Josep Llovet, MD

A.-Establishment of sorafenib as standard of care in patients with advanced HCC (Llovet, New Engl J Med 2008). This breakthrough achievement establishes sorafenib as first line treatment for advanced HCC, and represents the first identification of survival advantages with systemic treatments. Identified by Nature Medicine as the most cited paper in oncology 2008-2010. Adopted by American (AASLD) and European (EASL-EORTC) guidelines of management of HCC.

 

B.-Establishment of chemoembolization as standard of care in patients with intermediate HCC. Evidence-based establishment through randomized controlled trials [Llovet, Lancet 2002] and meta-analysis [Llovet, Hepatology 2003] of chemoembolization as standard of care in patients with intermediate HCC. Adopted by American (AASLD) and European (EASL-EORTC) guidelines of management of HCC.

 

C.-Guidelines of management of HCC and ICC: Chair of EASL-EORTC Guidelines, 2012 (J Hepatol, 2012; Eur J Cancer 2012), and co-author of ILCA Guidelines of management of ICC (J Hepatol, 2014)

D.-Clinical trials. Dr. Llovet has participated as principal investigator in several international clinical trials that aimed to assess the tyrosine-kinase inhibitor sorafenib as adjuvant treatment after resection or ablative therapy (STORM trial. 1200 patients, 220 centers), sorafenib in combination with chemoembolization (SPACE trial. 400 patients, 120 centers), sorafenib in combination with erlotinib versus sorafenib at first line of treatment (SEARCH trial. 1000 patients), and the VEGFR1, VEGFR2, VEGFR3 and FGFR multi tyrosine-kinase inhibitor brivanib as a second line in patients who failed in the treatment with sorafenib (BRISK trial. 350 patients). Some of these clinical trials were published: Bruix J, J Hepatol. 2012; Llovet JM, J Clin Oncol. 2013; Llovet JM, Clin Cancer Res. 2012; Raoul JL, J Hepatol. 2012; Zhu AX, JCO 2014; Burrel M, J Hepatol. 2012; Forner A, J Hepatol. 2012; Roayaie S, Hepatology. 2013.