John F Crary, MD, PhD

http://www.crarylab.org/home.html Our research focuses on the molecular neuropathology of neurodegenerative diseases. Using an interdisciplinary approach, we are unravelling the molecular changes occurring in diseases with neurofibrillary tangles composed of the tau protein (i.e., tauopathies). This diverse set of brain diseases includes dementias, such as Alzheimer's disease, movement disorders, such as Parkinson's disease and related conditions, and the long-term sequelae of repetitive traumatic brain injury, or chronic traumatic encephalopathy. We are using histological, genetic, biochemical and molecular approaches to pinpoint underlying molecular and cellular triggers of these diseases. Recently, we have begun to deploy powerful artificial intelligence (machine learning)-based approaches, including computer vision, which is revolutionizing our approach to neurodegeneration. Major ongoing NIH-funded projects in the laboratory include: • Clinical, histopathological, biochemical and genetic studies of primary age-related tauopathy (R01NS095252) • Regulation of tau expression in Alzheimer's disease and aging (R01AG054008) • Clinicopathological studies of chronic traumatic encephalopathy (R01AG062348) • Clinicopathological studies of age-related neurodegeneration in HIV/AIDS (RF1AG060961)