Greg Holmes, PhD
Greg Holmes received his PhD from The University of Queensland, Australia. In the laboratory of Melissa Little, he characterized protein-DNA and protein-protein interactions of the Wilms’ tumor suppressor gene 1 (WT1) zinc-finger protein and the effect of Denys-Drash syndrome mutations on WT1 DNA binding. His postdoctoral training has been in the laboratories of Lee Niswander (Memorial Sloan-Kettering Cancer Center, NY) studying chick and mouse embryological limb development, and Claudio Basilico (NYU School of Medicine, NY) studying inhibitory interactions of the Fgf signaling pathway on the Wnt signaling pathway in osteoblasts. While there, he developed a strong interest in craniofacial development, studying a mouse model of the Apert craniosynostosis syndrome. He joined the laboratory of Ethylin Wang Jabs at Mount Sinai as an Instructor in 2011 to pursue further research into the molecular processes and tissue interactions underlying a variety of craniosynostosis syndromes. He is currently an Assistant Professor in the Department of Genetics and Genomic Sciences. Current projects are based on developing expression maps of murine craniofacial sutures during embryonic and postnatal development, through the integration of laser capture microdissection-derived bulk RNA-Seq and single cell RNA-Seq approaches. The goal is to understand suture development within the calvaria and face/palate by identifying and investigating the role of novel genes and cell subpopulations within sutures. This will enhance our understanding of disease mechanisms in craniofacial development and our ability to ameliorate or prevent these conditions.
Bone Biology, Cartilage Biology, Developmental Biology, Embryology, Molecular Biology, Morphogenesis, Skeletal Biology