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Ming-Hu Han, PhD
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About Me
Dr. Han is a Professor in the Department of Pharmacological Sciences, with a joint appointment in the Department of Neuroscience. The Han Laboratory studies neurophysiological mechanisms of depression and alcohol addiction in rodent models.
Search PubMed for articles
Language
Position
Research Topics
Addiction, Behavioral Health, Depression, Motor Neuron, Neural Networks, Neurophysiology, Stress, Synapses, Synaptic Plasticity, Synaptogenesis, Systems Neuroscience
Multi-Disciplinary Training Areas
Neuroscience [NEU], Pharmacology and Therapeutics Discovery [PTD]
About Me
Dr. Han is a Professor in the Department of Pharmacological Sciences, with a joint appointment in the Department of Neuroscience. The Han Laboratory studies neurophysiological mechanisms of depression and alcohol addiction in rodent models.
Search PubMed for articles
Language
Position
Research Topics
Addiction, Behavioral Health, Depression, Motor Neuron, Neural Networks, Neurophysiology, Stress, Synapses, Synaptic Plasticity, Synaptogenesis, Systems Neuroscience
Multi-Disciplinary Training Areas
Neuroscience [NEU], Pharmacology and Therapeutics Discovery [PTD]
About Me
Dr. Han is a Professor in the Department of Pharmacological Sciences, with a joint appointment in the Department of Neuroscience. The Han Laboratory studies neurophysiological mechanisms of depression and alcohol addiction in rodent models.
Search PubMed for articles
Language
Position
Research Topics
Addiction, Behavioral Health, Depression, Motor Neuron, Neural Networks, Neurophysiology, Stress, Synapses, Synaptic Plasticity, Synaptogenesis, Systems Neuroscience
Multi-Disciplinary Training Areas
Neuroscience [NEU], Pharmacology and Therapeutics Discovery [PTD]
Education
PhD, Shanghai Institute of Physiology, Chinese Academy of Sciences
Postdoctoral Fellowship, Yale University School of Medicine
Faculty Fellowship, University of Texas Southwestern Medical Center
Awards
2021
Faculty Council Senior Faculty Award for Academic Excellence
Icahn School Of Medicine At Mount Sinai
2020
Fellow of the ACNP
American College of Neuropsychopharmacology
2019
Fellow of the CINP
The International College of Neuropsychopharmacology
2016
NAMI-New York State Excellence in Research Award
National Alliance on Mental Illness (NAMI), New York State
2015
NARSAD Independent Investigator Award
Brain & Behavior Research Foundation
2013
Faculty Council Award for Academic Excellence
Icahn School of Medicine at Mount Sinai
2012
Dr. Harold & Golden Lamport Research Award for Excellence in Basic Science Research
Mount Sinai School of Medicine
2011
Rising Star Translational Research Award
Johnson & Johnson and International Mental Health Research Organization (IMHRO)
2011
Travel Award
American College of Neuropsychopharmacology (ACNP)
2007
Young Investigator Award
National Alliance for Research on Schizophrenia and Depression (NARSAD)
Research
To understand the roles of neuroadaptations in mediating behavioral changes, the laboratory employs an up-down-up methodology: established behavior model - neuroadaptation - molecular/ionic mechanism - molecular/ionic manipulation - validation of neuronal function - behavioral test. The laboratory uses in vivo and in vitro electrophysiological techniques to identify neuroadaptations and investigate molecular/ionic mechanisms, and employs advanced gene manipulation approaches, including viral-mediated gene delivery, local knockouts of interested genes, and optogenetic tools, to conduct molecular/ionic manipulation followed by behavioral assays. The combination of these gene manipulation techniques and neurophysiology offers the laboratory a unique ability to explore the neurophysiological basis of depression and alcoholism.
For more information, visit Ming-Hu Han’s Laboratory of Cellular Neurophysiology.
Affiliations
Conte Center on Epigenetic Mechanisms of Depression
Locations
Publications
Recent Artifacts
- Lateral septum-lateral hypothalamus circuit dysfunction in comorbid pain and anxiety
- Noradrenergic modulation of stress resilience
- Midbrain projection to the basolateral amygdala encodes anxiety-like but not depression-like behaviors
- The Role of Beta-Adrenergic Receptors in Depression and Resilience
- Selective activation of ABCA1/ApoA1 signaling in the V1 by magnetoelectric stimulation ameliorates depression via regulation of synaptic plasticity
- The Potential of KCNQ Potassium Channel Openers as Novel Antidepressants
- Impact of the KCNQ2/3 channel opener ezogabine on reward circuit activity and clinical symptoms in depression: Results from a randomized controlled trial
- A Novel Role for Hypothalamic AgRP Neurons in Mediating Depressive Behavior
- The Resilient Phenotype Induced by Prophylactic Ketamine Exposure During Adolescence Is Mediated by the Ventral Tegmental Area–Nucleus Accumbens Pathway
- Chronic Pain Impairs Memory Formation via Disruption of Neurogenesis Mediated by Mesohippocampal Brain-Derived Neurotrophic Factor Signaling
Industry Relationships
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.
Dr. Han is not currently required to report Industry relationships.
Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.