
Michael A Schotsaert, PhD
About Me
Dr. Schotsaert obtained a master’s degree in bio-engineering (2003), a master’s degree in molecular medical biotechnology (2004) and a PhD in molecular biotechnology (2011) from Ghent University (Belgium). In 2013 he joined the lab of Dr. Adolfo García-Sastre for postdoctoral work as an immunologist and vaccinologist and has since established different vaccination and infection models (BSL2, BSL3 and BSL3+). Dr. Schotsaert’s work focuses on influenza, ZIKA and SARS-CoV-2 viruses and he has over fifteen years of experience with studying host-pathogen interactions in preclinical infection models to immunologically characterize and validate candidate vaccines, adjuvants and antiviral treatments. From an immunological point of view, his research focuses on the interplay and cross-talk between innate and adaptive immune responses during virus infection. Since January 2020, the Schotsaert laboratory is established in the Department of Microbiology and the Global Health and Emerging Pathogens Institute at the Icahn School of Medicine at Mount Sinai in New York, and together with his team he continues to study host-immune responses to infection and vaccination in the context of comorbidities like obesity, diabetes and advanced age.
Language
English
Position
ASSOCIATE PROFESSOR | Immunology & Immunotherapy, ASSOCIATE PROFESSOR | Microbiology
Research Topics
Aging, Antivirals, B Cells, Dendritic Cells, Diabetes, Immunology, Influenza Virus, Interferon, Knockout Mice, Macrophage, Microbiology, Mucosal Immunology, Obesity, SARS Virus, Staphylococcus Aureus, T Cells, Vaccine Development, Viruses and Virology
Multi-Disciplinary Training Areas
Microbiology [MIC]
Education
PhD in molecular biotechnology, Ghent University
master's in bio-engineering sciences, Ghent University
master's in molecular medical biotechnology, Ghent University
Research
Publications
Selected Publications
- Prolonged but finite antigen presentation promotes reversible defects of “helpless” memory CD8<sup>+</sup> T cells. Verena van der Heide, Gabriel Laghlali, Bennett Davenport, Beatrice Cubitt, Vladimir Roudko, Daniel Choo, Kevin Jhun, Etienne Humblin, Abishek Vaidya, Krista Angeliadis, Travis Dawson, Glaucia Furtado, Alice O. Kamphorst, Michael Schotsaert, Rafi Ahmed, Juan Carlos de la Torre, Dirk Homann. Immunity
- A ventilated perfused lung model platform to dissect the response of the lungs to viral infection. I. Deniz Derman, Mecit Altan Alioglu, Joseph Christakiran Moses, Zissis C. Chroneos, Yasar Ozer Yilmaz, Dishary Banerjee, Jonathan Koff, Syed Hasan Askari Rizvi, Danielle Nicole Klunk, Nazmiye Celik, Sirisha Pochareddy, Todd M. Umstead, Ilayda Namli, Sarah E. Holton, Carmen Mikacenic, Jessica L. Thompson, Diana Cadena Castaneda, Danielle Reifsnyder Hickey, Momoka Nagamine, Prajakta Warang, Michael Schotsaert, Phylip Chen, Mark E. Peeples, Karolina Palucka, Ibrahim T. Ozbolat. Trends in Biotechnology
- Identification and targeting of regulators of SARS-CoV-2–host interactions in the airway epithelium. Brooke Dirvin, Heeju Noh, Lorenzo Tomassoni, Danting Cao, Yizhuo Zhou, Xiangyi Ke, Jun Qian, Sonia Jangra, Michael Schotsaert, Adolfo García-Sastre, Charles Karan, Andrea Califano, Wellington V. Cardoso. Science advances