Maria Soledad Sosa

Maria Soledad Sosa, PhD

About Me

My undergraduate training consisted in the study of melanoma biology, in the laboratory of Osvaldo Podhajcer at the renowned Leloir Institute where I focused in the identification of novel melanoma signaling targets using proteomics. From this training phase I published a very complete story in Proteomics (Sosa MS, et al., Proteomics 2007). My Ph.D. training program was carried out at the University of Pennsylvania in a joint program with the University of Buenos Aires. This training was under the mentorship of Dr. Marcelo Kazanietz, a well-recognized scientist in cell signaling studies in prostate and breast cancer. During this time I focused on the study of P-Rex1, a Rac-GEF protein, and how this factor contributes to the malignancy of mammary tumor cells. We demonstrated that P-Rex1 is important for migration and tumor development of breast cancer cells (Sosa MS, et al., Mol. Cell 2010). In 2010, I joined Dr. Julio Aguirre-Ghiso laboratory and since then I have been working in understand how tumor cell dormancy is established once tumor cell disseminate to secondary organs. In this work I was able to link the orphan nuclear receptor NR2F1 to a novel function during tumor cell dormancy (Sosa Nat. Com 2015). I found that NR2F1 is required for malignant cells to undergo dormancy and it does this by upregulating the expression of cell cycle inhibitors and decreasing cyclin D1 levels. I also found that NR2F1 induces the mRNA levels of NANOG, SOX2 and OCT-4 in dormant cells. The latter result is surprising and important since it is the first time that a connection between self-renewal genes and quiescence programs has been established in tumor cells and dormancy. In 2012 I was awarded a DoD Breast Cancer Postdoctoral Grant to study the processes responsible for early dissemination and target organ colonization by breast tumor cells. In 2016 I was promoted to Assistant Professor position in the Department of Pharmacological Sciences, Icahn School of medicine at Mount Sinai.

Link to Sinai lab portal: 

ASSISTANT PROFESSOR | Pharmacological Sciences, ASSISTANT PROFESSOR | Oncological Sciences
Multi-Disciplinary Training Areas

Cancer Biology [CAB], Pharmacology and Therapeutics Discovery [PTD]