Publications:183
Jia Chen, ScD
About Me
Dr. Jia Chen is Professor in the Departments of Environmental Medicine, Pediatrics and Oncological Sciences at the Icahn School of Medicine at Mount Sinai. She is the Director of the Molecular Epidemiology Lab the Senator Frank R. Lautenberg Environmental Health Sciences Laboratory where she leads a team of scientists examining the complex interactions between the environment and the genome/epigenome and how they contribute to human diseases. Dr. Chen is a member of the Mount Sinai Institute for Exposomic Research and its NIEHS-funded Center on Health and Environment Across the LifeSpan (HEALS).
Dr. Chen’s lab uses the latest molecular technologies to interrogate complex interactions between environment and epi/genome in relation to human health. The research strategy of her group is to develop and validate novel epi/genomic biomarkers to elucidate effects of environment and lifestyle (e.g. endocrine disruptors, metals, stress, and diet) on the epi/genome (e.g. transcriptome, methylome, metabolome, microRNA, genomic imprinting, and microbiome) and their ultimate impact on human diseases (e.g. cancer, reproductive abnormalities and neurodevelopmental deficits in children). By incorporating animal and in vitro models with population studies, her group uses transdisciplinary and integrative approach to explore functional variations of the epi/genome that are responsive to environmental insults and indicative of disease risk. As an example, her lab is actively carrying out research on the Developmental Origin and Health and Diseases (DOHaD) by interrogating placenta epi/genome to develop placenta-based biomarkers linking in utero exposure to developmental diseases. Her lab has recently been awarded an R01 from NIH to establish an atlas for human placenta. Additionally, her lab has been broadening the scope of research by integrating multi-omics approach in population studies with unique sample collections (such as cerebrospinal fluid) to explore the neurotoxicity of environmental exposure and their impact on mental health of pregnant women and their offspring. Dr. Chen has published over 170 research peer-reviewed papers in the area of molecular epidemiology and environmental health.
Dr. Chen is also a faculty member in the Graduate School of Biological Sciences at the Icahn School of Medicine at Mount Sinai. She was the recipient of the Senior Visiting Scientist Award and served on the Fellowship Selection Committee for the International Agency for Research on Cancer (IARC/WHO). Dr. Chen has served on multiple international committees including NIH study sections. She is currently on the editorial board of the journals Environmental Epigenetics and Cell & Bioscience.
She received her ScD in the fields of Toxicology and Environmental Engineering from Massachusetts Institute of Technology. She completed her postdoctoral training at Harvard Medical School.
Language
Position
Research Topics
Cancer, Cancer Genetics, Epigenetics, Gene Expressions, Genetics, Genomics, Molecular Epidemiology, Tumorigenesis
Multi-Disciplinary Training Areas
Cancer Biology [CAB], Disease Mechanisms and Therapeutics (DMT), Genetics and Genomic Sciences [GGS]
About Me
Dr. Jia Chen is Professor in the Departments of Environmental Medicine, Pediatrics and Oncological Sciences at the Icahn School of Medicine at Mount Sinai. She is the Director of the Molecular Epidemiology Lab the Senator Frank R. Lautenberg Environmental Health Sciences Laboratory where she leads a team of scientists examining the complex interactions between the environment and the genome/epigenome and how they contribute to human diseases. Dr. Chen is a member of the Mount Sinai Institute for Exposomic Research and its NIEHS-funded Center on Health and Environment Across the LifeSpan (HEALS).
Dr. Chen’s lab uses the latest molecular technologies to interrogate complex interactions between environment and epi/genome in relation to human health. The research strategy of her group is to develop and validate novel epi/genomic biomarkers to elucidate effects of environment and lifestyle (e.g. endocrine disruptors, metals, stress, and diet) on the epi/genome (e.g. transcriptome, methylome, metabolome, microRNA, genomic imprinting, and microbiome) and their ultimate impact on human diseases (e.g. cancer, reproductive abnormalities and neurodevelopmental deficits in children). By incorporating animal and in vitro models with population studies, her group uses transdisciplinary and integrative approach to explore functional variations of the epi/genome that are responsive to environmental insults and indicative of disease risk. As an example, her lab is actively carrying out research on the Developmental Origin and Health and Diseases (DOHaD) by interrogating placenta epi/genome to develop placenta-based biomarkers linking in utero exposure to developmental diseases. Her lab has recently been awarded an R01 from NIH to establish an atlas for human placenta. Additionally, her lab has been broadening the scope of research by integrating multi-omics approach in population studies with unique sample collections (such as cerebrospinal fluid) to explore the neurotoxicity of environmental exposure and their impact on mental health of pregnant women and their offspring. Dr. Chen has published over 170 research peer-reviewed papers in the area of molecular epidemiology and environmental health.
Dr. Chen is also a faculty member in the Graduate School of Biological Sciences at the Icahn School of Medicine at Mount Sinai. She was the recipient of the Senior Visiting Scientist Award and served on the Fellowship Selection Committee for the International Agency for Research on Cancer (IARC/WHO). Dr. Chen has served on multiple international committees including NIH study sections. She is currently on the editorial board of the journals Environmental Epigenetics and Cell & Bioscience.
She received her ScD in the fields of Toxicology and Environmental Engineering from Massachusetts Institute of Technology. She completed her postdoctoral training at Harvard Medical School.
Language
Position
Research Topics
Cancer, Cancer Genetics, Epigenetics, Gene Expressions, Genetics, Genomics, Molecular Epidemiology, Tumorigenesis
Multi-Disciplinary Training Areas
Cancer Biology [CAB], Disease Mechanisms and Therapeutics (DMT), Genetics and Genomic Sciences [GGS]