
Eric Schadt, PhD
About Me
Eric Schadt, PhD, is Dean for Precision Medicine, Professor of Genetics and Genomic Sciences, and Mount Sinai Professor in Predictive Health and Computational Biology. He is also founder and CEO of Sema4, a Mount Sinai Venture
Dr. Schadt is an expert on the generation and integration of very large-scale sequence variation, molecular profiling and clinical data in disease populations for constructing molecular networks that define disease states and link molecular biology to physiology. He is known for calling for a shift in molecular biology toward a network-oriented view of living systems to complement the reductionist, single-gene approaches that currently dominate biology in order to more accurately model the complexity of biological systems. He has published more than 200 peer-reviewed papers in leading scientific journals, and contributed to a number of discoveries relating to the genetic basis of common human diseases such as diabetes, obesity, and Alzheimer’s disease.
Prior to joining Mount Sinai in 2011, he was Chief Scientific Officer at Pacific Biosciences. Previously, Dr. Schadt was Executive Scientific Director of Genetics at Rosetta Inpharmatics, a subsidiary of Merck & Co., and before Rosetta, Dr. Schadt was a Senior Research Scientist at Roche Bioscience. He received his B.A. in applied mathematics and computer science from California Polytechnic State University, his M.A. in pure mathematics from University of California, Davis, and his Ph.D. in bio-mathematics from University of California, Los Angeles (requiring Ph.D. candidacy in molecular biology and mathematics).
Language
English
Position
DEAN FOR PRECISION MEDICINE, PROFESSOR | Artificial Intelligence and Human Health, PROFESSOR | Genetics and Genomic Sciences
Research Topics
Bioinformatics, Computational Neuroscience, Epigenetics, Genetics, Human Genetics and Genetic Disorders
Video
Publications
Selected Publications
- Proteomic-based stemness score measures oncogenic dedifferentiation and enables the identification of druggable targets. Iga Kołodziejczak-Guglas, Renan L.S. Simões, Emerson de Souza Santos, Elizabeth G. Demicco, Rossana N. Lazcano Segura, Weiping Ma, Pei Wang, Yifat Geffen, Erik Storrs, Francesca Petralia, Antonio Colaprico, Felipe da Veiga Leprevost, Pietro Pugliese, Michele Ceccarelli, Houtan Noushmehr, Alexey I. Nesvizhskii, Bożena Kamińska, Waldemar Priebe, Jan Lubiński, Bing Zhang, Alexander J. Lazar, Paweł Kurzawa, Mehdi Mesri, Ana I. Robles, Alicia Francis, Amanda G. Paulovich, Anna P. Calinawan, Antonio Iavarone, Arul M. Chinnaiyan, Bo Wen, Boris Reva, Brian J. Druker, Caleb M. Lindgren, Chandan Kumar-Sinha, Chelsea J. Newton, Chen Huang, Chet Birger, Corbin Day, D. R. Mani, Daniel Cui Zhou, Daniel W. Chan, David Fenyö, David I. Heiman, Dmitry Rykunov, Emily Huntsman, Eric E. Schadt, Eric J. Jaehnig, Shrabanti Chowdhury, Xiaoyu Song, Zeynep H. Gümüş. Cell Genomics
- PGV001, a Multi-Peptide Personalized Neoantigen Vaccine Platform: Phase I Study in Patients with Solid and Hematologic Malignancies in the Adjuvant Setting. Mansi Saxena, Thomas U. Marron, Julia Kodysh, John P. Finnigan, Sayali Onkar, Anna Kaminska, Kevin Tuballes, Ruiwei Guo, Rachel Lubong Sabado, Marcia Meseck, Timothy J. O’donnell, Robert P. Sebra, Samir Parekh, Matthew D. Galsky, Ana Blasquez, Gustavo Gimenez, Mesude Bicak, Cansu Cimen Bozkus, Daniela Delbeau-Zagelbaum, Denise Rodriguez, Ana Acuna-Villaorduna, Krzysztof J. Misiukiewicz, Marshall R. Posner, Brett A. Miles, Hanna Y. Irie, Amy Tiersten, Deborah B. Doroshow, Andrea Wolf, John Mandeli, Rachel Brody, Andres M. Salazar, Sacha Gnjatic, Jeff Hammerbacher, Eric Schadt, Philip Friedlander, Alexander Rubinsteyn, Nina Bhardwaj. Cancer Discovery
- Precision proteogenomics reveals pan-cancer impact of germline variants. Fernanda Martins Rodrigues, Nadezhda V. Terekhanova, Kathleen J. Imbach, Karl R. Clauser, Myvizhi Esai Selvan, Isabel Mendizabal, Yifat Geffen, Yo Akiyama, Myranda Maynard, Tomer M. Yaron, Yize Li, Song Cao, Erik P. Storrs, Olivia S. Gonda, Adrian Gaite-Reguero, Akshay Govindan, Emily A. Kawaler, Matthew A. Wyczalkowski, Robert J. Klein, Berk Turhan, Karsten Krug, D. R. Mani, Felipe da Veiga Leprevost, Alexey I. Nesvizhskii, Steven A. Carr, David Fenyö, Michael A. Gillette, Antonio Colaprico, Antonio Iavarone, Ana I. Robles, Kuan lin Huang, Chandan Kumar-Sinha, François Aguet, Alexander J. Lazar, Lewis C. Cantley, Urko M. Marigorta, Zeynep H. Gümüş, Matthew H. Bailey, Gad Getz, Eduard Porta-Pardo, Li Ding, Eunkyung An, Meenakshi Anurag, Jasmin Bavarva, Shrabanti Chowdhury, Francesca Petralia, Boris Reva, Eric E. Schadt, Xiaoyu Song, Pei Wang. Cell