Matheus Victor, PhD

Matheus Victor, PhD, is an investigator of the Institute for Regenerative Medicine, the Ronald M. Loeb Center for Alzheimer’s Disease and the Friedman Brain Institute. Dr. Victor is an assistant professor in the Department of Neuroscience, and in the Department of Cell, Developmental and Regenerative Biology. He joins the faculty of the Icahn School of Medicine at Mount Sinai as an NIH FIRST Faculty Scholar and a Howard Hughes Medical Institute Hanna Gray Faculty Fellow.

Dr. Victor earned his Ph.D. in Neuroscience from Washington University in St. Louis where he pioneered a novel cellular reprogramming approach to study the contribution of aging to neurodegeneration. Dr. Victor conducted his postdoctoral training at MIT where he investigated how genetic susceptibility in microglia, the brain-resident immune cells, contributes to the pathobiology of Alzheimer’s disease.

At Mount Sinai, the Victor lab leverages 3D stem cell technologies, CRISPR-based tools, post-mortem human brain samples, and mouse models to elucidate the molecular, cellular, and systems-level consequences of glial perturbations associated with neurodegenerative diseases to the function of neural circuits.

Learn more about the Victor lab: www.victor-lab.com

Ongoing research interests include:

• Neuron-glia interactions in the pathophysiology of neurodegenerative diseases.
• Mechanisms of neuronal network assembly, remodeling, and degeneration with 3D cell culture models of the human brain.
• Molecular, cellular and circuit level mechanisms governing neuropsychiatric symptoms of Alzheimer’s disease.