Matthew A Levin
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Matthew A Levin, MD


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About Me

Dr. Levin is a board-certified Cardiac Anesthesiologist and Clinical Informaticist, Director of Research Informatics for the Department of Anesthesiology, Perioperative & Pain Medicine and Director of the Clinical Data Science Team for the Mount Sinai Health System. In addition, he holds joint appointments in the Department of Genetics and Genomics Sciences and Department of AI and Human Health. Dr. Levin began his career by working the software industry and has continued to maintain an interest and expertise in technology. As Co-Director of the Clinical Data Science Team, he has successfully overseen the implementation of a real-time multi-modal streaming data science pipeline. This pipeline is used to deploy operational machine learning models at the point of care.

Dr. Levin’s primary research interests are clinical informatics, intra-operative physiology and peri-operative outcomes, and preoperative genomics. He has published multiple large (30-50,000 patient) cohort studies examining the relationship between intra-operative physiology and postoperative outcomes. Several of these findings have been controversial, e.g., that intraoperative hemodynamic variability is associated with decreased mortality, and that low intraoperative tidal volume is associated with higher mortality. These studies have been widely cited within the anesthesiology literature. In the area of clinical informatics he has been PI or co-PI on two large pragmatic decision support trials examining the utility of clinician alerts (NCT04026555, NCT01545596).

In 2015 Dr. Levin was awarded a starter grant from the Society of Cardiovascular Anesthesiologists to investigate the genomics of vasoplegia, a state of profound hypotension sometimes seen after cardiopulmonary bypass. Preliminary analysis identified several potential variants associated with the condition. Work is ongoing to validate and replicate these findings. More recently he investigated the relationship between self-reported ancestry and intra-operative blood pressure response to phenylephrine, finding that there is a significant difference in response between patients of Hispanic, African American, and European ancestry. During the COVID-19 crisis he led a multi-disciplinary group to drive innovation in ventilators (the Mount Sinai HELPS Innovate Lab) by working with both the NASA Jet Propulsion Laboratory, and industry partners.

Dr. Levin sits on the executive committee of the Mount Sinai Clinical Intelligence Center where he helps set priorities and agenda for the center, and on the Data Use Committee, where he helps ensure the protection of patient data.


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PROFESSOR | Anesthesiology, Perioperative & Pain Medicine, PROFESSOR | Genetics and Genomic Sciences
Hospital Affiliations
  • The Mount Sinai Hospital
Research Topics

Anesthesia, Bioinformatics, Cardiovascular, Genomics

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