John M Oropello
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John M Oropello, MD

Critical Care

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About Me

Language
English
Position
PROFESSOR | Surgery, PROFESSOR | Medicine
Hospital Affiliations
  • Mount Sinai Beth Israel
  • Mount Sinai Morningside
  • Mount Sinai Brooklyn
  • Mount Sinai Queens
  • The Mount Sinai Hospital
  • Mount Sinai West

Clinical Focus

Education

BA, Bernard Baruch College
MD, St. George's University School of Medicine
MD, St. George's University School of Medicine
, Coney Island Hospital
, Coney Island Hospital
, The Mount Sinai Hospital
Residency, Internal Medicine

South Brooklyn Health

Fellowship, Pulmonary Disease

South Brooklyn Health

Fellowship, Critical Care Medicine

Mount Sinai Hospital

Certifications

American Board of Internal Medicine

Awards

1990

Fellow-of-the-Year Award Critical Care Fellowship

The Mount Sinai Medical Center

1989

Consistent outstanding clinical performance during Internal Medicine Residency and Pulmonary Fellowship

Coney Island Hospital

1984

The Abdool Islami Award for Overall Academic Excellence

St. Georges' University, Grenada

1978

The President's Excellency Award for the

Baruch College Honors Program, New York

1978

The Muriel Lee Winokur Biology Scholarship

1978

Magna Cum Laude with Honors in Biology

Bernard Baruch College, New York, NY

Research

Research Projects Current:
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  • Kohli-Seth R, Oropello JM, Benjamin E, Manasia A, Leibowitz A, DelGiudice R, Hufanda J. A double blind, placebo-controlled, study of E5564, a lipid A antagonist, administered by twice daily intravenous infusions in patients with severe sepsis. \r\n\r\n
  • Benjamin E, Kohli-Seth R, Oropello JM, Leibowitz A, Manasia A, DelGiudice R, Hufanda J. Efficacy and safety of Drotrecogin (Alfa) in adult patients with early severe sepsis \r\n\r\n
  • Oropello JM, Kohli-Seth R, Benjamin E, Manasia A, Leibowitz A, DelGiudice R, Hufanda J. Central venous access techniques: successful cannulation of central veins upon withdrawal of needle vs. advancement. \r\n\r\n
  • Kohli-Seth R, Oropello JM, Benjamin E, Manasia A, Leibowitz A, DelGiudice R, Hufanda J. Resting energy expenditure in morbidly obese septic and non-septic patients \r\n\r\n
  • Oropello JM, Benjamin E, Manasia A, Kohli-Seth R, DelGiudice R, Hufanda J. A Phase 2 study to determine the efficacy of Sivelestat in patients with Acute Lung Injury \r\n\r\n
  • Benjamin E Kohli-Seth R, Oropello JM Manasia A, Hannon E, DelGiudice R, Hufanda J Benign postoperative hyperlactatemia in Neurosurgical Patients \r\n\r\n
  • Benjamin E, Oropello JM, Manasia A, Kohli-Seth R, DelGiudice R, Hufanda J. Beginning and Ending Supportive therapy (BEST) for the Kidney Study \r\n
  • Oropello JM, Benjamin E, Manasia A, Kohli-Seth R, DelGiudice R, Hufanda J. Phase 3 multicenter randomized placebo study of PHP in sepsis with Shock. \r\n\r\n
  • A Manasia, Benjamin E, Oropello JM, R. Kohli-Seth, R DelGiudice, J Hufanda. Limited transthoracic echocardiography (TTE) by non-cardiologist surgical intensivists. \r\n\r\n
  • Oropello JM, Benjamin E, Manasia A, R. Kohli-Seth, R DelGiudice, J Hufanda.. J4A-MC-EZZI. A phase 2b Study to determine the efficacy and safety of LY315920 in patients with severe sepsis. \r\n\r\n
  • S. Chhabra, Benjamin E, Oropello JM, Manasia A, Victor Murgolo, R DelGiudice, J Hufanda. Zeroing of hydraulic monitoring systems using laser guidance. \r\n\r\n
  • Benjamin E, Oropello JM, Manasia A, Altschuller-Felberg C, Hufanda J, DelGiudice R: Multicenter, Double Blind, Placebo Controlled, Randomized, Phase III Study of Tifacogin (Recombinant Tissue Factor Pathway Inhibitor [rTFPA/SC-59735]) in Severe Sepsis. \r\n\r\n
  • Benjamin E Oropello JM. Nierman D, Loren S, Hufanda J, DelGiudice R. Prospective study of anemia of critical illness and transfusion is critically ill patients. \r\n\r\n
  • Leibowitz A, Benjamin E, Oropello JM, Manasia, A, DelGiudice R., A randomized, open-labeled, pilot assessment of the effect of Protonix IV for injection (Pantoprazole Sodium) on gastric pH in ICU patients. \r\n\r\n
  • Oropello JM, Benjamin E, Altschuller-Felberg C, DelGiudice R, Hufanda J. . Open-label, comparative, randomized multicenter Phase 111 study of iv Synercid vs.Vancomycin or Nafcillin in the treatment of 380 patients with central venous catheter-related bacteremia. \r\n\r\n
  • Manasia A, Oropello JM, Benjamin E, Altschuller-Felberg C, DelGiudice R A Phase II, Dose-Ranging Evaluation of Safety and Efficacy of a-hANP for ARDS. \r\n\r\n
  • Kohli-Seth, Benjamin E. Oropello JM, Manasia, DelGiudice R, Hufanda J Amede F. The effect of continuous veno-venous hemofiltration (CVVH) on lung water as measured by transthoracic impedance analysis (TBIA). \r\n\r\n
  • Oropello JM, Altschuller-Felberg C, Benjamin E, Manasia A, DelGuidice R: rSP-c surfactant for the treatment of acute respiratory distress syndrome (ARDS), a randomized, multicenter, parallel group, controlled pilot study. \r\n\r\n
  • Oropello JM, Manasia A, Benjamin E, Altschuller-Felberg C, DelGuidice R: A phase II study to determine the efficacy and safety of LY315920 in patients with severe sepsis. \r\n \r\n
  • Benjamin E, Oropello JM, Manasia A, Altschuller-Felberg C Hufanda, J: Multicenter, single blind, placebo-controlled, randomized, dose escalation study of recombinant tissue factor pathway inhibitor (rTFOI/SC-59735) in severe sepsis. \r\n
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    Information regarding insurance participation and billing by this physician may be found on this page, and can also be obtained by contacting this provider directly. Because physicians insurance participation can change, the insurance information on this page may not always be up-to-date. Please contact this physician directly to obtain the most up-to-date insurance information.

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    Publications

    Publications:91
    Selected Publications

    Industry Relationships

    Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.

    Below are financial relationships with industry reported by Dr. Oropello during 2024 and/or 2025. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

    Consulting or Other Professional Services Examples include, but are not limited to, committee participation, data safety monitoring board (DSMB) membership

    • Association of Pulmonary and Critical Care Program Directors

    Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.