
Jordi Ochando, PhD
About Me
Jordi Ochando, Ph.D. is an Assistant Professor of Oncological Sciences and Director of the Flow Cytometry CoRE at the Icahn School of Medicine at Mount Sinai. The Ochando laboratory investigates the origin, development, and immune function of macrophages in organ transplantation. His laboratory has recently discovered that trained immunity represents a previously unrecognized pathway that mediates allograft rejection. To prevent the detrimental effects of trained macrophages, the Ochando laboratory uses a novel revolutionary targeted therapeutic delivery approach in which drug-loaded nanobiologics that specifically target macrophages in vivo and induce long-term allograft acceptance. This research represents a compelling framework for developing novel targeted therapies that promote immunological tolerance.
Language
English
Position
ASSISTANT PROFESSOR | Oncological Sciences, ASSISTANT PROFESSOR | Medicine, Nephrology, ASSISTANT PROFESSOR | Immunology & Immunotherapy
Research Topics
Cancer, Dendritic Cells, Growth, Immunological Tolerance, Transplantation
Multi-Disciplinary Training Areas
Immunology [IMM]
Education
BSc, University of Alicante
PhD, De Montfort University
Publications
Selected Publications
- A tumor-selective mRNA system enables precision cancer treatment. Magdalena M. Żak, Jimeen Yoo, Alberto Utrero-Rico, Wencke Walter, Gayatri Mainkar, Matthew Adjmi, Ann Anu Kurian, Ashikur Rahaman, Daniel Lozano Ojalvo, Jordi Ochando, Torsten Haferlach, Ramon E. Parsons, Filip K. Swirski, Lior Zangi. Molecular Therapy
- Erythropoietin prolongs graft survival in mice by counteracting trained immunity. Sofia Bin, Barbara Franchin, Irene Ramos, Marina Iskhakova, Johan Noble, Chiara Cantarelli, Nina Goerlich, Leonardo V. Riella, Jamil R. Azzi, Jordi Ochando, Paolo Molinari, Gaetano La Manna, Paolo Cravedi. American Journal of Transplantation
- Systemically inducing trained immunity overcomes solid tumors’ immunosuppressive microenvironment. Bram Priem, Lisa Willemsen, Tom Anbergen, Yuri van Elsas, Jeroen Deckers, David P. Schrijver, Stijn R.J. Hofstraat, Iris V. Messing, Jazz Munitz, Dionne Honing, Geoffrey Prévot, Yohana C. Toner, Judit Morla, William Wang, Anna Ranzenigo, Isabella Sirchia, Tomas Post, Raphaël Duivenvoorden, Ewelina Kluza, Glenn A.O. Cremers, Joost H.C.M. Kreijtz, Carlos Pérez-Medina, Mandy M.T.van Leent, Abraham J.P. Teunissen, Roy van der Meel, Yi Zhou, Chris Glass, Jordi Ochando, Leo A.B. Joosten, Zahi A. Fayad, Romana T. Netea-Maier, Mihai G. Netea, Menno P.J.de Winther, Thijs J. Beldman, Arjan W. Griffioen, Willem J.M. Mulder. Science advances