Publications:5
Li Shen, PhD
About Me
Dr. Shen joined Mount Sinai in 2009 with a Ph.D. in computer science. He is currently a professor of bioinformatics with dual appointments at the department of Neuroscience and the department of Artificial Intelligence and Human Health. He has made contributions to large-scale sequencing analysis, bioinformatic tools development and machine learning applications to medical imaging and epigenomics. His current research interests include the applications of machine learning in healthcare and genomics. He has more than 100 publications with >12,000 total citations. See his Google scholar page for a full list of his publications. Visit Li Shen's Laboratory of Bioinformatics for more information on his research activities.
Language
English
Position
PROFESSOR | Neuroscience
Research Topics
Bioinformatics, Biomedical Informatics, Computational Biology, Epigenomics, Image Analysis, Mathematical Modeling of Biomedical Systems, Mathematical and Computational Biology
Multi-Disciplinary Training Areas
Artificial Intelligence and Emerging Technologies in Medicine [AIET], Genetics and Genomic Sciences [GGS], Neuroscience [NEU]
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BS, Fudan University
PhD, Nanyang Technological University
Postdoc, University of California San Diego
Awards
2022
Google Cloud Research Innovator
2019
4D Technology Development
Icahn School of Medicine at Mount Sinai
2006
Interfaces in Science Award
Burroughs Wellcome Funds
2000
ViaVoice National Campus Application Contest Excellence Prize
IBM
Research
From 2009-present, the Shen lab has analyzed 10,000s of NGS samples with a total storage of more than 100 TB. The results have generated numerous publications in top-tier journals, such as Nature, Science, Neuron, Nature Neuroscience and Genome Biology. The Shen lab has also produced some of the most popular bioinformatic tools, such as ngs.plot (data mining and visualization of NGS data), diffReps (ChIP-seq differential analysis) and GeneOverlap (gene lists overlapping analysis).
Publications
Selected Publications
- CREB Binding at the Zfp189 Promoter Within Medium Spiny Neuron Subtypes Differentially Regulates Behavioral and Physiological Adaptations Over the Course of Cocaine Use. Collin D. Teague, Joseph A. Picone, William J. Wright, Caleb J. Browne, Gabriella M. Silva, Rita Futamura, Angélica Minier-Toribio, Molly E. Estill, Aarthi Ramakrishnan, Freddyson J. Martinez-Rivera, Arthur Godino, Eric M. Parise, Kyra H. Schmidt, Nathalia V. Pulido, Zachary S. Lorsch, Jee Hyun Kim, Li Shen, Rachael L. Neve, Yan Dong, Eric J. Nestler, Peter J. Hamilton. Biological Psychiatry
- Prenatal Δ<sup>9</sup>-Tetrahydrocannabinol Exposure in Males Leads to Motivational Disturbances Related to Striatal Epigenetic Dysregulation. Randall J. Ellis, Anissa Bara, Claudia A. Vargas, Amy L. Frick, Eddie Loh, Joseph Landry, Teddy O. Uzamere, James E. Callens, Qammarah Martin, Prashanth Rajarajan, Kristen Brennand, Aarthi Ramakrishnan, Li Shen, Henrietta Szutorisz, Yasmin L. Hurd. Biological Psychiatry
- Chronic Intermittent Hypoxia Enhances Pathological Tau Seeding, Propagation, and Accumulation and Exacerbates Alzheimer-like Memory and Synaptic Plasticity Deficits and Molecular Signatures. Syed Faraz Kazim, Abhijeet Sharma, Sivaprakasam R. Saroja, Joon Ho Seo, Chloe S. Larson, Aarthi Ramakrishnan, Minghui Wang, Robert D. Blitzer, Li Shen, Catherine J. Peña, John F. Crary, Larissa A. Shimoda, Bin Zhang, Eric J. Nestler, Ana C. Pereira. Biological Psychiatry