Louis R Depalo
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Louis R Depalo, MD

Internal Medicine, Pulmonary Medicine (Lung), Critical Care

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About Me

Dr. DePalo is currently the Medical Director of the Health Center at Hudson Yards. He formerly served as the System Clinical Director of the Respiratory Institute, Mount Sinai Health System and Professor of Pulmonary, Critical Care and Sleep Medicine and Adjunct Professor of Infectious Disease, Icahn School of Medicine. Dr. DePalo was a UNOS certified physician with clinical interest in advanced lung diseases including ILD, hypersensitivity pneumonitis, vasculitis, sarcoidosis, Bronchiectasis, refractory asthma, and lung cancer.  He is Co-Director of the Bronchiectasis program and founding member of the Hospital based PERT (pulmonary embolism response team).  Dr. DePalo Chairs the system wide Pharmacy and Therapeutics committee and has been active in adoption of new EMR and adjunct technologies to advance patient care and Education.   Dr. DePalo, M.D. is a graduate of Georgetown University and New York Medical College. Dr. DePalo has a graduate degree in Human Physiology and extensive research experience in cell and molecular biology. Dr. DePalo's extensive include research interests in the study of human airway smooth muscle cell function, sarcoidosis and advanced lung diseases. Following many years of productive study in the Cardiovascular Institute of The Mount Sinai Hospital, Dr. DePalo directed his research efforts to clinical medicine. In collaboration with Dr. Alvin Teirstein, Dr. DePalo participated in a case controlled epidemiology study of the causes of sarcoidosis (ACCESS Trial) and the study of the genetics of sarcoidosis (SAGA). Dr. DePalo has served as PI for industry sponsored trial on inhaled Liposomal Amikacin which has just had FDA approval and currently investigating new technology for early detection of lung cancer with Bioaffinity sputum assay. Furthermore, in collaboration with Cardiovascular Institute and The Recanati-Miller Transplantation Institute, Dr. DePalo has served as a consultant with the Pulmonary Hypertension, heart Transplant and former Lung Transplant Programs. He served as consultant for the advanced heart failure team, together with the LVAD and ECMO programs. Dr. DePalo is also a founding member of the Mount Sinai pulmonary embolism response team (PERT).  Research in these areas includes the application of new therapeutic and diagnostic modalities to the treatment of patients with these disorders.


PROFESSOR | Medicine, Pulmonary, Critical Care and Sleep Medicine, PROFESSOR | Medicine, Infectious Diseases
Hospital Affiliations
  • Mount Sinai Morningside
  • Mount Sinai Beth Israel
  • Mount Sinai Brooklyn
  • Mount Sinai Queens
  • The Mount Sinai Hospital
  • Mount Sinai West