Publications:232
Filip Swirski, PhD
About Me
Dr. Swirski obtained his PhD at McMaster University in Canada and postdoctoral studies at Brigham and Women’s Hospital. Dr. Swirski was Professor at Harvard Medical School and Massachusetts General Hospital before joining Mount Sinai in 2021. Dr. Swirski’s research focuses on innate immunity and inflammation in cardiovascular disease. He uses in vivo models of acute and chronic inflammation relevant to cardiovascular and metabolic diseases, with specific emphasis on cell development, communication, and function. Recently, his focus has expanded to include lifestyle factors such as sleep, diet, and stress as critical modulators of cardiovascular health and hematopoiesis.
Language
English
Position
PROFESSOR | Medicine, Cardiology, PROFESSOR | Diagnostic, Molecular and Interventional Radiology, PROFESSOR | Immunology & Immunotherapy
Research Topics
Alzheimer's Disease, Autoimmunity, B Cells, Blood, Brain, Cardiac Arrest and Resuscitation, Cardiovascular, Cellular Immunity, Chemokines, Chemotaxis, Cytokines, Dendritic Cells, Endocrinology, Hematopoiesis, Immunology, Inflammation, Lung, Lymphocytes, Macrophage, Microglia, Pathology, Sleep Medicine, Stem Cells, Stress, Systems Biology, T Cells, Transgenic Mice, Viruses and Virology
Multi-Disciplinary Training Areas
Immunology [IMM], Microbiology [MIC], Neuroscience [NEU]
Education
PhD, McMaster University
, Harvard Medical School
Awards
2020
ESC William Harvey Lecture on Basic Science
European Society of Cardiology
2019
Tucker Collins Lecture
2018
Leaders in Cardiovascular Science Profile
Circulation Research
2017
Jeffrey M Hoeg Award for Basic Science and Clinical Research
2017
Established Investigator Award
AHA
2016
Patricia and Scott Eston MGH Research Scholar
2016
Martin Prize for Fundamental Research
2016
Outstanding Investigator Award
NIH
2005
Howard M. Goodman Fellowship
Research
Systemic inflammatory networks connect various cardiovascular and metabolic processes. I showed that the spleen produces monocytes by extramedullary hematopoiesis. I provided evidence for the relative contribution of monocyte recruitment and macrophage proliferation atherosclerosis. I identified an on-demand mechanism by which transient monocyte-derived macrophages dispose of erythrocytes and recycle iron. I identified a population of intraepithelial T cells that modulate dietary metabolism and contribute to cardiovascular disease.
Publications
Selected Publications
- A tumor-selective mRNA system enables precision cancer treatment. Magdalena M. Żak, Jimeen Yoo, Alberto Utrero-Rico, Wencke Walter, Gayatri Mainkar, Matthew Adjmi, Ann Anu Kurian, Ashikur Rahaman, Daniel Lozano Ojalvo, Jordi Ochando, Torsten Haferlach, Ramon E. Parsons, Filip K. Swirski, Lior Zangi. Molecular Therapy
- Sleep and circadian rhythms in cardiovascular resilience: mechanisms, implications, and a Roadmap for research and interventions. Brooke Aggarwal, Yunling Gao, Alfonso Alfini, Ali Azarbarzin, Ron C. Anafi, Kelly Glazer Baron, Victoria L. Bautch, Nicole Bowles, Josiane L. Broussard, Marishka Brown, Philip Cheng, Stephanie H. Cook, Rene Cortese, Fabian Xosé Fernandez, Zorina Galis, Dayna A. Johnson, Sanja Jelic, Jonathan O. Lipton, Pamela L. Lutsey, Qing Miao, Jose M. Ordovas, Aric A. Prather, Filip K. Swirski, Esra Tasali, Ivan Vargas, Michael A. Grandner, Donald Lloyd-Jones. Nature Reviews Cardiology
- Connection and communication between the nervous and immune systems. Alexander Leunig, Matteo Gianeselli, Scott J. Russo, Filip K. Swirski. Nature Reviews Immunology