Trey Hedden III, PhD

About Me

Dr. Hedden's research examines individual variation across neural systems that indicate vulnerability to aging processes, with the aim of understanding why some older adults will age gracefully while others will face impairment of these systems due to neurodegeneration, including preclinical Alzheimer’s disease and cerebrovascular disease. By applying advanced imaging tools and neuropsychological tests to identify individuals likely to face neurodegeneration, we can create and improve personalized diagnosis and intervention regimens that present the best opportunity to arrest neurodegeneration before damage leading to dementia occurs.

As Director of Neuroimaging and Biomarker Research in Aging and Alzheimer’s Disease at Mount Sinai and as the Core Lead of the Biomarker Core for the Alzheimer's Disease Research Center at Mount Sinai, he collaborates with colleagues in the Biomedical Engineering and Imaging Institute, the Ronald M. Loeb Center for Alzheimer’s Disease, in the Neurology, Radiology, and Neuroscience departments, and across institutions to accelerate advanced imaging research on aging and neurodegenerative diseases.

To learn more about research and career opportunities in the laboratory, please see: http://labs.icahn.mssm.edu/heddenlab/.

Language

English

Position

ASSOCIATE PROFESSOR | Neurology, ASSOCIATE PROFESSOR | Neuroscience, ASSOCIATE PROFESSOR | Diagnostic, Molecular and Interventional Radiology

Research Topics

Aging, Alzheimer's Disease, Brain, Brain Imaging, Cerebral Cortex, Cognitive Neuroscience, Diffusion Tensor Imaging, Hippocampus, MRI, Magnetic Resonance Imaging, Memory, Neuroscience, Positron Emission Tomography, Prefrontal Cortex

Multi-Disciplinary Training Areas

Neuroscience [NEU]

Research

This project investigates the regional impact of tau and amyloid associated with Alzheimer’s disease and of white matter damage of presumed vascular origin on the function of brain networks and associated cognitive abilities. We use MR-PET imaging to measure amyloid and tau in the brains of cognitively normal older adults and examine relationships to the architecture of brain networks that undergird cognitive function.

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.

Below are financial relationships with industry reported by Dr. Hedden III during 2025 and/or 2026. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Board Service

Mount Kisco Concert Association

Consulting or Other Professional Services Examples include, but are not limited to, committee participation, data safety monitoring board (DSMB) membership

National Institute On Aging/NIH/DHHS

Mount Sinai’s faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.