
Michael A Schotsaert, PhD
About Me
Dr. Schotsaert obtained a master’s degree in bio-engineering (2003), a master’s degree in molecular medical biotechnology (2004) and a PhD in molecular biotechnology (2011) from Ghent University (Belgium). In 2013 he joined the lab of Dr. Adolfo García-Sastre for postdoctoral work as an immunologist and vaccinologist and has since established different vaccination and infection models (BSL2, BSL3 and BSL3+). Dr. Schotsaert’s work focuses on influenza, ZIKA and SARS-CoV-2 viruses and he has over fifteen years of experience with studying host-pathogen interactions in preclinical infection models to immunologically characterize and validate candidate vaccines, adjuvants and antiviral treatments. From an immunological point of view, his research focuses on the interplay and cross-talk between innate and adaptive immune responses during virus infection. Since January 2020, the Schotsaert laboratory is established in the Department of Microbiology and the Global Health and Emerging Pathogens Institute at the Icahn School of Medicine at Mount Sinai in New York, and together with his team he continues to study host-immune responses to infection and vaccination in the context of comorbidities like obesity, diabetes and advanced age.
Language
English
Position
ASSOCIATE PROFESSOR | Immunology & Immunotherapy, ASSOCIATE PROFESSOR | Microbiology
Research Topics
Aging, Antivirals, B Cells, Dendritic Cells, Diabetes, Immunology, Influenza Virus, Interferon, Knockout Mice, Macrophage, Microbiology, Mucosal Immunology, Obesity, SARS Virus, Staphylococcus Aureus, T Cells, Vaccine Development, Viruses and Virology
Multi-Disciplinary Training Areas
Microbiology [MIC]
Education
PhD in molecular biotechnology, Ghent University
master's in bio-engineering sciences, Ghent University
master's in molecular medical biotechnology, Ghent University
Research
Publications
Selected Publications
- Influenza hijacks myeloid cells to inflict type-I interferon-fueled damage in the heart. Jeffrey Downey, Ana Oliveira-Coelho, Máté G. Kiss, Gabriel Laghlali, Alexander Leunig, Emir Radkevich, Laszlo Halasz, Martin Umali, Joana Ferreira da Silva, Madeline L. Eller, Matteo Gianeselli, Magdalena M. Żak, Haley E. Randolph, Gabriel Caumartin, Wolfram C. Poller, Henrike Janssen, Laura L. Koekkoek, Jamshid Abdul-Ghafar, Pacific Huynh, Darwin D'Souza, Vladimir Roudko, Sheqouia Nauta, Jazz Munitz, Xisheng Li, Thomas Rathner, Ziche Chen, Anh Phan, Abigail Glick, Katarzyna Cialowicz, Zhihong Chen, Seunghee Kim-Schulze, Seonghun Yoon, Matthias Nahrendorf, Susmita Sahoo, Miriam Merad, Adolfo García-Sastre, Cameron S. McAlpine, Gustav J. Strijkers, Viviana Simon, Rachel Brody, Saurabh Mehandru, Zahi A. Fayad, Benjamin P. Kleinstiver, Lior Zangi, Mandy M.T. van Leent, Michael Schotsaert, Filip K. Swirski. Immunity
- Transient lung eosinophilia during breakthrough influenza infection in vaccinated mice is associated with protective and balanced Type 1/2 immune responses. Lauren A. Chang, Stephen T. Yeung, Prajakta Warang, Moataz Noureddine, Gagandeep Singh, Brett T. Webb, Eleanor Burgess, Michael Schotsaert. Journal of Virology
- Human monoclonal antibodies targeting A35 protect from death caused by mpox. Raianna F. Fantin, Meng Yuan, Seok Chan Park, Bailey Bozarth, Hallie Cohn, Maxinne Ignacio, Patricia Earl, Alesandro Civljak, Gabriel Laghlali, Ding Zhang, Xueyong Zhu, Jameson Crandell, Valter Monteiro, Jordan J. Clark, Catherine Cotter, Martin Burkhardt, Gagandeep Singh, Prajakta Warang, Juan García-Bernalt Diego, Komal Srivastava, Luz A. Lugo, Lauren Pischel, Inci Yildirim, Saad B. Omer, Daniel da Silva, Florian Krammer, Goran Bajic, Viviana Simon, Michael Schotsaert, Carolina Lucas, Ian A. Wilson, Bernard Moss, Camila H. Coelho. Cell