Ian S Maze | Mount Sinai

About Me

Ian S. Maze, Ph.D., is a chromatin biologist and neuroscientist investigating the complex interplay between chromatin regulatory mechanisms and neural plasticity in the mammalian central nervous system. His multidisciplinary and integrative research involves the use of biochemical, biophysical, physiological and behavioral analyses to explore the molecular underpinnings of neurodevelopmental and adult cognitive and psychiatric disorders. Dr. Maze is actively investigating the brains of rodents and postmortem humans, as well as human iPSC-derived neurons, to uncover chromatin-based mechanisms of neurological disease.

Language

English

Position

PROFESSOR | Neuroscience, PROFESSOR | Pharmacological Sciences

Research Topics

Addiction, Behavior, Chromatin, Depression, Drug Design and Discovery, Gene Expressions, Molecular Biology, Neuroscience

Multi-Disciplinary Training Areas

Disease Mechanisms and Therapeutics (DMT), Neuroscience [NEU]

About Me

Ian S. Maze, Ph.D., is a chromatin biologist and neuroscientist investigating the complex interplay between chromatin regulatory mechanisms and neural plasticity in the mammalian central nervous system. His multidisciplinary and integrative research involves the use of biochemical, biophysical, physiological and behavioral analyses to explore the molecular underpinnings of neurodevelopmental and adult cognitive and psychiatric disorders. Dr. Maze is actively investigating the brains of rodents and postmortem humans, as well as human iPSC-derived neurons, to uncover chromatin-based mechanisms of neurological disease.

Language

English

Position

PROFESSOR | Neuroscience, PROFESSOR | Pharmacological Sciences

Research Topics

Addiction, Behavior, Chromatin, Depression, Drug Design and Discovery, Gene Expressions, Molecular Biology, Neuroscience

Multi-Disciplinary Training Areas

Disease Mechanisms and Therapeutics (DMT), Neuroscience [NEU]

Education

BS, The Ohio State University

PhD, Mount Sinai School of Medicine

Postdoctoral Fellowship, The Rockefeller University

Awards

2022

McKnight Brain Disorder Award

2021

Howard Hughes Medical Institute Investigator

2019

Dr. Harold and Golden Laport Basic Research Award

2019

Winner of Presidential Early Career Award for Scientists and Engineers (PECASE)

2017

Basil O’Connor Award

March of Dimes

2016

Sloan Foundation Fellowship in Neuroscience

2015

ACNP Travel Award

2015

MQ: Transforming Mental Health Research Fellowship Award

2014

NARSAD Young Investigator Award

2011

Terry A. Krulwich Dissertation Award, Mount Sinai School of Medicine

Research

The Maze laboratory is focused on understanding the role of chromatin dynamics, nucleosomal turnover and histone modifications in the central nervous system during periods of transcriptional, synaptic and behavioral plasticity. Extended emphasis is placed on investigating the functions of novel neuronal specific/enriched histone modifications and ‘reader’ proteins, as well as their role in developmental neurological disorders (e.g. Down syndrome, autism) and adult psychiatric illness (major depressive disorder, substance use disorder, etc.). Current projects include the utilization of chromatin biochemical techniques, genome-wide sequencing analyses and transgenic/viral vector-based gene modification systems to investigate novel chromatin-based mechanisms of monoaminergic dysfunction in disease. Search PubMed for publications