vries, Johan H. Van Es, Lauren V. Collen, Daniel Kotlarz, Mia Sveen, Phillip H. Comella, Scott B. Snapper, Christoph Klein, Eric E. Schadt, Hans Clevers, Michal Mokry, Ewart Kuijk, Edward Nieuwenhuis. Inflammatory Bowel Diseases
- A study of gene expression in the living human brain. Lora E. Liharska, You Jeong Park, Kimia Ziafat, Lillian Wilkins, Hannah Silk, Lisa M. Linares, Ryan C. Thompson, Eric Vornholt, Brendan Sullivan, Vanessa Cohen, Prashant Kota, Claudia Feng, Esther Cheng, Jessica S. Johnson, Marysia Kolbe Rieder, Jia Huang, Joseph Scarpa, Jairo Polanco, Emily Moya, Alice Hashemi, Matthew A. Levin, Girish N. Nadkarni, Robert Sebra, John F. Crary, Eric E. Schadt, Noam D. Beckmann, Brian H. Kopell, Alexander W. Charney. Molecular Psychiatry