Publications:222
Filip Swirski, PhD
About Me
Dr. Swirski obtained his PhD at McMaster University in Canada and postdoctoral studies at Brigham and Women’s Hospital. Dr. Swirski was Professor at Harvard Medical School and Massachusetts General Hospital before joining Mount Sinai in 2021. Dr. Swirski’s research focuses on innate immunity and inflammation in cardiovascular disease. He uses in vivo models of acute and chronic inflammation relevant to cardiovascular and metabolic diseases, with specific emphasis on cell development, communication, and function. Recently, his focus has expanded to include lifestyle factors such as sleep, diet, and stress as critical modulators of cardiovascular health and hematopoiesis.
Language
English
Position
PROFESSOR | Medicine, Cardiology, PROFESSOR | Diagnostic, Molecular and Interventional Radiology, PROFESSOR | Immunology & Immunotherapy
Research Topics
Alzheimer's Disease, Autoimmunity, B Cells, Blood, Brain, Cardiac Arrest and Resuscitation, Cardiovascular, Cellular Immunity, Chemokines, Chemotaxis, Cytokines, Dendritic Cells, Endocrinology, Hematopoiesis, Immunology, Inflammation, Lung, Lymphocytes, Macrophage, Microglia, Pathology, Sleep Medicine, Stem Cells, Stress, Systems Biology, T Cells, Transgenic Mice, Viruses and Virology
Multi-Disciplinary Training Areas
Immunology [IMM], Microbiology [MIC], Neuroscience [NEU]
Education
PhD, McMaster University
, Harvard Medical School
Awards
2020
ESC William Harvey Lecture on Basic Science
European Society of Cardiology
2019
Tucker Collins Lecture
2018
Leaders in Cardiovascular Science Profile
Circulation Research
2017
Jeffrey M Hoeg Award for Basic Science and Clinical Research
2017
Established Investigator Award
AHA
2016
Patricia and Scott Eston MGH Research Scholar
2016
Martin Prize for Fundamental Research
2016
Outstanding Investigator Award
NIH
2005
Howard M. Goodman Fellowship
Research
A major long-standing focus is to understand how monocytes and macrophages participate in atherosclerosis and myocardial infarction. I showed that monocytes accumulate continuously in evolving atherosclerotic lesions. I linked atherosclerosis with blood monocytosis. I identified a biphasic monocyte-macrophage response that coordinates healing, and discovered a monocyte reservoir in the spleen. I showed that sleep protects against atherosclerosis by limiting monocyte production.
Publications
Selected Publications
- Myelopoiesis is temporally dynamic and is regulated by lifestyle to modify multiple sclerosis. Abi G. Yates, Annie Khamhoung, Lena Gaebel, Walter Jacob, Daniel E. Radford-Smith, Máté G. Kiss, Pacific Huynh, Teresa Gerhardt, Merlin Heiser, Oren Cohen, Filip K. Swirski, Daniel C. Anthony, James Sumowski, Ilana Katz Sand, Cameron S. McAlpine. Nature Communications
- Neural Mechanisms in Cardiovascular Health and Disease. Karin A. Ziegler, Stefan Engelhardt, Daniela Carnevale, Cameron S. McAlpine, Tomasz J. Guzik, Stefanie Dimmeler, Filip K. Swirski. Circulation Research
- Novel Artificial 5′UTR Increase Modified mRNA Translation When Injected into Mouse Heart. Ann Anu Kurian, Matteo Ghiringhelli, Eyal Shalom, Gayatri Mainkar, Magdalena M. Żak, Matthew Adjmi, Jeffrey Downey, Seonghun Yoon, Nicole Dubois, Filip K. Swirski, Lior Zangi. Pharmaceutics