Ernesto Guccione, PhD
During my PhD at the International Center for Genetic Engineering Biotechnology (ICGEB) I have studied the oncogenic functions of HPV E6/E7 viral proteins and the relevance of splicing in regulating E6 functions. My postdoctoral work at the European Institute of Oncology I studied the role of chromatin in defining c-MYC target site recognition. I have also identified PRMT6, a member of the Protein Arginine MethylTransferase (PRMT) family, as an important enzyme regulating transcriptional repression.
In 2008 I started my lab at A*STAR in Singapore where I was promoted to Research Director and Coordinated the program of Epigenetics and Diseases.
In 2019 I moved to the department of Oncological Sciences and Pharmacological Sciences at Icahn School of Medicine at Mount Sinai where I am currently an Associate Professor.
My lab has a long-standing interest in understanding basic mechanisms of transcriptional and post-transcriptional regulation in order to identify therapeutic opportunities in oncology.
Currently, we are interested in the function in development and disease of Protein MethylTrasnferases (PMTs) and in modulation of Alternative Splicing using Splice switching Antisense Oligonucleotide (AON)-based approaches.
Lab Website: Guccione Lab
Cancer, Developmental Biology, Epigenetics, Post-Transcriptional Processing
Multi-Disciplinary Training Areas
Cancer Biology [CAB], Development Regeneration and Stem Cells [DRS]