
Jerry Chipuk, PhD
Jerry Edward Chipuk (Preferred Name)
About Me
Jerry Edward Chipuk, PhD, is Professor of Oncological Sciences and Dermatology, Associate Director of Shared Resources at the Mount Sinai Tisch Cancer Center, and Director for Cell Biology in the Graduate School of Biomedical Sciences at the Icahn School of Medicine at Mount Sinai. He joined Mount Sinai in 2010, following post-doctoral fellowships at St. Jude Children’s Research Hospital in Memphis and La Jolla Institute for Allergy and Immunology in San Diego.
Dr. Chipuk studies fundamental mitochondrial biology within the perspective of human disease etiology and treatment. His laboratory has developed multiple model systems, collaborations, and experimental tools to investigate the intersections between mitochondria, cell biology, and disease.
As Associate Director of Shared Resources, Dr. Chipuk supports Bioinformatics for Next Generation Sequencing, Biorepository, Biostatistics, Cancer Genomics Technologies, Flow Cytometry, Microscopy, and Human Immune Monitoring Center resources within the cancer community, and he develops new core resources for the Mount Sinai Tisch Cancer Center. Dr. Chipuk is a member of both the Mount Sinai Tisch Cancer Center and the Diabetes, Obesity, & Metabolism Institute. He is also the founding Director of the Mitochondrial Analysis Facility.
Dr. Chipuk is an associate editor for numerous journals focused on molecular and cellular biology. He also serves on the Board of Directors of the International Cell Death Society, is a Senior Affiliate with bioRšiv, a preprint server for biology operated by the Cold Spring Harbor Laboratory, and is a member of numerous committees of the American Society for Cell Biology.
Language
English
Position
PROFESSOR | Oncological Sciences, PROFESSOR | Dermatology, PROFESSOR | Graduate Education
Research Topics
Anti-Tumor Therapy, Apoptosis/Cell Death, Cancer, Cell Biology, Cell Transformation, Drug Resistance, Imaging, Lipid Signaling, Membrane Proteins/Channels, Membranes, Mitochondria, Molecular Biology, Oncogenes, Protein Kinases, Signal Transduction, Tumor Suppressor Genes, Tumorigenesis
Multi-Disciplinary Training Areas
Cancer Biology [CAB]
Education
BS, Baldwin-Wallace College
PhD, Case Western Reserve University
Postdoctoral Training, La Jolla Institute for Allergy and Immunology
Postdoctoral Training, St. Jude Childrenās Research Hospital
Awards
2016
Career Development Award
Leukemia & Lymphoma Society
2015
Research Scholar Grant
American Cancer Society
2015
Research Award
Irma T. Hirschl / Monique Weill-Caulier Research Trusts
2014
Dr. Harold and Golden Lamport Research Award
2013
Basil O'Connor Phase-In Award
March of Dimes
2012
Young Scientist Cancer Research Fund
JJR Foundation
2011
Basil O'Connor Award
March of Dimes
2003
Ruth Kirschstein NRSA
National Institutes of Health
Research
Our current research interests are divided into three areas, but adopt a unified theme to decipher the interplay between mitochondria and cell death signaling:
I. What are the biochemical, physiological, and structural consequences of proteinĀ·protein interactions within the BCL-2 family?
II. How does the mitochondrial environment influence BCL-2 family function and the core cell death machinery?
III. How do oncogenic and tumor suppressor signals intersect with the mitochondrial dynamics machinery to regulate tumorigenesis and chemosensitivity?
We explore the above questions using state-of-the-art apoptosis, metabolism, and cancer biology model systems --- usually focusing on hematological malignancies and melanoma.
Visit the Chipuk Laboratory
Publications
Selected Publications
- Ontogeny Dictates Oncogenic Potential, Lineage Hierarchy, and Therapy Response in Pediatric Leukemia. Ke Wang, Shayan Saniei, Nikita Poddar, Isabella G. Martinez, Clifford Chao, Subrina Autar, Persephone Fiore, Saul Carcamo, Meghana Sreenath, Jack H. Peplinski, Rhonda E. Ries, Anna Huo Chang Mei, Noshin Azra Rahman, Levan Mekerishvili, Miguel Quijada-Ćlamo, Grace Freed, Mimi Zhang, Katherine Lachman, Zayna Diaz, Manuel M. Gonzalez, Jing Zhang, Giang Pham, Dan Filipescu, Mirela Berisa, Tommaso Balestra, Noelle Wheeler, Julie A. Reisz, Angelo D'Alessandro, Daniel J. Puleston, Emily Bernstein, Jerry E. Chipuk, Mark Wunderlich, Sarah K. Tasian, Bridget K. Marcellino, Ian A. Glass, Christopher M. Sturgeon, Dan A. Landau, Zhihong Chen, Eirini P. Papapetrou, Franco Izzo, Soheil Meshinchi, Dan Hasson, Elvin Wagenblast. Cancer Discovery
- Metabolic adaptations to acute glucose uptake inhibition converge upon mitochondrial respiration for leukemia cell survival. Monika Komza, Jesminara Khatun, Jesse D. Gelles, Andrew P. Trotta, Ioana Abraham-Enachescu, Juan Henao, Ahmed Elsaadi, Andriana G. Kotini, Cara Clementelli, Jo Ann Arandela, Sebastian El Ghaity-Beckley, Agneesh Barua, Yiyang Chen, Mirela Berisa, Bridget K. Marcellino, Eirini P. Papapetrou, Masha V. Poyurovsky, Jerry Edward Chipuk. Cell Communication and Signaling
- Resolvin D1-mediated cellular crosstalk protects against MASH. Amaia Navarro-Corcuera, Yiwei Zhu, Fanglin Ma, Neha Gupta, Haley Asplund, Bruno Cogliati, Jerry E. Chipuk, Oren Rom, Scott L. Friedman, Brian E. Sansbury, Xin Huang, Bishuang Cai. JHEP Reports