Jaroslav Bendl, PhD
About Me
Jaroslav Bendl, PhD, is an Assistant Professor of Psychiatry and Genetics and Genomic Sciences at the Icahn School of Medicine at Mount Sinai and a principal investigator within the Center for Disease Neurogenomics. He leads an independent computational neurogenomics research program investigating how genetic variation and cell-type-specific molecular regulation contribute to vulnerability and resilience in neuropsychiatric and neurodegenerative disorders.
Dr. Bendl’s research integrates statistical genetics with single-cell and spatial transcriptomics, epigenomics, and long-read sequencing in large human postmortem cohorts. His work focuses particularly on Alzheimer’s disease, Parkinson’s disease, schizophrenia, and bipolar disorder, with the goal of connecting genetic risk variants to molecular mechanisms in specific cell types and brain regions. His research program also develops computational methods and openly available data resources for analyzing and sharing population-scale human multi-omic datasets.
Dr. Bendl is the principal investigator of an NIH/NINDS R01, “Mapping the Epigenomic and Spatial Transcriptomic Landscape in Parkinson’s Disease.” In the past, he received independent funding from the Alzheimer’s Association and the Brain & Behavior Research Foundation. Through initiatives including PsychENCODE, AMP-AD, AMP-PD, and the CommonMind Consortium, he has led computational analyses of some of the largest single-cell transcriptomic and epigenomic datasets generated from the human brain.
Dr. Bendl received his PhD in Computer Science from Brno University of Technology in 2016. Before focusing on human neurogenomics, he developed computational tools for interpreting genetic variants and engineering proteins, including PredictSNP, FireProt, and HotSpot Wizard. His current work spans computational-method development, generation of large-scale molecular atlases, and mechanistic studies designed to translate human genomic discoveries into experimentally testable models of brain disease.
Language
English
Position
ASSISTANT PROFESSOR | Psychiatry, ASSISTANT PROFESSOR | Genetics and Genomic Sciences
Industry Relationships
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.
Dr. Bendl has not yet completed reporting of industry relationships or has no industry relationships to report.
Mount Sinai’s faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.