Ian S Maze, PhD

The Maze laboratory is focused on understanding the role of chromatin dynamics, nucleosomal turnover and histone modifications in the central nervous system during periods of transcriptional, synaptic and behavioral plasticity. Extended emphasis is placed on investigating the functions of novel neuronal specific/enriched histone modifications and ‘reader’ proteins, as well as their role in developmental neurological disorders (e.g. Down syndrome, autism) and adult psychiatric illness (major depressive disorder, substance use disorder, etc.). Current projects include the utilization of chromatin biochemical techniques, genome-wide sequencing analyses and transgenic/viral vector-based gene modification systems to investigate novel chromatin-based mechanisms of monoaminergic dysfunction in disease.  Search PubMed for publications