Min Xue, PhD
About Me
My group works on developing molecular tools and bioanalytical strategies that enable a deeper understanding and effective treatments of human diseases, such as cancer. Specifically, we are interested in the following areas:
- Interrogation and interpretation of cell metabolic activities and protein signaling dynamics with single-cell resolution, with the goal of identifying potential disease vulnerabilities.
- Expanding the repertoire of multicyclic peptides to access unique 3D diversifiable chemical space, with the aim of facilitating drug discovery.
- Creating therapeutic and diagnostic tools targeting protein-protein interactions, with a focus on the “undruggable” intrinsically disordered proteins, such as MYC and MYCN.
- Establishing a panel of peptide-based delivery tags that can deliver drug molecules to specific locations at the intracellular, cellular, and organ levels.
Overall, we take a collaborative and convergent approach and innovate through the interdisciplinary sciences involving bioanalytical methods, chemical biology, drug discovery, medicinal chemistry, systems biology, and cancer biology.
Lab website: http://xuelab.org
Language
Position
Research Topics
Biochemistry, Biomedical Sciences, Biophysics, Cancer, Cell Biology, Drug Design and Discovery, Epigenetics, Imaging, Personalized Medicine, Pharmacology, Proteases, Trafficking
Multi-Disciplinary Training Areas
Cancer Biology [CAB], Disease Mechanisms and Therapeutics (DMT)
About Me
My group works on developing molecular tools and bioanalytical strategies that enable a deeper understanding and effective treatments of human diseases, such as cancer. Specifically, we are interested in the following areas:
- Interrogation and interpretation of cell metabolic activities and protein signaling dynamics with single-cell resolution, with the goal of identifying potential disease vulnerabilities.
- Expanding the repertoire of multicyclic peptides to access unique 3D diversifiable chemical space, with the aim of facilitating drug discovery.
- Creating therapeutic and diagnostic tools targeting protein-protein interactions, with a focus on the “undruggable” intrinsically disordered proteins, such as MYC and MYCN.
- Establishing a panel of peptide-based delivery tags that can deliver drug molecules to specific locations at the intracellular, cellular, and organ levels.
Overall, we take a collaborative and convergent approach and innovate through the interdisciplinary sciences involving bioanalytical methods, chemical biology, drug discovery, medicinal chemistry, systems biology, and cancer biology.
Lab website: http://xuelab.org
Language
Position
Research Topics
Biochemistry, Biomedical Sciences, Biophysics, Cancer, Cell Biology, Drug Design and Discovery, Epigenetics, Imaging, Personalized Medicine, Pharmacology, Proteases, Trafficking
Multi-Disciplinary Training Areas
Cancer Biology [CAB], Disease Mechanisms and Therapeutics (DMT)
