Publications:238
Filip Swirski, PhD
About Me
Dr. Swirski obtained his PhD at McMaster University in Canada and postdoctoral studies at Brigham and Women’s Hospital. Dr. Swirski was Professor at Harvard Medical School and Massachusetts General Hospital before joining Mount Sinai in 2021. Dr. Swirski’s research focuses on innate immunity and inflammation in cardiovascular disease. He uses in vivo models of acute and chronic inflammation relevant to cardiovascular and metabolic diseases, with specific emphasis on cell development, communication, and function. Recently, his focus has expanded to include lifestyle factors such as sleep, diet, and stress as critical modulators of cardiovascular health and hematopoiesis.
Language
English
Position
PROFESSOR | Medicine, Cardiology, PROFESSOR | Diagnostic, Molecular and Interventional Radiology, PROFESSOR | Immunology & Immunotherapy
Research Topics
Alzheimer's Disease, Autoimmunity, B Cells, Blood, Brain, Cardiac Arrest and Resuscitation, Cardiovascular, Cellular Immunity, Chemokines, Chemotaxis, Cytokines, Dendritic Cells, Endocrinology, Hematopoiesis, Immunology, Inflammation, Lung, Lymphocytes, Macrophage, Microglia, Pathology, Sleep Medicine, Stem Cells, Stress, Systems Biology, T Cells, Transgenic Mice, Viruses and Virology
Multi-Disciplinary Training Areas
Immunology [IMM], Microbiology [MIC], Neuroscience [NEU]
Education
PhD, McMaster University
, Harvard Medical School
Awards
2020
ESC William Harvey Lecture on Basic Science
European Society of Cardiology
2019
Tucker Collins Lecture
2018
Leaders in Cardiovascular Science Profile
Circulation Research
2017
Jeffrey M Hoeg Award for Basic Science and Clinical Research
2017
Established Investigator Award
AHA
2016
Patricia and Scott Eston MGH Research Scholar
2016
Martin Prize for Fundamental Research
2016
Outstanding Investigator Award
NIH
2005
Howard M. Goodman Fellowship
Research
A major long-standing focus is to understand how monocytes and macrophages participate in atherosclerosis and myocardial infarction. I showed that monocytes accumulate continuously in evolving atherosclerotic lesions. I linked atherosclerosis with blood monocytosis. I identified a biphasic monocyte-macrophage response that coordinates healing, and discovered a monocyte reservoir in the spleen. I showed that sleep protects against atherosclerosis by limiting monocyte production.
Publications
Selected Publications
- Modeling the Exposome in Murine Cardiovascular Disease. Bibi Alika Sulaman, Jing Zhu, Ting Xiong, Taylor E. Ireland, Jeffrey Downey, Filip K. Swirski, Clinton S. Robbins, Nicholas J. Leeper, Wolfram C. Poller, Cameron S. McAlpine. JACC: Basic to Translational Science
- Spatially Distinct Bone Marrow Sites Are Asymmetrically Impacted by Inflammatory Cardiovascular Disease. Jeroen Deckers, Yuri van Elsas, Iris Versteeg, Tom Anbergen, Yohana C. Toner, Cristina Grao-Roldán, Jennifer E. Cole, Martin Umali, William Wang, Sheqouia Nauta, Krystyna M. Demkiw, Carlos Pérez-Medina, Mandy M.T. van Leent, Abraham J.P. Teunissen, Zahi A. Fayad, Leo A.B. Joosten, Filip K. Swirski, Matthias Nahrendorf, Maziar Divangahi, Niels P. Riksen, Mihai G. Netea, Roy van der Meel, Claudia Monaco, Esther Lutgens, Thijs J. Beldman, Willem J.M. Mulder. JACC: Basic to Translational Science
- Splenic regulation of systemic platelet activation state. Lisa Laun, Alexander Leunig, Felix Zhang, Sezer Akgöl, Dario Rossaro, Matthias P. Fabritius, Afra Anjum, Lennart Kreutz, Nathalie Mackert, Gabriel H.M. Araujo, Shaan Mahameed, Craig Balmforth, Marie Louise Hoffknecht, Magdalena Mader, Konstantin Hoffmann, Justus Reittinger, Johanna Knechtel, Nellie M. Kwabla, Maité Mulkers, Michael Schmid, Jean Solarz, Hannah Niederdorfer, Raphael Escaig, Robin Dewender, Heiko Schulz, Frederick Klauschen, Konstantin Stark, Florian Gaertner, David E. Newby, Bernhard Nieswandt, Filip K. Swirski, Zoltan Nagy, Alexandra Mazharian, Rainer Kaiser, Yotis A. Senis, Steffen Massberg, Leo Nicolai. Science (New York, N.Y.)
Industry Relationships
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.
Dr. Swirski has not yet completed reporting of industry relationships or has no industry relationships to report.
Mount Sinai’s faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.