Julio A Aguirre-Ghiso, PhD
Endowed Chair, Mount Sinai Professor in Cancer Biology
Julio A. Aguirre-Ghiso, PhD, is Professor of Medicine (Hematology and Medical Oncology), Otolaryngology, and Oncological Sciences. He is Co-Leader of the Cancer Mechanisms Program at The Tisch Cancer Institute, Research Leader of the Metastasis Treatment Center, and Director of Head and Neck Cancer Basic Research in the Department of Otolaryngology. He is also a member of the Precision Immunology Institute and Black Family Stem Cell Institute. Dr. Aguirre-Ghiso was selected in 2018 as President Elect of the Metastasis Research Society. His work focuses on understanding the biology of residual cancer cells that persist in a dormant state after initial therapy. His research team led a paradigm shift, revealing novel cancer biology that diverges from the notion that cancer is perpetually proliferating. They discovered that reciprocal crosstalk between disseminated tumor cells and the microenvironment regulates the inter-conversion between dormancy and proliferation. This knowledge enables targeting minimal residual disease before it becomes clinically detectable and thus preventing recurrences. Their research is revealing ways to maintain residual cancer dormancy, kill dormant cancer cells, and utilize markers to determine the dormant or active state of disseminated disease.
Visit Dr. Aguirre-Ghiso's laboratory website.
Autophagy, Cancer, Cell Adhesion, Cell Motility, Extracellular Matrix, Gene Expressions, Gene Regulation, Integrins, Metastasis, Morphogenesis, Oncogenes, Signal Transduction, Stem Cells, Tumorigenesis
Multi-Disciplinary Training Areas
Cancer Biology [CAB]