Matilde Inglese, MD, PhD

About Me

Dr. Matilde Inglese is a Professor of Neurology, Radiology, and Neuroscience at Icahn School of Medicine at Mount Sinai. She received her medical degree magna cum laude from the University of Genoa, Italy and earned a PhD degree from the same university after her formal training in neurology. Dr. Inglese completed her post-doctoral training in Neuroimaging at San Raffaele Hospital, Milan, Italy. Then, supported by the National Multiple Sclerosis Society, Dr. Inglese completed a fellowship in neuroimaging at New York University.

Her current research, supported by the National Institute of Health, focuses on the development and application of new structural and functional magnetic resonance imaging techniques at high and ultra-high field strength, to study multiple sclerosis and other neurological diseases. This work aims to identify the mechanisms of degeneration which lead to the accumulation of irreversible clinical disability, and to provide surrogate markers to monitor the efficacy of neuroprotective treatments in vivo.

Dr. Inglese serves as a member of the National Institute of Health study sections, and she is a member of the American Academy of Neurology and the International Society of Magnetic Resonance in Medicine. Dr. Inglese is author and co-author of several original contributions published in the neurological and radiological scientific literature and several book chapters on clinical and basic research aspects of multiple sclerosis.

Visit Dr. Inglese's laboratory website at http://icahn.mssm.edu/research/labs/inglese-laboratory

Language

English

Position

ADJUNCT PROFESSOR | Neurology, ADJUNCT PROFESSOR | Neuroscience, ADJUNCT PROFESSOR | Diagnostic, Molecular and Interventional Radiology

Research Topics

Blood-Brain Barrier, Brain Imaging, Cerebellum, Cognitive Neurology, Diffusion Tensor Imaging, Microglia, Mitochondria, Multiple Sclerosis, Myelination, Oxidative Stress, Regeneration, Rehabilitation, Spinal Cord, Synaptic Plasticity

Clinical Focus

Multiple Sclerosis
Multiple Sclerosis Imaging

Education

MD, University of Genoa

Residency, University of Genoa

Fellowship, Neuroimaging Research Unit, San Raffaele Hospital

Fellowship, New York University, Radiology and Neurology Department

PhD, University of Genoa

Research

It has been suggested that the accumulation of intra-axonal sodium represents a key factor in the degenerative process of MS. Changes in tissue sodium concentration can be measured in vivo by single quantum Sodium MR Imaging. The application of triple quantum sodium filtration, allows the measurement of intracellular sodium concentration. Using ultra-high field MRI (7T) in collaboration with the Center for Biomedical Imaging at NYU we are investigating whether sodium-related brain tissue damage is critical for the accumulation of clinical disability in MS

Publications

Publications:413

Selected Publications

View All Publications

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.

Below are financial relationships with industry reported by Dr. Inglese during 2025 and/or 2026. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Outside Employment

University of Genoa

Mount Sinai’s faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.