Ling-Shiang Chuang, PhD

Dr. Chuang is an Assistant Professor for the Department of Pathology, Molecular and Cell-Based Medicine Dr. Chuang has years of experience conducting functional studies on genetic mutations underlying susceptibility to inflammatory bowel disease (IBD). He has a strong background in the fields of genetics, genomics, biochemistry, molecular, and developmental biology. In his 2021 publications in Gastroenterology, Dr. Chuang applied cutting-edge single-cell RNAseq technologies in humans, zebrafish IBD models, immune cells, and cell lines to identified potential therapeutics of IBD based on precision genetics. His 2019 publication in Disease Models and Mechanisms established a novel zebrafish intestinal injury models for IBD in vivo functional studies. With his current work, Dr. Chuang is utilizing zebrafish to model intestinal injury, bacterial exposures, and medications to define epithelial in vivo responses relevant to human IBD. His 2016 publication in Gastroenterology identified an Ashkenazi Jewish-predominant heterozygous frameshift mutation in CSF2RB, increasing the risk for Crohn’s disease attenuates GM-CSF signaling.