Min Xue, PhD

My group works on developing molecular tools and bioanalytical strategies that enable a deeper understanding and effective treatments of human diseases, such as cancer. Specifically, we are interested in the following areas:

• Interrogation and interpretation of cell metabolic activities and protein signaling dynamics with single-cell resolution, with the goal of identifying potential disease vulnerabilities.

• Expanding the repertoire of multicyclic peptides to access unique 3D diversifiable chemical space, with the aim of facilitating drug discovery.

• Creating therapeutic and diagnostic tools targeting protein-protein interactions, with a focus on the “undruggable” intrinsically disordered proteins, such as MYC and MYCN.

• Establishing a panel of peptide-based delivery tags that can deliver drug molecules to specific locations at the intracellular, cellular, and organ levels.

Overall, we take a collaborative and convergent approach and innovate through the interdisciplinary sciences involving bioanalytical methods, chemical biology, drug discovery, medicinal chemistry, systems biology, and cancer biology.

 

Lab website: http://xuelab.org