Jian Jin, PhD
Dr. Jian Jin is currently the Mount Sinai Endowed Professor in Therapeutics Discovery and Director of the Mount Sinai Center for Therapeutics Discovery at Icahn School of Medicine at Mount Sinai (Mount Sinai). He is also a tenured professor in Departments of Pharmacological Sciences, Oncological Sciences and Neuroscience and a Co-Leader of the Cancer Clinical Investigation Program at The Tisch Cancer Institute at Mount Sinai. Dr. Jin is an internationally recognized medicinal chemist and chemical biologist with >25 years of experience in small-molecule drug discovery. His laboratory is a leader in discovering novel degraders targeting oncoproteins, selective inhibitors of histone methyltransferases, and biased ligands of G protein-coupled receptors. Dr. Jin has published >200 peer-reviewed papers and delivered >100 invited talks. He is also an inventor of >70 issued U.S. patents and published international patent applications. In particular, Dr. Jin is one of several inventors of Daprodustat, a hypoxia-inducible factor (HIF) prolyl hydroxylase small-molecule inhibitor, which has been approved in the United States and Japan as an oral medication for the treatment of anemia caused by chronic kidney disease. Dr. Jin has been inducted to the National Academy of Inventors (NAI) as an NAI Fellow.
Dr. Jin received a Bachelor’s of Science degree in chemistry from University of Science and Technology of China in 1991 and a PhD in organic chemistry from the Pennsylvania State University in 1997. After completing a post-doctoral training at the Ohio State University, Dr. Jin joined GlaxoSmithKline as a medicinal chemist in 1998 and had been a manager of medicinal chemistry from 2003 to 2008. In 2008, Dr. Jin joined the Division of Chemical Biology and Medicinal Chemistry at the University of North Carolina at Chapel Hill (UNC) as an Associate Professor. He had also served as an Associate Director of Medicinal Chemistry in the Center for Integrative Chemical Biology and Drug Discovery at UNC from 2008 to 2014. Dr. Jin was recruited to Mount Sinai as a professor with tenure in 2014.
Cancer, Chromatin, Drug Design and Discovery, Epigenetics, Membrane Proteins/Channels, Neuroscience, Protein Degradation, Structural Biology
Multi-Disciplinary Training Areas
Cancer Biology [CAB], Disease Mechanisms and Therapeutics (DMT)