Jaymin Kathiriya, PhD

About Me

Jaymin Kathiriya, Ph.D., is an Assistant Professor in the Departments of Medicine and Cell, Developmental, and Regenerative Biology at the Icahn School of Medicine at mount Sinai. He is a member of the Black Family Stem Cell Institute, Institute for Airway Science, and Mount Sinai Respiratory Institute. His research interests focus on understanding the signaling pathways and cellular remodeling that affect fate decisions of distal lung epithelial stem cells. He obtained his PhD at University of South Florida where he identified gene regulatory networks underpinning hypoxia signaling in profibrotic activation of lung epithelium. During his postdoctoral training under Hal Chapman at University of California, San Francisco, he discovered key stem/progenitor cell populations in mouse and human distal lung epithelium that are responsible for both normal and abnormal injury response. Of note, his work discovered previously unappreciated transdifferentiation capacity of human type 2 alveolar epithelial cells to give rise to metaplastic basal cells often observed in the lungs of patients with Idiopathic Pulmonary Fibrosis. The Kathiriya lab uses in vitro, in vivo, and in silico computational tools and techniques to study early mechanisms of stem cell activation and role of cytoskeletal remodeling in abnormal differentiation of stem cells in diseases.

Lab Website:

http://labs.icahn.mssm.edu/kathiriyalab/

Language

English

Position

ASSISTANT PROFESSOR | Medicine, Pulmonary, Critical Care and Sleep Medicine, ASSISTANT PROFESSOR | Stem Cell Biology And Regenerative Medicine

Research Topics

Cellular Differentiation, Computational Biology, Developmental Biology, Epigenetics, Epithelial Cells, Gene Expressions, Gene Regulation, Gene editing, Genetics, Genomics, Lung, Organogenesis, Regeneration, Respiratory, Stem Cells, Transcription Factors, Transgenic Mice

Multi-Disciplinary Training Areas

Development Regeneration and Stem Cells [DRS]

Education

BS, University of California, Davis

MS, University of California, Irvine

PhD, University of South Florida

Research

The Kathiriya Lab focuses on studying how fate decisions of distal lung epithelial stem cells are affected by intrinsic and extrinsic factors. Upon injury, dedicated adult stem/progenitor cells are preferentially activated to locally regenerate injured regions of the distal lung. Subsequently, the microenvironment and surrounding cell types influence cytoskeletal remodeling of differentiating stem cells, often causing maladaptive differentiation during disease progression. The Kathiriya lab aims to investigate what makes the stem cells respond preferentially upon injury and the mechanisms affecting the cytoskeletal remodeling of distal lung epithelial stem cells to cause abnormal regeneration, resulting in disease state. The overall aim of the lab is to create therapeutic interventions that can help stem cells regenerate functional alveoli. To achieve this goal, the Kathiriya Lab integrates in vitro 3D stem cell organoids, in vivo mouse genetics, and in silico computational data modeling.

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.

Dr. Kathiriya has not yet completed reporting of Industry relationships.

Mount Sinai’s faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.