Publications:427
Matilde Inglese, MD, PhD
About Me
Dr. Matilde Inglese is a Professor of Neurology, Radiology, and Neuroscience at Icahn School of Medicine at Mount Sinai. She received her medical degree magna cum laude from the University of Genoa, Italy and earned a PhD degree from the same university after her formal training in neurology. Dr. Inglese completed her post-doctoral training in Neuroimaging at San Raffaele Hospital, Milan, Italy. Then, supported by the National Multiple Sclerosis Society, Dr. Inglese completed a fellowship in neuroimaging at New York University.
Her current research, supported by the National Institute of Health, focuses on the development and application of new structural and functional magnetic resonance imaging techniques at high and ultra-high field strength, to study multiple sclerosis and other neurological diseases. This work aims to identify the mechanisms of degeneration which lead to the accumulation of irreversible clinical disability, and to provide surrogate markers to monitor the efficacy of neuroprotective treatments in vivo.
Dr. Inglese serves as a member of the National Institute of Health study sections, and she is a member of the American Academy of Neurology and the International Society of Magnetic Resonance in Medicine. Dr. Inglese is author and co-author of several original contributions published in the neurological and radiological scientific literature and several book chapters on clinical and basic research aspects of multiple sclerosis.
Visit Dr. Inglese's laboratory website at http://icahn.mssm.edu/research/labs/inglese-laboratory
Language
English
Position
ADJUNCT PROFESSOR | Neurology, ADJUNCT PROFESSOR | Diagnostic, Molecular and Interventional Radiology, ADJUNCT PROFESSOR | Neuroscience
Research Topics
Blood-Brain Barrier, Brain Imaging, Cerebellum, Cognitive Neurology, Diffusion Tensor Imaging, Microglia, Mitochondria, Multiple Sclerosis, Myelination, Oxidative Stress, Regeneration, Rehabilitation, Spinal Cord, Synaptic Plasticity
Clinical Focus
- Multiple Sclerosis
- Multiple Sclerosis Imaging
Education
MD, University of Genoa
Residency, University of Genoa
Fellowship, Neuroimaging Research Unit, San Raffaele Hospital
Fellowship, New York University, Radiology and Neurology Department
PhD, University of Genoa
Research
It has been suggested that the accumulation of intra-axonal sodium represents a key factor in the degenerative process of MS. Changes in tissue sodium concentration can be measured in vivo by single quantum Sodium MR Imaging. The application of triple quantum sodium filtration, allows the measurement of intracellular sodium concentration. Using ultra-high field MRI (7T) in collaboration with the Center for Biomedical Imaging at NYU we are investigating whether sodium-related brain tissue damage is critical for the accumulation of clinical disability in MS
Publications
Selected Publications
- Increased functional network connectivity following cognitive rehabilitation in progressive multiple sclerosis with moderate to severe disabilty: findings from the CogEx study. Francesco Romanò, Paola Valsasina, Matteo Albergoni, Maria Pia Amato, Giampaolo Brichetto, Jeremy Chataway, Nancy D. Chiaravalloti, Gary Cutter, Ulrik Dalgas, John DeLuca, Rachel Farrell, Peter Feys, Jennifer Freeman, Matilde Inglese, Emilio Cipriano, Cecilia Meza, Robert W. Motl, Amber Salter, Brian M. Sandroff, Anthony Feinstein, Maria A. Rocca, Massimo Filippi, Michele Curran, Roberto Hernandez, Matteo Pardini, Maria Cellerino, Elisa Pelosin, Eleonora Colombo, Chiara Pollio, Filippo Gerli, Fedrica Vannetti, Sara Della Bella, Irene Mosca, Guido Pasquini, Claudia Niccolai, Rebecca Bex Walters, Marie Braisher, James Braisher, Holly Wilkinson, Catherine Smith, Alexsandra Pietrusz, Patrizia Pajak, Michelle Koch, Petra Silic, Jessica Baird, Catherine Danielle Jones, Brendon Truax, Ashlie Kristin Ithurburn, Laura Toll, Laura Kenton. Journal of Neurology
- Efficacy and safety of ocrelizumab in primary progressive multiple sclerosis, including older patients and those with more advanced disease (ORATORIO-HAND): a multicentre, double-blind, randomised, placebo-controlled, phase 3b study. Gavin Giovannoni, Laura Airas, Riley Bove, Gary R. Cutter, Maciej Czarnecki, Jelena Drulovic, Jeremy Hobart, Jens Kuhle, Xavier Montalban, Krzysztof W. Selmaj, Carmen Tur, Jerry S. Wolinsky, Anna Baldinotti, Ulrike Bonati, Licinio Craveiro, Caroline Giacobino, Marianna Manfrini, Hans Martin Schneble, Paula Stevenson, Qing Wang, Ke Yang, Jiwon Oh, Michael Barnett, Christopher Dwyer, Richard Macdonell, Mark Marriott, Marion Simpson, Veronica Popescu, Vincent Van Pesch, Barbara Willekens, Hristo Lilovski, Ivan Milanov, Plamen Tsvetanov, Alexander Macdougall, James Marriott, John Roger McKelvey, Jiwon Oh, Michael Thorne, Reza Vosoughi, Carlos Navas, Cesar Franco Ruiz, Mario Habek, Vanja Basic Kes, Spomenka Kidjemet-Piskac, Laura Airas, Giovanni Castelnovo, Pierre Clavelou, Jerome De Seze, David Laplaud, Matilde Inglese. The Lancet
- Vocational rehabilitation for people with multiple sclerosis: A systematic scoping review of international evidence. Carlotta Gualco, Erica Grange, Federica Rotondi, Marco Salivetto, Elena Pignattelli, Tommaso Manacorda, Maria Grazia Grasso, Giorgia Presicce, Matilde Inglese, Lorenza Nasone, Paolo Durando, Guglielmo Dini, Benedetta Persechino, Giampaolo Brichetto, Michela Ponzio. PLoS ONE