Publications:24
- Mount Sinai Doctors
Lewis Kaufman, MD
Nephrology
No Patient Experience Ratings
About Me
Language
English
Position
PROFESSOR | Medicine, Nephrology
Hospital Affiliations
- Mount Sinai Queens
- The Mount Sinai Hospital
Education
MD, State University of NY at Stony Brook School of Medicine
, Mount Sinai School of Medicine
, Mount Sinai School of Medicine
, Mount Sinai School of Medicine
BA, Columbia University
MD, State University of New York at Stony Brook
Residency, Internal Medicine
Mount Sinai Hospital
Fellowship, Nephrology
Mount Sinai Hospital
Certifications
American Board of Internal Medicine
Research
We study the glomerular podocyte, a critical cell in forming the kidney's ultrafiltration barrier. Podocyte injury occurs in all forms of proteinuric renal disease and is critical in mediating progression of renal failure. We have identified the sidekick gene family as being highly upregulated in podocytes in HIV-associated nephropathy (HIVAN). We have shown that the sidekicks function as homophilic adhesion molecules and that their over-expression in HIVAN alters how adjacent podocytes interact. We are interested in understanding how the sidekicks contribute to renal failure pathogenesis in both HIVAN and in other renal diseases.
Insurance Information
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Publications
Selected Publications
- SARS-CoV-2 viral protein ORF3A injures renal tubules by interacting with TRIM59 to induce STAT3 activation. Hong Cai, Ya Chen, Ye Feng, Morad Asadi, Lewis Kaufman, Kyung Lee, Thomas Kehrer, Lisa Miorin, Adolfo Garcia-Sastre, G. Luca Gusella, Leyi Gu, Zhaohui Ni, Shan Mou, John Cijiang He, Weibin Zhou. Molecular Therapy
- AMPK mediates regulation of glomerular volume and podocyte survival. Khadija Banu, Qisheng Lin, John M. Basgen, Marina Planoutene, Chengguo Wei, Anand C. Reghuvaran, Xuefei Tian, Hongmei Shi, Felipe Garzon, Aitor Garzia, Nicholas Chun, Arun Cumpelik, Andrew D. Santeusanio, Weijia Zhang, Bhaskar Das, Fadi Salem, Li Li, Shuta Ishibe, Lloyd G. Cantley, Lewis Kaufman, Kevin V. Lemley, Zhaohui Ni, John Cijiang He, Barbara Murphy, Madhav C. Menon. JCI insight
- DACH1 protects podocytes from experimental diabetic injury and modulates PTIP-H3K4Me3 activity. Aili Cao, Jianhua Li, Morad Asadi, John M. Basgen, Bingbing Zhu, Zhengzi Yi, Song Jiang, Tomohito Doke, Osama El Shamy, Niralee Patel, Paolo Cravedi, Evren U. Azeloglu, Kirk N. Campbell, Madhav Menon, Steve Coca, Weijia Zhang, Hao Wang, Ke Zen, Zhihong Liu, Barbara Murphy, John C. He, Vivette D. D’Agati, Katalin Susztak, Lewis Kaufman. Journal of Clinical Investigation
Industry Relationships
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.
Dr. Kaufman has not yet completed reporting of Industry relationships.
Mount Sinai’s faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.